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It affects approximately half of all cancer patients and leads to a decrease in treatment efficacy, quality of life, and survival. The human microbiota has been implicated in the onset and propagation of cancer cachexia. Dysbiosis, or the imbalance of the microbial communities, may lead to chronic systemic inflammation and contribute to the clinical phenotype of cachexia. Though the relationship between the gut microbiome, inflammation, and cachexia has been previously studied, the oral microbiome remains largely unexplored. As the initial point of digestion, the oral microbiome plays an important role in regulating systemic health. Oral dysbiosis leads to the upregulation of pro-inflammatory cytokines and an imbalance in natural flora, which in turn may contribute to muscle wasting associated with cachexia. Reinstating this equilibrium with the use of prebiotics and probiotics has the potential to improve the quality of life for patients suffering from cancer-related cachexia.<\/jats:p>","DOI":"10.3390\/microorganisms10112291","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T03:57:44Z","timestamp":1668743864000},"page":"2291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From Mouth to Muscle: Exploring the Potential Relationship between the Oral Microbiome and Cancer-Related Cachexia"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-7276","authenticated-orcid":false,"given":"Shreya R.","family":"Raman","sequence":"first","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-0931","authenticated-orcid":false,"given":"Kelly M.","family":"Herremans","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-5400","authenticated-orcid":false,"given":"Andrea N.","family":"Riner","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-3771","authenticated-orcid":false,"given":"Vignesh","family":"Vudatha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9117-0130","authenticated-orcid":false,"given":"Devon C.","family":"Freudenberger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley L.","family":"McKinley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-4866","authenticated-orcid":false,"given":"Eric W.","family":"Triplett","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose G.","family":"Trevino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, Canada"},{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23284, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sender, R., Fuchs, S., and Milo, R. 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