{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:15:25Z","timestamp":1789694125652,"version":"4.0.1"},"reference-count":78,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The overprescribing and misuse of antibiotics have led to the rapid development of multidrug-resistant bacteria, such as those that cause UTIs. UTIs are the most common outpatient infections and are mainly caused by Escherichia coli and Klebsiella spp., although some Gram-positive bacteria, such as Pseudomonas aeruginosa, have been isolated in many cases. The rise of antimicrobial-resistant bacteria is a major public health concern, as it is predicted to lead to increased healthcare costs and poor patient outcomes and is expected to be the leading cause of global mortality by 2050. Antibiotic resistance among bacterial species can arise from a myriad of factors, including intrinsic and acquired resistance mechanisms, as well as mobile genetic elements, such as transposons, integrons, and plasmids. Plasmid-mediated resistance is of major concern as drug-resistance genes can quickly and efficiently spread across bacterial species via horizontal gene transfer. The emergence of extended-spectrum \u03b2-lactamases (ESBLs) such as NDM-1, OXA, KPC, and CTX-M family members has conferred resistance to many commonly used antibiotics in the treatment of UTIs, including penicillins, carbapenems, cephalosporins, and sulfamethoxazole. This review will focus on plasmid-mediated bacterial genes, especially those that encode ESBLs, and how they contribute to antibiotic resistance. Early clinical detection of these genes in patient samples will provide better treatment options and reduce the threat of antibiotic resistance.<\/jats:p>","DOI":"10.3390\/microorganisms11061407","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:10:53Z","timestamp":1685203853000},"page":"1407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Genetic Factors That Contribute to Antibiotic Resistance through Intrinsic and Acquired Bacterial Genes in Urinary Tract Infections"],"prefix":"10.3390","volume":"11","author":[{"given":"Mohammed","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Healthcare Genetics and Genomics, Clemson University, Clemson, SC 29634, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Fasolino","sequence":"additional","affiliation":[{"name":"Department of Healthcare Genetics and Genomics, Clemson University, Clemson, SC 29634, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ivankovic","sequence":"additional","affiliation":[{"name":"Department of Healthcare Genetics and Genomics, Clemson University, Clemson, SC 29634, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Healthcare Genetics and Genomics, Clemson University, Clemson, SC 29634, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Brownlee","sequence":"additional","affiliation":[{"name":"Department of Healthcare Genetics and Genomics, Clemson University, Clemson, SC 29634, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.2147\/IDR.S234610","article-title":"Antimicrobial Resistance: Implications and Costs","volume":"12","author":"Dadgostar","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: Epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Walker","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","article-title":"International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases","volume":"52","author":"Gupta","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrmicro1445","article-title":"Non-inherited antibiotic resistance","volume":"4","author":"Levin","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2217\/fmb.12.63","article-title":"Acquired inducible antimicrobial resistance in Gram-positive bacteria","volume":"7","author":"Chancey","year":"2012","journal-title":"Future Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3934\/microbiol.2018.3.482","article-title":"An overview of the antimicrobial resistance mechanisms of bacteria","volume":"4","author":"Reygaert","year":"2018","journal-title":"AIMS Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/mdr.1996.2.273","article-title":"Diffusion of carbapenems through the outer membrane of enterobacteriaceae and correlation of their activities with their periplasmic concentrations","volume":"2","author":"Cornaglia","year":"1996","journal-title":"Microb. Drug Resist."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/jac\/28.4.499","article-title":"Imipenem resistance associated with the loss of a 40 kDa outer membrane protein in Enterobacter aerogenes","volume":"28","author":"Chow","year":"1991","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1365-2958.1989.tb00153.x","article-title":"A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: Integrons","volume":"3","author":"Stokes","year":"1989","journal-title":"Mol. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.tim.2018.06.007","article-title":"Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context","volume":"26","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","article-title":"Global increase and geographic convergence in antibiotic consumption between 2000 and 2015","volume":"115","author":"Klein","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00013542-200410000-00003","article-title":"Class C \u03b2-Lactamases: An increasing problem worldwide","volume":"15","author":"Beceiro","year":"2004","journal-title":"Rev. Med. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/CMR.00036-08","article-title":"AmpC beta-lactamases","volume":"22","author":"Jacoby","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/cid\/ciz173","article-title":"A Primer on AmpC beta-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World","volume":"69","author":"Tamma","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1128\/JCM.40.6.2153-2162.2002","article-title":"Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR","volume":"40","author":"Hanson","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13756-019-0494-6","article-title":"Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt","volume":"8","author":"Rensing","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1469-0691.2012.03850.x","article-title":"Extended-spectrum beta-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: A global perspective","volume":"18","author":"Ewers","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"i57","DOI":"10.1093\/jac\/dkt027","article-title":"Molecular epidemiology of extended-spectrum beta-lactamase-, AmpC beta-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11","volume":"68","author":"Denisuik","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1128\/AAC.45.10.2716-2722.2001","article-title":"Evidence for transfer of CMY-2 AmpC beta-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans","volume":"45","author":"Winokur","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1128\/AAC.48.4.1353-1356.2004","article-title":"Dissemination of blaCMY-2 among Escherichia coli isolates from food animals, retail ground meats, and humans in southern Taiwan","volume":"48","author":"Yan","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1128\/AEM.06498-11","article-title":"Characterization of blaCMY-2 plasmids in Salmonella and Escherichia coli isolates from food animals in Canada","volume":"78","author":"Martin","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2147\/IDR.S159345","article-title":"ISEcp1-mediated transposition of chromosome-borne blaCMY-2 into an endogenous ColE1-like plasmid in Escherichia coli","volume":"11","author":"Fang","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1128\/AAC.38.9.2150","article-title":"Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants","volume":"38","author":"Ayala","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.ijantimicag.2019.09.017","article-title":"The mobile FOX AmpC beta-lactamases originated in Aeromonas allosaccharophila","volume":"54","author":"Ebmeyer","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1086\/512370","article-title":"Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn, New York","volume":"44","author":"Bratu","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1086\/648077","article-title":"Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient","volume":"49","author":"Sidjabat","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/JCM.00651-08","article-title":"Ertapenem resistance among extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates","volume":"47","author":"Leavitt","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e00088-17","DOI":"10.1128\/CMR.00088-17","article-title":"Mobile Genetic Elements Associated with Antimicrobial Resistance","volume":"31","author":"Partridge","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1469-0691.2012.03821.x","article-title":"Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe","volume":"18","author":"Canton","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/CMR.00001-07","article-title":"Carbapenemases: The versatile beta-lactamases","volume":"20","author":"Queenan","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/AAC.35.1.147","article-title":"Transferable imipenem resistance in Pseudomonas aeruginosa","volume":"35","author":"Watanabe","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(05)75604-X","article-title":"Carbapenem-hydrolysing IMP-1 beta-lactamase in Klebsiella pneumoniae from Singapore","volume":"353","author":"Koh","year":"1999","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1128\/JCM.43.1.516-519.2005","article-title":"First isolation of metallo-beta-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil","volume":"43","author":"Lincopan","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1469-0691.2006.01480.x","article-title":"First IMP-1-producing Klebsiella pneumoniae isolate in Turkey","volume":"12","author":"Aktas","year":"2006","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1128\/JCM.00197-07","article-title":"Successive emergence of extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter aerogenes isolates in a university hospital","volume":"46","author":"Biendo","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1631\/jzus.B0820302","article-title":"Detection of plasmid-mediated IMP-1 metallo-beta-lactamase and quinolone resistance determinants in an ertapenem-resistant Enterobacter cloacae isolate","volume":"10","author":"Chen","year":"2009","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1128\/AAC.43.7.1584","article-title":"Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate","volume":"43","author":"Lauretti","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e02109-17","DOI":"10.1128\/mBio.02109-17","article-title":"Ceftazidime Is the Key Diversification and Selection Driver of VIM-Type Carbapenemases","volume":"9","author":"Baquero","year":"2018","journal-title":"mBio"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1556\/030.65.2018.038","article-title":"Prevalence of VIM- and GIM-producing Acinetobacter baumannii from patients with severe urinary tract infection","volume":"65","author":"Girija","year":"2018","journal-title":"Acta Microbiol. Immunol. Hung."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1128\/AAC.49.8.3538-3540.2005","article-title":"First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States","volume":"49","author":"Lolans","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"611","DOI":"10.15585\/mmwr.mm6721a6","article-title":"Notes from the Field: Verona Integron-Encoded Metallo-Beta-Lactamase\u2013Producing Pseudomonas aeruginosa Outbreak in a Long-Term Acute Care Hospital\u2014Orange County, Florida, 2017","volume":"2018","author":"Rankin","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1128\/AAC.00774-09","article-title":"Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India","volume":"53","author":"Yong","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/CMR.00117-13","article-title":"OXA beta-lactamases","volume":"27","author":"Evans","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1089\/mdr.2015.0275","article-title":"Emergence of Oxacillinases in Environmental Carbapenem-Resistant Acinetobacter baumannii Associated with Clinical Isolates","volume":"22","author":"Hrenovic","year":"2016","journal-title":"Microb. Drug Resist."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1046\/j.1469-0691.2000.00107.x","article-title":"Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs)","volume":"6","author":"Paterson","year":"2000","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1128\/AAC.49.1.71-76.2005","article-title":"Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe","volume":"49","author":"Mammeri","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1128\/AAC.48.4.1295-1299.2004","article-title":"Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States","volume":"48","author":"Wang","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.mib.2006.08.011","article-title":"The CTX-M beta-lactamase pandemic","volume":"9","author":"Canton","year":"2006","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Baquero, F., Nombela, C., Cassell, G.H., and Guti\u00e9rrez-Fuentes, J.A. (2008). Evolutionary Biology of Bacterial and Fungal Pathogens, ASM Press.","DOI":"10.1128\/9781555815639"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3349\/ymj.1998.39.6.526","article-title":"Acquisition of methicillin resistance and progression of multiantibiotic resistance in methicillin-resistant Staphylococcus aureus","volume":"39","author":"Ito","year":"1998","journal-title":"Yonsei Med. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/jb.158.2.513-516.1984","article-title":"Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus","volume":"158","author":"Hartman","year":"1984","journal-title":"J. Bacteriol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.3389\/fmicb.2018.02723","article-title":"Factors Contributing to the Evolution of mecA-Mediated beta-lactam Resistance in Staphylococci: Update and New Insights From Whole Genome Sequencing (WGS)","volume":"9","author":"Miragaia","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/antibiotics3040572","article-title":"Old and New Glycopeptide Antibiotics: Action and Resistance","volume":"3","author":"Binda","year":"2014","journal-title":"Antibiotics"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/CMR.13.4.686","article-title":"Vancomycin-resistant enterococci","volume":"13","author":"Cetinkaya","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/jac\/dks166","article-title":"Diversity of vanA-type vancomycin-resistant Enterococcus faecium isolated from broilers, poultry slaughterers and hospitalized humans in Greece","volume":"67","author":"Tzavaras","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1056\/NEJM200003093421007","article-title":"Vancomycin-resistant enterococcal infections","volume":"342","author":"Murray","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41429-018-0113-4","article-title":"Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum beta-lactamase and vanA genes","volume":"72","author":"Kudo","year":"2019","journal-title":"J. Antibiot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1469-0691.2010.03182.x","article-title":"Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period","volume":"16","author":"Linares","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/jac\/43.5.637","article-title":"Distribution of mefE and ermB genes in macrolide-resistant strains of Streptococcus pneumoniae and their variable susceptibility to various antibiotics","volume":"43","author":"Nishijima","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/jcph.715","article-title":"Safety Concerns Surrounding Quinolone Use in Children","volume":"56","author":"Patel","year":"2016","journal-title":"J. Clin. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1001\/jama.2014.12842","article-title":"Diagnosis and management of urinary tract infections in the outpatient setting: A review","volume":"312","author":"Grigoryan","year":"2014","journal-title":"JAMA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/bi5000564","article-title":"Mechanism of quinolone action and resistance","volume":"53","author":"Aldred","year":"2014","journal-title":"Biochemistry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1086\/314056","article-title":"Mechanisms of action and resistance of older and newer fluoroquinolones","volume":"31","author":"Hooper","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1128\/AAC.01615-12","article-title":"Differential distribution of plasmid-mediated quinolone resistance genes in clinical enterobacteria with unusual phenotypes of quinolone susceptibility from Argentina","volume":"57","author":"Andres","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2174\/1874285801812010248","article-title":"Detection of Plasmid-Mediated qnr Genes Among the Clinical Quinolone-Resistant Escherichia coli Strains Isolated in Tehran, Iran","volume":"12","author":"Ranjbar","year":"2018","journal-title":"Open Microbiol. J."},{"key":"ref_66","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s13054-014-0480-6","article-title":"Antibiotic stewardship in the intensive care unit","volume":"18","author":"Luyt","year":"2014","journal-title":"Crit. Care"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S538","DOI":"10.1093\/ofid\/ofz360.1339","article-title":"1475. Understanding Prescribing Practices for Uncomplicated Urinary Tract Infections (UTIs) in the Primary Care Setting: A Pilot Study","volume":"6","author":"Pinkerton","year":"2019","journal-title":"Open Forum Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/CMR.00002-11","article-title":"Food animals and antimicrobials: Impacts on human health","volume":"24","author":"Marshall","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_70","unstructured":"Lindmeier, C. (2017). Stop Using Antibiotics in Healthy Animals to Prevent the Spread of Antibiotic Resistance, World Health Organization (WHO)."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e01923-18","DOI":"10.1128\/AAC.01923-18","article-title":"Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates","volume":"63","author":"Tamma","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e01405-18","DOI":"10.1128\/JCM.01405-18","article-title":"Genome-Based Prediction of Bacterial Antibiotic Resistance","volume":"57","author":"Su","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"ref_73","first-page":"8382605","article-title":"Spread of TEM, VIM, SHV, and CTX-M beta-Lactamases in Imipenem-Resistant Gram-Negative Bacilli Isolated from Egyptian Hospitals","volume":"2016","year":"2016","journal-title":"Int. J. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1128\/JCM.41.9.4089-4094.2003","article-title":"Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus","volume":"41","author":"Strommenger","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/jac\/46.4.527","article-title":"Multiplex PCR assays for the detection of clinically relevant antibiotic resistance genes in staphylococci isolated from patients infected after cardiac surgery","volume":"46","author":"Martineau","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/AAC.01223-12","article-title":"Evaluation of an expanded microarray for detecting antibiotic resistance genes in a broad range of gram-negative bacterial pathogens","volume":"57","author":"Card","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1128\/JCM.00765-09","article-title":"Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes","volume":"48","author":"Leinberger","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1128\/AAC.00863-13","article-title":"DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates","volume":"57","author":"Dally","year":"2013","journal-title":"Antimicrob. 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