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Rodents are the most important reservoirs for both human and animal infection. An epidemiological survey of pathogenic Leptospira in rodents is important for the prevention and control of leptospirosis. In this study, a total of 964 rodents were captured from six cities in Hubei Province, and two pathogenic Leptospira species (L.\u00a0interrogans and L.\u00a0borgpetersenii) were detected using nested PCR with an overall prevalence of 4.8%. L.\u00a0interrogans was distributed in five sampling sites, which may be the dominant species of pathogenic Leptospira in Hubei Province. In addition, Rattus norvegicus showed a relatively high infection rate, which may play an important role in the transmission and infection of pathogenic Leptospira. This study reveals the prevalence of pathogenic Leptospira in wild rodents in Hubei Province, suggesting that the risk of leptospirosis infection in Hubei Province still exists.<\/jats:p>","DOI":"10.3390\/microorganisms11010099","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:56:27Z","timestamp":1672635387000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pathogenic Leptospira Infections in Hubei Province, Central China"],"prefix":"10.3390","volume":"11","author":[{"given":"Jiale","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaorui","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxin","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control & Prevention, 6 Zuodaoquan Road, Wuhan 430079, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Virology, Wuhan Center for Disease Control & Prevention, 288 Machang Road, Wuhan 430015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-133X","authenticated-orcid":false,"given":"Kun","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control & Prevention, 6 Zuodaoquan Road, Wuhan 430079, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjun","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-455X","authenticated-orcid":false,"given":"Wei","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology\/Department of Laboratory Medicine\/Hubei Provincial Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Zhongnan Hospital, Wuhan University, 185 Donghu Road, Wuhan 430071, China"},{"name":"School of Public Health, Wuhan University, 185 Donghu Road, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20020","DOI":"10.1038\/srep20020","article-title":"Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. 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