{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:07:24Z","timestamp":1790806044935,"version":"4.1.0"},"reference-count":139,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minist\u00e8re de l\u2019Education Nationale de la Recherche et de la Technologie","award":["ULR3610"],"award-info":[{"award-number":["ULR3610"]}]},{"name":"Minist\u00e8re de l\u2019Education Nationale de la Recherche et de la Technologie","award":["130771P"],"award-info":[{"award-number":["130771P"]}]},{"name":"\u201cSSHN JEUNE CHERCHEUR\u201d scholarship of Minist\u00e8re de l\u2019Europe et des Affaires Etrang\u00e8res and by Campus France","award":["ULR3610"],"award-info":[{"award-number":["ULR3610"]}]},{"name":"\u201cSSHN JEUNE CHERCHEUR\u201d scholarship of Minist\u00e8re de l\u2019Europe et des Affaires Etrang\u00e8res and by Campus France","award":["130771P"],"award-info":[{"award-number":["130771P"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Poliovirus (PV), the virus that causes both acute poliomyelitis and post-polio syndrome, is classified within the Enterovirus C species, and there are three wild PV serotypes: WPV1, WPV2 and WPV3. The launch of the Global Polio Eradication Initiative (GPEI) in 1988 eradicated two of the three serotypes of WPV (WPV2 and WPV3). However, the endemic transmission of WPV1 persists in Afghanistan and Pakistan in 2022. There are cases of paralytic polio due to the loss of viral attenuation in the oral poliovirus vaccine (OPV), known as vaccine-derived poliovirus (VDPV). Between January 2021 and May 2023, a total of 2141 circulating VDPV (cVDPV) cases were reported in 36 countries worldwide. Because of this risk, inactivated poliovirus (IPV) is being used more widely, and attenuated PV2 has been removed from OPV formulations to obtain bivalent OPV (containing only types 1 and 3). In order to avoid the reversion of attenuated OPV strains, the new OPV, which is more stable due to genome-wide modifications, as well as sabin IPV and virus-like particle (VLP) vaccines, is being developed and offers promising solutions for eradicating WP1 and VDPV.<\/jats:p>","DOI":"10.3390\/microorganisms11051323","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:00:29Z","timestamp":1684389629000},"page":"1323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Fight against Poliovirus Is Not Over"],"prefix":"10.3390","volume":"11","author":[{"given":"Chaldam Jesp\u00e8re","family":"Mbani","sequence":"first","affiliation":[{"name":"Laboratoire de Virologie URL3610, Universit\u00e9 de Lille, CHU Lille, 59000 Lille, France"},{"name":"Laboratoire de Biologie Cellulaire et Mol\u00e9culaire, Facult\u00e9 des Sciences et Technique, Universit\u00e9 Marien Ngouabi, Brazzaville BP 69, Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2981-0803","authenticated-orcid":false,"given":"Magloire Pandoua","family":"Nekoua","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie URL3610, Universit\u00e9 de Lille, CHU Lille, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatien","family":"Moukassa","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Cellulaire et Mol\u00e9culaire, Facult\u00e9 des Sciences et Technique, Universit\u00e9 Marien Ngouabi, Brazzaville BP 69, Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-2074","authenticated-orcid":false,"given":"Didier","family":"Hober","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie URL3610, Universit\u00e9 de Lille, CHU Lille, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1128\/JVI.77.16.8973-8984.2003","article-title":"Complete genomic sequencing shows that polioviruses and members of human enterovirus species C are closely related in the noncapsid coding region","volume":"77","author":"Brown","year":"2003","journal-title":"J. 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