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Here, using a mouse model of C. muridarum respiratory infection, we were able to determine how Fc\u03b3RI regulates the host resistance against chlamydial invasion. According to our findings, the chlamydial loads and pulmonary pathology were both reduced in Fc\u03b3RI deficient (Fcgr1\u2212\/\u2212) animals. Being infected, monocytes, macrophages, neutrophils, DCs, CD4+\/CD8+ T cells, and effector Th1 subsets displayed increased Fc\u03b3RI expression patterns. Altered infiltration of these cells in the lungs of Fcgr1\u2212\/\u2212 mice further demonstrated the regulation of Fc\u03b3RI in the immune system and identified Th1 cells and macrophages as its target cell populations. As expected, we observed that the Th1 response was augmented in Fcgr1\u2212\/\u2212 mice, while the pro-inflammatory M1 macrophage polarization was constrained. These findings might indicate Fc\u03b3RI as a potential regulator for host immunity and inflammatory response during chlamydial infection.<\/jats:p>","DOI":"10.3390\/microorganisms11010039","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:02:15Z","timestamp":1671764535000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Pathogenic Role for Fc\u03b3RI in the Immune Response against Chlamydial Respiratory Infection"],"prefix":"10.3390","volume":"11","author":[{"given":"Jiajia","family":"Zeng","sequence":"first","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaini","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Tuo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongci","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchun","family":"Che","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingsha","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rother, M., Teixeira da Costa, A.R., Zietlow, R., Meyer, T.F., and Rudel, T. (2019). Modulation of Host Cell Metabolism by Chlamydia trachomatis. Microbiol. Spectr., 7.","DOI":"10.1128\/microbiolspec.BAI-0012-2019"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro.2016.30","article-title":"Chlamydia cell biology and pathogenesis","volume":"14","author":"Elwell","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","first-page":"9","article-title":"Immune-mediated control of Chlamydia infection","volume":"10","author":"Roan","year":"2008","journal-title":"Cell Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"639834","DOI":"10.3389\/fimmu.2021.639834","article-title":"Insights Into Host Cell Cytokines in Chlamydia Infection","volume":"12","author":"Xiang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/femsre\/fuw027","article-title":"Sensing the enemy, containing the threat: Cell-autonomous immunity to Chlamydia trachomatis","volume":"40","author":"Finethy","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.158.7.3344","article-title":"Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways","volume":"158","author":"Perry","year":"1997","journal-title":"J. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.immuni.2017.07.009","article-title":"Fcgamma Receptor Function and the Design of Vaccination Strategies","volume":"47","author":"Bournazos","year":"2017","journal-title":"Immunity"},{"key":"ref_8","first-page":"105","article-title":"FcgammaRs in health and disease","volume":"350","author":"Nimmerjahn","year":"2011","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.12350","article-title":"Mouse and human FcR effector functions","volume":"268","author":"Bruhns","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4322092","DOI":"10.1155\/2022\/4322092","article-title":"IL-21\/IL-21R Regulates the Neutrophil-Mediated Pathologic Immune Response during Chlamydial Respiratory Infection","volume":"2022","author":"Zeng","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3389\/fimmu.2019.01958","article-title":"Expression, Role, and Regulation of Neutrophil Fcgamma Receptors","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1074-7613(02)00287-X","article-title":"FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses","volume":"16","author":"Barnes","year":"2002","journal-title":"Immunity"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1074-7613(02)00294-7","article-title":"FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection","volume":"16","author":"Hellwig","year":"2002","journal-title":"Immunity"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.dci.2018.09.019","article-title":"The alternatively spliced porcine FcgammaRI regulated PRRSV-ADE infection and proinflammatory cytokine production","volume":"90","author":"Shi","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/cmi.2016.68","article-title":"CD103+ lung dendritic cells (LDCs) induce stronger Th1\/Th17 immunity to a bacterial lung infection than CD11b(hi) LDCs","volume":"15","author":"Shekhar","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.4049\/jimmunol.2000957","article-title":"IL-27\/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation","volume":"206","author":"Zha","year":"2021","journal-title":"J. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.0901584","article-title":"IL-17\/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function","volume":"183","author":"Bai","year":"2009","journal-title":"J. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0952-7915(02)00361-8","article-title":"The role of IFN-gamma in the outcome of chlamydial infection","volume":"14","author":"Rottenberg","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, Mechanisms, and Significance of Macrophage Plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Mohammadian","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: In vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.0019-2805.2001.01354.x","article-title":"Fc receptor regulation of protective immunity against Chlamydia trachomatis","volume":"105","author":"Moore","year":"2002","journal-title":"Immunology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.coi.2017.01.003","article-title":"Targeting NK-cell checkpoints for cancer immunotherapy","volume":"45","author":"Muntasell","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13045-021-01216-w","article-title":"Bispecific antibody-activated T cells enhance NK cell-mediated antibody-dependent cellular cytotoxicity","volume":"14","author":"Wang","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.smim.2014.02.003","article-title":"NK cell development and function--plasticity and redundancy unleashed","volume":"26","author":"Cichocki","year":"2014","journal-title":"Semin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.3389\/fimmu.2019.01414","article-title":"What Defines NK Cell Functional Fate: Phenotype or Metabolism?","volume":"10","author":"Poznanski","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1002\/eji.201445390","article-title":"NK cells modulate the lung dendritic cell-mediated Th1\/Th17 immunity during intracellular bacterial infection","volume":"45","author":"Shekhar","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4049\/jimmunol.1002519","article-title":"NK cells promote type 1 T cell immunity through modulating the function of dendritic cells during intracellular bacterial infection","volume":"187","author":"Jiao","year":"2011","journal-title":"J. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"775663","DOI":"10.3389\/fcimb.2021.775663","article-title":"Natural Killer Cells Regulate Pulmonary Macrophages Polarization in Host Defense Against Chlamydial Respiratory Infection","volume":"11","author":"Zhao","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"Krausgruber","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7150\/ijbs.8879","article-title":"Macrophage polarization in inflammatory diseases","volume":"10","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.smim.2015.02.001","article-title":"A transcriptional perspective on human macrophage biology","volume":"27","author":"Schultze","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"a030338","DOI":"10.1101\/cshperspect.a030338","article-title":"T Helper Cell Differentiation, Heterogeneity, and Plasticity","volume":"10","author":"Zhu","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1146\/annurev-immunol-103019-085803","article-title":"In Vivo CD4(+) T Cell Differentiation and Function: Revisiting the Th1\/Th2 Paradigm","volume":"38","author":"Ruterbusch","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","article-title":"Plasticity of CD4+ T cell lineage differentiation","volume":"30","author":"Zhou","year":"2009","journal-title":"Immunity"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/11\/1\/39\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:48:23Z","timestamp":1760147303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/11\/1\/39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,22]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["microorganisms11010039"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms11010039","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,22]]}}}