{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:22:40Z","timestamp":1768908160674,"version":"3.49.0"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BIOCODEX MICROBIOTA FOUNDATION: National Research Grant Russia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The aim was to evaluate the relationship between gut dysbiosis and hemodynamic changes (hyperdynamic circulation) in cirrhosis, and between hemodynamic changes and complications of this disease. This study included 47 patients with cirrhosis. Stool microbiome was assessed using 16S rRNA gene sequencing. Echocardiography with a simultaneous assessment of blood pressure and heart rate was performed to assess systemic hemodynamics. Patients with hyperdynamic circulation had more severe cirrhosis, lower albumin, sodium and prothrombin levels, higher C-reactive protein, aspartate aminotransferase and total bilirubin levels, and higher incidences of portopulmonary hypertension, ascites, overt hepatic encephalopathy, hypoalbuminemia, hypoprothrombinemia, systemic inflammation, and severe hyperbilirubinemia than patients with normodynamic circulation. Patients with hyperdynamic circulation compared with those with normodynamic circulation had increased abundance of Proteobacteria, Enterobacteriaceae, Bacilli, Streptococcaceae, Lactobacillaceae, Fusobacteria, Micrococcaceae, Intestinobacter, Clostridium sensu stricto, Proteus and Rumicoccus, and decreased abundance of Bacteroidetes, Bacteroidaceae, Holdemanella, and Butyrivibrio. The systemic vascular resistance and cardiac output values correlated with the abundance of Proteobacteria, Enterobacteriaceae, Bacilli, Streptococcaceae, Lactobacillaceae, Micrococcaceae, and Fusobacteria. Heart rate and cardiac output value were negatively correlated with the abundance of Bacteroidetes. The mean pulmonary artery pressure value was positively correlated with the abundance of Proteobacteria and Micrococcaceae, and negatively with the abundance of Holdemanella.<\/jats:p>","DOI":"10.3390\/microorganisms11092202","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:33:25Z","timestamp":1693481605000},"page":"2202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gut Dysbiosis and Hemodynamic Changes as Links of the Pathogenesis of Complications of Cirrhosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Irina","family":"Efremova","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7513-1636","authenticated-orcid":false,"given":"Roman","family":"Maslennikov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 119991 Moscow, Russia"},{"name":"The Interregional Public Organization \u201cScientific Community for the Promotion of the Clinical Study of the Human Microbiome\u201d, 119991 Moscow, Russia"},{"name":"Consultative and Diagnostic Center No. 2, Moscow Health Department, 107564 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Poluektova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 119991 Moscow, Russia"},{"name":"The Interregional Public Organization \u201cScientific Community for the Promotion of the Clinical Study of the Human Microbiome\u201d, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Zharkova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-8207","authenticated-orcid":false,"given":"Anna","family":"Kudryavtseva","sequence":"additional","affiliation":[{"name":"Post-Genomic Research Laboratory, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6493-8378","authenticated-orcid":false,"given":"George","family":"Krasnov","sequence":"additional","affiliation":[{"name":"Post-Genomic Research Laboratory, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-4673","authenticated-orcid":false,"given":"Maria","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Post-Genomic Research Laboratory, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-0889","authenticated-orcid":false,"given":"Elena","family":"Shirokova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6244-1088","authenticated-orcid":false,"given":"Evgenii","family":"Kozlov","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Levshina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 119991 Moscow, Russia"},{"name":"Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Ivashkin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000462974","article-title":"Molecular Mechanisms Leading to Splanchnic Vasodilation in Liver Cirrhosis","volume":"54","author":"Sacerdoti","year":"2017","journal-title":"J. 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