{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:41:02Z","timestamp":1792683662637,"version":"4.5.0"},"reference-count":109,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Group B Streptococcus (GBS) or Streptococcus agalactiae is a major cause of neonatal mortality. When colonizing the lower genital tract of pregnant women, GBS may cause premature birth and stillbirth. If transmitted to the newborn, it may result in life-threatening illnesses, including sepsis, meningitis, and pneumonia. Moreover, through continuous evolution, GBS can use its original structure and unique factors to greatly improve its survival rate in the human body. This review discusses the key virulence factors that facilitate GBS invasion and colonization and their action mechanisms. A comprehensive understanding of the role of virulence factors in GBS infection is crucial to develop better treatment options and screen potential candidate molecules for the development of the vaccine.<\/jats:p>","DOI":"10.3390\/microorganisms10122483","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T04:54:14Z","timestamp":1671080054000},"page":"2483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Group B Streptococcus: Virulence Factors and Pathogenic Mechanism"],"prefix":"10.3390","volume":"10","author":[{"given":"Yuxin","family":"Liu","sequence":"first","affiliation":[{"name":"Queen Mary School, Nanchang University, Nanchang 330006, China"},{"name":"Biomedical Sciences School, Queen Mary University of London, London E1 4PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1093\/cid\/cix658","article-title":"Maternal Colonization with Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses","volume":"65","author":"Russell","year":"2017","journal-title":"Clin. 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