{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:07:48Z","timestamp":1788577668691,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eastman Institute for Oral Health at the University of Rochester Medical Center","award":["K23DE027412"],"award-info":[{"award-number":["K23DE027412"]}]},{"name":"Eastman Institute for Oral Health at the University of Rochester Medical Center","award":["R01DE031025"],"award-info":[{"award-number":["R01DE031025"]}]},{"name":"NIDCR","award":["K23DE027412"],"award-info":[{"award-number":["K23DE027412"]}]},{"name":"NIDCR","award":["R01DE031025"],"award-info":[{"award-number":["R01DE031025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>This study aimed to evaluate the impact of Nystatin oral rinse on salivary and supragingival microbiota in adults with oral candidiasis and identify predictive factors related to individuals\u2019 responses to Nystatin. The trial involved twenty participants who used 600,000 International Units\/application of Nystatin oral rinse for seven days, four times a day, and were followed up at one week and three months after the rinse. The salivary and plaque microbiome of the participants were assessed via 16S rDNA amplicon sequencing. Overall, salivary and plaque microbiomes remained stable. However, among the participants (53 percent) who responded to Nystatin rinse (defined as free of oral Candida albicans post treatment), Veillonella emerged as a core genus alongside Streptococcus and Actinomyces in supragingival plaque at the 3-month follow-up. Furthermore, statistical models were fit to identify predictive factors of Nystatin rinse success (elimination of C. albicans) or failure (remaining C. albicans). The results revealed that an increased level of salivary Interferon (IFN)-\u03b3-inducible protein (IP-10), also known as C-X-C motif chemokine ligand 10 (CXCL10), was an indicator of a failure of responding to Nystatin rinse. Future clinical trials are warranted to comprehensively assess the impact of antifungal treatment on the oral flora.<\/jats:p>","DOI":"10.3390\/microorganisms11061497","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T02:57:47Z","timestamp":1685933867000},"page":"1497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Nystatin Oral Rinse on Salivary and Supragingival Microbial Community among Adults with Oral Candidiasis"],"prefix":"10.3390","volume":"11","author":[{"given":"Lanxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14627, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14627, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Lee","sequence":"additional","affiliation":[{"name":"Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-9657","authenticated-orcid":false,"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Paster","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Forsyth Institute, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6689-317X","authenticated-orcid":false,"given":"George","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Forsyth Institute, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Fiscella","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Rochester Medical Center, Rochester, NY 14627, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034520956975","article-title":"Critically Appraising the Significance of the Oral Mycobiome","volume":"100","author":"Diaz","year":"2021","journal-title":"J. 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