{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:21:21Z","timestamp":1784164881983,"version":"3.55.0"},"reference-count":44,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Algerian Ministry of Higher Education and Scientific Research","award":["DOOL01UN270120230003"],"award-info":[{"award-number":["DOOL01UN270120230003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>This study aims to see if probiotic bacteria from human milk could ameliorate oral cow\u2019s milk sensitization. The probiotic potential of the SL42 strain isolated from the milk of a healthy young mother was first determined. Rats were then randomly gavaged with cow\u2019s milk casein without an adjuvant or assigned to the control group. Each group was further subdivided into three groups, with each receiving only Limosilactobacillus reuteri DSM 17938, SL42, or a phosphate-buffered saline solution. Body weight, temperature, eosinophils, serum milk casein-specific IgE (CAS-IgE), histamine, and serum S100A8\/A9 and inflammatory cytokine concentrations were measured. The animals were sacrificed after 59 days; histological sections were prepared, and the spleen or thymus weights, as well as the diversity of the gut microbiota, were measured. On days 1 and 59, SL42 abridged systemic allergic responses to casein by dropping histamine levels (25.7%), CAS-specific IgE levels (53.6%), eosinophil numbers (17%), S100A8\/9 (18.7%), and cytokine concentrations (25.4\u201348.5%). Analyses of histological sections of the jejunum confirmed the protective effect of probiotic bacteria in the CAS-challenged groups. Lactic acid bacteria and Clostridia species were also increased in all probiotic-treated groups. These findings suggest that probiotics derived from human milk could be used to alleviate cow\u2019s milk casein allergy.<\/jats:p>","DOI":"10.3390\/microorganisms11041030","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T09:23:43Z","timestamp":1681464223000},"page":"1030","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Probiotic Bacteria from Human Milk Can Alleviate Oral Bovine Casein Sensitization in Juvenile Wistar Rats"],"prefix":"10.3390","volume":"11","author":[{"given":"Kawtar","family":"Keddar","sequence":"first","affiliation":[{"name":"Laboratoire des Micro-Organismes B\u00e9n\u00e9fiques, des Aliments Fonctionnels et de la Sant\u00e9 (LMBAFS), Abdelhamid Ibn Badis University, Hocine Hamadou Street, Mostaganem 27000, Algeria"},{"name":"Laboratoire de Bio-Economie, S\u00e9curit\u00e9 Alimentaire et Sant\u00e9, Abdelhamid Ibn Badis University, Hocine Hamadou Street, Mostaganem 27000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnia","family":"Ziar","sequence":"additional","affiliation":[{"name":"Laboratoire des Micro-Organismes B\u00e9n\u00e9fiques, des Aliments Fonctionnels et de la Sant\u00e9 (LMBAFS), Abdelhamid Ibn Badis University, Hocine Hamadou Street, Mostaganem 27000, Algeria"},{"name":"Micalis Institute, INRAE, AgroParisTech, Paris-Saclay University, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noussaiba","family":"Belmadani","sequence":"additional","affiliation":[{"name":"Laboratoire des Micro-Organismes B\u00e9n\u00e9fiques, des Aliments Fonctionnels et de la Sant\u00e9 (LMBAFS), Abdelhamid Ibn Badis University, Hocine Hamadou Street, Mostaganem 27000, Algeria"},{"name":"Laboratoire de Bio-Economie, S\u00e9curit\u00e9 Alimentaire et Sant\u00e9, Abdelhamid Ibn Badis University, Hocine Hamadou Street, Mostaganem 27000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Monnoye","sequence":"additional","affiliation":[{"name":"Micalis Institute, INRAE, AgroParisTech, Paris-Saclay University, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9521-0067","authenticated-orcid":false,"given":"Philippe","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Micalis Institute, INRAE, AgroParisTech, Paris-Saclay University, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Riazi","sequence":"additional","affiliation":[{"name":"Laboratoire des Micro-Organismes B\u00e9n\u00e9fiques, des Aliments Fonctionnels et de la Sant\u00e9 (LMBAFS), Abdelhamid Ibn Badis University, Hocine Hamadou Street, Mostaganem 27000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s11882-017-0703-4","article-title":"Food Allergy in South Africa","volume":"17","author":"Gray","year":"2017","journal-title":"Curr. 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