{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:01:00Z","timestamp":1778544060869,"version":"3.51.4"},"reference-count":66,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005771","name":"Dokuz Eyl\u00fcl University Scientific Research Coordination Unit","doi-asserted-by":"publisher","award":["2019.KB.FEN.014"],"award-info":[{"award-number":["2019.KB.FEN.014"]}],"id":[{"id":"10.13039\/501100005771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Origanum onites (Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of O. onites. In this study, the biochemical composition of the O. onites ethanol extract (OOEt) was analyzed using GC-MS. The antimicrobial activity was investigated using a disk diffusion test and determining minimum inhibitory concentrations (MIC) against 30 microorganism strains, including 28 bacteria (some multidrug-resistant) and 2 fungi. Additionally, the antioxidant activity was evaluated using the DPPH method. The main component identified was carvacrol. OOEt demonstrated antimicrobial activity against a wide range of tested microorganism strains. OOEt displayed the highest activity against E. faecium (a Gram-positive bacterium) at 100 \u00b5L with a 52 mm inhibition zone. Additionally, P. aeruginosa DSMZ 50071 and P. fluorescens P1, which are Gram-negative bacteria, were the most sensitive strains with a 24 mm inhibition zone in 100 \u00b5L of OOEt. The data obtained from A. baumannii (a multidrug-resistant strain) is particularly striking, as higher activity was observed compared to all positive controls. All tested fungal strains showed more effective results than positive controls. The antioxidant activity of OOEt was found to be stronger than that of the positive control, ascorbic acid. This study determined that O. onites has significant antimicrobial and antioxidant potential.<\/jats:p>","DOI":"10.3390\/microorganisms11081987","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T10:57:33Z","timestamp":1690973853000},"page":"1987","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites"],"prefix":"10.3390","volume":"11","author":[{"given":"Kerem","family":"Canli","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science, Dokuz Eyl\u00fcl University, Izmir 35390, T\u00fcrkiye"},{"name":"Fauna and Flora Research and Application Center, Dokuz Eyl\u00fcl University, Izmir 35390, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-4880","authenticated-orcid":false,"given":"Mustafa Eray","family":"Bozyel","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Dokuz Eyl\u00fcl University, Izmir 35390, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-0488","authenticated-orcid":false,"given":"Dilay","family":"Turu","sequence":"additional","affiliation":[{"name":"Department of Biology, Graduate School of Natural and Applied Science, Dokuz Eyl\u00fcl University, Izmir 35390, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-5968","authenticated-orcid":false,"given":"Atakan","family":"Benek","sequence":"additional","affiliation":[{"name":"Department of Biology, Graduate School of Natural and Applied Sciences, Kastamonu University, Kastamonu 37150, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-7641","authenticated-orcid":false,"given":"Ozcan","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Forestry, Yenice Vocational School, \u00c7anakkale Onsekiz Mart University, \u00c7anakkale 17950, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-8071","authenticated-orcid":false,"given":"Ergin Murat","family":"Altuner","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Kastamonu University, Kastamonu 37150, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. 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