{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:28:16Z","timestamp":1760149696718,"version":"build-2065373602"},"reference-count":71,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Genotype I, the penultimate HBV genotype to date, was granted the status of a bona fide genotype only in the XXIst century after some hesitations. The reason for these hesitations was that genotype I is a complex recombinant virus formed with segments from three original genotypes, A, C, and G. It was estimated that genotype I is responsible for only an infinitesimal fraction (&lt;1.0%) of the chronic HBV infection burden worldwide. Furthermore, most probably due to its recent discovery and rarity, the natural history of infection with genotype I is poorly known in comparison with those of genotypes B or C that predominate in their area of circulation. Overall, genotype I is a minor genotype infecting ethnic minorities. It is endemic to the Southeast Asian Massif or Eastern Zomia, a vast mountainous or hilly region of 2.5 million km2 spreading from Eastern India to China, inhabited by a little more than 100 million persons belonging primarily to ethnic minorities speaking various types of languages (Tibeto-Burman, Austroasiatic, and Tai-Kadai) who managed to escape the authority of central states during historical times. Genotype I consists of two subtypes: I1, present in China, Laos, Thailand, and Vietnam; and I2, encountered in India, Laos, and Vietnam.<\/jats:p>","DOI":"10.3390\/microorganisms11092204","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:33:25Z","timestamp":1693481605000},"page":"2204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concealed for a Long Time on the Marches of Empires: Hepatitis B Virus Genotype I"],"prefix":"10.3390","volume":"11","author":[{"given":"Agn\u00e8s","family":"Marchio","sequence":"first","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Unit\u00e9 \u201cOrganisation Nucl\u00e9aire et Oncogen\u00e8se\u201d, INSERM U993, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philavanh","family":"Sitbounlang","sequence":"additional","affiliation":[{"name":"Centre d\u2019Infectiologie Lao-Christophe M\u00e9rieux (CILM), Vientiane 3888, Laos"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Deharo","sequence":"additional","affiliation":[{"name":"MIVEGEC, Universit\u00e9 Montpellier, CNRS, IRD, 34394 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phimpha","family":"Paboriboune","sequence":"additional","affiliation":[{"name":"Centre d\u2019Infectiologie Lao-Christophe M\u00e9rieux (CILM), Vientiane 3888, Laos"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-1592","authenticated-orcid":false,"given":"Pascal","family":"Pineau","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Unit\u00e9 \u201cOrganisation Nucl\u00e9aire et Oncogen\u00e8se\u201d, INSERM U993, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Velkov, S., Ott, J., Protzer, U., and Michler, T. 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