{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:51:52Z","timestamp":1760147512552,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Changsha","award":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"],"award-info":[{"award-number":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"]}]},{"name":"Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project","award":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"],"award-info":[{"award-number":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"]}]},{"name":"National Natural Science Foundation of China","award":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"],"award-info":[{"award-number":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"]}]},{"name":"Scientific Research Fund of Hunan Provincial Education Department","award":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"],"award-info":[{"award-number":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"]}]},{"name":"Construction of Innovative Provinces in Hunan Province","award":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"],"award-info":[{"award-number":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"]}]},{"name":"Shanghai OE Biotech Co., Ltd.","award":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"],"award-info":[{"award-number":["kq2208167","TSBICIP-CXRC-038","32130099","31700004","31900485","21A0060","2019RS3022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The abuse of antibiotics has become a serious health challenge in the veterinary field. It creates environmental selection pressure on bacteria and facilitates the rapid spread of antibiotic resistance genes. The speed of discovery and application of cost-effective alternatives to antibiotics is slow in pig production. Natural products from biosynthetic gene clusters (BGCs) represent promising therapeutic agents for animal and human health and have attracted extraordinary passion from researchers due to their ability to participate in biofilm inhibition, stress resistance, and the killing of competitors. In this study, we detected the presence of diverse secondary metabolite genes in porcine intestines through sequence alignment in the antiSMASH database. After comparing variations in microbial BGCs\u2019 composition between the ileum and the colon, it was found that the abundance of the resorcinol gene cluster was elevated in the ileal microbiome, whereas the gene cluster of arylpolyene was enriched in the colonic microbiome. The investigation of BGCs\u2019 diversity and composition differences between the ileal and colonic microbiomes provided novel insights into further utilizing BGCs in livestock. The importance of BGCs in gut microbiota deserves more attention for promoting healthy swine production.<\/jats:p>","DOI":"10.3390\/microorganisms11020434","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T02:32:07Z","timestamp":1675909927000},"page":"434","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biosynthetic Gene Clusters from Swine Gut Microbiome"],"prefix":"10.3390","volume":"11","author":[{"given":"Leli","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China"},{"name":"Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410081, China"},{"name":"Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Center of Technology Innovation for Synthetic Biology, Tianjin 300308, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuni","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanmei","family":"Yin","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-9485","authenticated-orcid":false,"given":"Qiang","family":"Tu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huansheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-3490","authenticated-orcid":false,"given":"Jia","family":"Yin","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aao1495","article-title":"Reducing antimicrobial use in food animals","volume":"357","author":"Glennon","year":"2017","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/imr.12563","article-title":"The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens","volume":"279","author":"Kim","year":"2017","journal-title":"Immunol. 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