{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:02:28Z","timestamp":1769608948621,"version":"3.49.0"},"reference-count":97,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The common cold, which is mostly caused by respiratory viruses and clinically represented by the symptoms of acute respiratory viral infections (ARVI) with mainly upper respiratory tract involvement, is an important problem in pediatric practice. Due to the high prevalence, socio-economic burden, and lack of effective prevention measures (except for influenza and, partially, RSV infection), ARVI require strong medical attention. The purpose of this descriptive literature review was to analyze the current practical approaches to the treatment of ARVI to facilitate the choice of therapy in routine practice. This descriptive overview includes information on the causative agents of ARVI. Special attention is paid to the role of interferon gamma as a cytokine with antiviral and immunomodulatory effects on the pathogenesis of ARVI. Modern approaches to the treatment of ARVI, including antiviral, pathogenesis-directed and symptomatic therapy are presented. The emphasis is on the use of antibody-based drugs in the immunoprophylaxis and immunotherapy of ARVI. The data presented in this review allow us to conclude that a modern, balanced and evidence-based approach to the choice of ARVI treatment in children should be used in clinical practice. The published results of clinical trials and systematic reviews with meta-analyses of ARVI in children allow us to conclude that it is possible and expedient to use broad-spectrum antiviral drugs in complex therapy. This approach can provide an adequate response of the child\u2019s immune system to the virus without limiting the clinical possibilities of using only symptomatic therapy.<\/jats:p>","DOI":"10.3390\/microorganisms11040858","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T02:58:21Z","timestamp":1679972301000},"page":"858","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Common Cold and Influenza in Children: To Treat or Not to Treat?"],"prefix":"10.3390","volume":"11","author":[{"given":"Natalia A.","family":"Geppe","sequence":"first","affiliation":[{"name":"Filatov Clinical Institute of Children\u2019s Health, Sechenov First Moscow State Medical University, Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey L.","family":"Zaplatnikov","sequence":"additional","affiliation":[{"name":"Russian Medical Academy of Continuous Professional Education, Moscow 123242, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena G.","family":"Kondyurina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Advanced Training and Professional Retraining, Novosibirsk State Medical University, Novosibirsk 630091, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Chepurnaya","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Rostov Regional Children\u2019s Clinical Hospital, Rostov 344015, Russia"},{"name":"Department of Pediatrics, Rostov State Medical University, Rostov 344022, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia G.","family":"Kolosova","sequence":"additional","affiliation":[{"name":"Filatov Clinical Institute of Children\u2019s Health, Sechenov First Moscow State Medical University, Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s13337-022-00761-3","article-title":"Respiratory viral infections other than SARS-CoV-2 among the North Indian patients presenting with acute respiratory illness during the first COVID-19 wave","volume":"33","author":"Sapra","year":"2022","journal-title":"Virusdisease"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kiseleva, I., and Ksenafontov, A. 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