{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:40:15Z","timestamp":1778542815779,"version":"3.51.4"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Cancerologia, ESE, nation investment resources","award":["C19010300-416"],"award-info":[{"award-number":["C19010300-416"]}]},{"name":"Instituto Nacional de Cancerologia, ESE, nation investment resources","award":["2018-2021"],"award-info":[{"award-number":["2018-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Patients with cancer have a higher risk of severe bacterial infections. This study aims to determine the frequency, susceptibility profiles, and resistance genes of bacterial species involved in bacteremia, as well as risk factors associated with mortality in cancer patients in Colombia. In this prospective multicenter cohort study of adult patients with cancer and bacteremia, susceptibility testing was performed and selected resistance genes were identified. A multivariate regression analysis was carried out for the identification of risk factors for mortality. In 195 patients, 206 microorganisms were isolated. Gram-negative bacteria were more frequently found, in 142 cases (68.9%): 67 Escherichia coli (32.5%), 36 Klebsiella pneumoniae (17.4%), and 21 Pseudomonas aeruginosa (10.1%), and 18 other Gram-negative isolates (8.7%). Staphylococcus aureus represented 12.4% (n = 25). Among the isolates, resistance to at least one antibiotic was identified in 63% of them. Genes coding for extended-spectrum beta-lactamases and carbapenemases, blaCTX-M and blaKPC, respectively, were commonly found. Mortality rate was 25.6% and it was lower in those with adequate empirical antibiotic treatment (22.0% vs. 45.2%, OR: 0.26, 95% CI: 0.1\u20130.63, in the multivariate model). In Colombia, in patients with cancer and bacteremia, bacteria have a high resistance profile to beta-lactams, with a high incidence of extended-spectrum beta-lactamases and carbapenemases. Adequate empirical treatment diminishes mortality, and empirical selection of treatment in this environment of high resistance is of key importance.<\/jats:p>","DOI":"10.3390\/microorganisms11020359","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:52:02Z","timestamp":1675219922000},"page":"359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Molecular and Clinical Data of Antimicrobial Resistance in Microorganisms Producing Bacteremia in a Multicentric Cohort of Patients with Cancer in a Latin American Country"],"prefix":"10.3390","volume":"11","author":[{"given":"Sergio Andr\u00e9s","family":"Cruz-Vargas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogot\u00e1, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Garc\u00eda-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogot\u00e1, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-880X","authenticated-orcid":false,"given":"Sonia Isabel","family":"Cuervo-Maldonado","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogot\u00e1, Bogot\u00e1 111321, Colombia"},{"name":"Infectious Diseases Group, Instituto Nacional de Cancerolog\u00eda-ESE, Bogot\u00e1 111511, Colombia"},{"name":"Research Group in Cancer Infectious Diseases and Hematological Alterations (GREICAH), Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-4494","authenticated-orcid":false,"given":"Carlos Arturo","family":"\u00c1lvarez-Moreno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogot\u00e1, Bogot\u00e1 111321, Colombia"},{"name":"Cl\u00ednica Universitaria Colombia, Bogota 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Humberto","family":"Saavedra-Trujillo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogot\u00e1, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-2461","authenticated-orcid":false,"given":"Jos\u00e9 Camilo","family":"\u00c1lvarez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Group, Instituto Nacional de Cancerolog\u00eda-ESE, Bogot\u00e1 111511, Colombia"},{"name":"Research Group in Cancer Infectious Diseases and Hematological Alterations (GREICAH), Bogot\u00e1 111321, Colombia"},{"name":"Hospital Universitario Cl\u00ednica San Rafael, Bogot\u00e1 110111, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-6847","authenticated-orcid":false,"given":"Ang\u00e9lica","family":"Arango-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Group, Instituto Nacional de Cancerolog\u00eda-ESE, Bogot\u00e1 111511, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-1409","authenticated-orcid":false,"given":"Julio C\u00e9sar","family":"G\u00f3mez-Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Infectious Diseases Group, Instituto Nacional de Cancerolog\u00eda-ESE, Bogot\u00e1 111511, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Garc\u00eda-Guzman","sequence":"additional","affiliation":[{"name":"Infectious Diseases Group, Instituto Nacional de Cancerolog\u00eda-ESE, Bogot\u00e1 111511, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aura Luc\u00eda","family":"Leal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Garz\u00f3n-Herazo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario San Ignacio, Bogot\u00e1 110231, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Mart\u00ednez-Vernaza","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario San Ignacio, Bogot\u00e1 110231, Colombia"},{"name":"Research Group in Infectious Diseases, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredy Orlando","family":"Guevara","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Cl\u00ednica Reina Sof\u00eda, Bogot\u00e1 110121, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leydy Paola","family":"Jim\u00e9nez-Cetina","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Instituto Nacional de Cancerolog\u00eda-ESE, Bogot\u00e1 111511, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana Marcela","family":"Mora","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Instituto Nacional de Cancerolog\u00eda-ESE, Bogot\u00e1 111511, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Yamile","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-9652","authenticated-orcid":false,"given":"Jorge Alberto","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogot\u00e1, Bogot\u00e1 111321, Colombia"},{"name":"Diseases Unit, Hospital Universitario Nacional, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/cid\/ciq147","article-title":"Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of 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