{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:58:05Z","timestamp":1769849885285,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["2020R1A2C1011455"],"award-info":[{"award-number":["2020R1A2C1011455"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["HI21C1624"],"award-info":[{"award-number":["HI21C1624"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["RS-2023-00223501"],"award-info":[{"award-number":["RS-2023-00223501"]}]},{"name":"Ministry Of Health and Welfare, Republic of Korea","award":["2020R1A2C1011455"],"award-info":[{"award-number":["2020R1A2C1011455"]}]},{"name":"Ministry Of Health and Welfare, Republic of Korea","award":["HI21C1624"],"award-info":[{"award-number":["HI21C1624"]}]},{"name":"Ministry Of Health and Welfare, Republic of Korea","award":["RS-2023-00223501"],"award-info":[{"award-number":["RS-2023-00223501"]}]},{"name":"National Research Foundation (NRF)","award":["2020R1A2C1011455"],"award-info":[{"award-number":["2020R1A2C1011455"]}]},{"name":"National Research Foundation (NRF)","award":["HI21C1624"],"award-info":[{"award-number":["HI21C1624"]}]},{"name":"National Research Foundation (NRF)","award":["RS-2023-00223501"],"award-info":[{"award-number":["RS-2023-00223501"]}]},{"name":"Hallym University Research Fund","award":["2020R1A2C1011455"],"award-info":[{"award-number":["2020R1A2C1011455"]}]},{"name":"Hallym University Research Fund","award":["HI21C1624"],"award-info":[{"award-number":["HI21C1624"]}]},{"name":"Hallym University Research Fund","award":["RS-2023-00223501"],"award-info":[{"award-number":["RS-2023-00223501"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Extracellular vesicles (EVs) regulate various cellular and immunological functions in human diseases. There is growing interest in the clinical role of microbial EVs in pneumonia. However, there is a lack of research on the correlation between lung microbiome with microbial EVs and the microbiome of other body sites in pneumonia. We investigated the co-occurrence of lung microbiome and plasma microbe-derived EVs (mEVs) in 111 samples obtained from 60 mechanically ventilated patients (41 pneumonia and 19 non-pneumonia cases). The microbial correlation between the two samples was compared between the pneumonia and non-pneumonia cases. Bacterial composition of the plasma mEVs was distinct from that of the lung microbiome. There was a significantly higher correlation between lung microbiome and plasma mEVs in non-pneumonia individuals compared to pneumonia patients. In particular, Acinetobacter and Lactobacillus genera had high correlation coefficients in non-pneumonia patients. This indicates a beneficial effect of mEVs in modulating host lung immune response through EV component transfer.<\/jats:p>","DOI":"10.3390\/microorganisms11092128","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:46:22Z","timestamp":1692665182000},"page":"2128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between the Respiratory Microbiome and Plasma Microbial Extracellular Vesicles in Intubated Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Jinkyeong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Ji","family":"Woo","sequence":"additional","affiliation":[{"name":"Institute of New Frontier Research Team, Hallym University College of Medicine, Chuncheon 24253, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1607-6777","authenticated-orcid":false,"given":"Yoonki","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon 24289, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of New Frontier Research Team, Hallym University College of Medicine, Chuncheon 24253, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-7706","authenticated-orcid":false,"given":"Ji Young","family":"Hong","sequence":"additional","affiliation":[{"name":"Institute of New Frontier Research Team, Hallym University College of Medicine, Chuncheon 24253, Republic of Korea"},{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University Medical Center, Chuncheon 24253, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tcb.2016.11.003","article-title":"Extracellular Vesicles: Unique Intercellular Delivery Vehicles","volume":"27","author":"Maas","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1165\/rcmb.2017-0293TR","article-title":"Extracellular Vesicles: New Players in Lung Immunity","volume":"58","author":"Fujita","year":"2018","journal-title":"Am. 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