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The gut microbiota of intermediate hosts is known to influence their physiological functions, but little is known about its composition and role in Biomphalaria snails. To gain insights into the biological characteristics of these freshwater intermediate hosts, we conducted metagenomic sequencing on Biomphalaria straminea and B. glabrata to investigate variations in their gut microbiota. This study revealed that the dominant members of the gut microbiota in B. glabrata belong to the phyla Bacteroidetes and Proteobacteria, which were also found to be the top two most abundant gut bacteria in B. straminea. We identified Firmicutes, Acidovorax and Bosea as distinctive gut microbes in B. straminea, while Aeromonas, Cloacibacterium and Chryseobacterium were found to be dependent features of the B. glabrata gut microbiota. We observed significant differences in the community structures and bacterial functions of the gut microbiota between the two host species. Notably, we found a distinctive richness of antibiotic resistance genes (ARGs) associated with various classes of antibiotics, including bacitracin, chloramphenicol, tetracycline, sulfonamide, penicillin, cephalosporin_ii and cephalosporin_i, fluoroquinolone, aminoglycoside, beta-lactam, multidrug and trimethoprim, in the digestive tracts of the snails. Furthermore, this study revealed the potential correlations between snail gut microbiota and the infection rate of S. mansoni using Spearman correlation analysis. Through metagenomic analysis, our study provided new insights into the gut microbiota of Biomphalaria snails and how it is influenced by host species, thereby enhancing our understanding of variant patterns of gut microbial communities in intermediate hosts. Our findings may contribute to future studies on gastropod\u2013microbe interactions and may provide valuable knowledge for developing snail control strategies to combat schistosomiasis in the future.<\/jats:p>","DOI":"10.3390\/microorganisms11102419","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T01:42:12Z","timestamp":1695865332000},"page":"2419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Metagenomic Analysis Reveals Variations in Gut Microbiomes of the Schistosoma mansoni-Transmitting Snails Biomphalaria straminea and Biomphalaria glabrata"],"prefix":"10.3390","volume":"11","author":[{"given":"Peipei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Provincial Engineering Technology Research Center for Diseases-Vectors Control, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2048-0780","authenticated-orcid":false,"given":"Jinni","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510180, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingrou","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanhong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinghao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongdao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Provincial Engineering Technology Research Center for Diseases-Vectors Control, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Provincial Engineering Technology Research Center for Diseases-Vectors Control, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-8706","authenticated-orcid":false,"given":"Datao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China"},{"name":"Provincial Engineering Technology Research Center for Diseases-Vectors Control, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/S0140-6736(18)33008-3","article-title":"Schistosomiasis","volume":"392","author":"Barnett","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Arican-Goktas, H.D., Ittiprasert, W., Bridger, J.M., and Knight, M. (2014). Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003013"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"744352","DOI":"10.3389\/fcimb.2021.744352","article-title":"Molecular Characterization of Rotifers and Their Potential Use in the Biological Control of Biomphalaria","volume":"11","author":"Lin","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Lin, D., Zeng, X., Sanogo, B., He, P., Xiang, S., Du, S., Zhang, Y., Wang, L., Wan, S., and Zeng, X. (2020). The potential risk of Schistosoma mansoni transmission by the invasive freshwater snail Biomphalaria straminea in South China. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008310"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"569727","DOI":"10.3389\/fimmu.2020.569727","article-title":"Alterations of Gut Microbiome and Metabolite Profiling in Mice Infected by Schistosoma japonicum","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3389\/fimmu.2020.00593","article-title":"Myricetin Possesses Anthelmintic Activity and Attenuates Hepatic Fibrosis via Modulating TGFbeta1 and Akt Signaling and Shifting Th1\/Th2 Balance in Schistosoma japonicum-Infected Mice","volume":"11","author":"Huang","year":"2020","journal-title":"Front. 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Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13071-022-05404-6","article-title":"Fine-scale-mapping of Schistosoma haematobium infections at the school and community levels and intermediate host snail abundance in the north of Pemba Island: Baseline cross-sectional survey findings before the onset of a 3-year intervention study","volume":"15","author":"Trippler","year":"2022","journal-title":"Parasit. Vectors"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00436-014-3780-5","article-title":"Comparative evaluation of Schistosoma mansoni, Schistosoma intercalatum, and Schistosoma haematobium alkaline phosphatase antigenicity by the alkaline phosphatase immunoassay (APIA)","volume":"113","author":"Cesari","year":"2014","journal-title":"Parasitol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chienwichai, P., Tipthara, P., Tarning, J., Limpanont, Y., Chusongsang, P., Chusongsang, Y., Adisakwattana, P., and Reamtong, O. (2021). Metabolomics reveal alterations in arachidonic acid metabolism in Schistosoma mekongi after exposure to praziquantel. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009706"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rahman, M.O., Sassa, M., Parvin, N., Islam, M.R., Yajima, A., and Ota, E. (2021). Diagnostic test accuracy for detecting Schistosoma japonicum and S. mekongi in humans: A systematic review and meta-analysis. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009244"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"910177","DOI":"10.3389\/fcimb.2022.910177","article-title":"Untargeted serum metabolomic profiling for early detection of Schistosoma mekongi infection in mouse model","volume":"12","author":"Chienwichai","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1126\/science.abk2189","article-title":"Immune-microbe interactions early in life: A determinant of health and disease long term","volume":"376","author":"Brodin","year":"2022","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e184321","DOI":"10.1128\/spectrum.01843-21","article-title":"Metagenome-Assembled Genomes Reveal Mechanisms of Carbohydrate and Nitrogen Metabolism of Schistosomiasis-Transmitting Vector Biomphalaria Glabrata","volume":"10","author":"Du","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.cell.2015.11.004","article-title":"Gut Microbiota Orchestrates Energy Homeostasis during Cold","volume":"163","author":"Chevalier","year":"2015","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s40168-020-00925-7","article-title":"Early-life gut dysbiosis linked to juvenile mortality in ostriches","volume":"8","author":"Videvall","year":"2020","journal-title":"Microbiome"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40168-018-0473-9","article-title":"Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure","volume":"6","author":"Zhang","year":"2018","journal-title":"Microbiome"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.cub.2016.05.012","article-title":"Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals","volume":"26","author":"Zhang","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6978","DOI":"10.1038\/s41467-022-34557-2","article-title":"Host biology, ecology and the environment influence microbial biomass and diversity in 101 marine fish species","volume":"13","author":"Minich","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40168-020-00977-9","article-title":"Seasonal shifts in the gut microbiome indicate plastic responses to diet in wild geladas","volume":"9","author":"Baniel","year":"2021","journal-title":"Microbiome"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s40168-021-01113-x","article-title":"Host habitat is the major determinant of the gut microbiome of fish","volume":"9","author":"Kim","year":"2021","journal-title":"Microbiome"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s40168-019-0699-1","article-title":"Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle","volume":"7","author":"Li","year":"2019","journal-title":"Microbiome"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"978402","DOI":"10.3389\/fimmu.2022.978402","article-title":"Rumen and fecal microbiota profiles associated with immunity of young and adult goats","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s13071-021-04900-5","article-title":"Diversity of midgut bacteria in larvae and females of Aedes aegypti and Aedes albopictus from Gampaha District, Sri Lanka","volume":"14","author":"Ranasinghe","year":"2021","journal-title":"Parasit. Vectors"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12974-018-1071-2","article-title":"Chi3l3: A potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis","volume":"15","author":"Wan","year":"2018","journal-title":"J. Neuroinflammation."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00436-017-5472-4","article-title":"Study on the tolerance and adaptation of rats to Angiostrongylus cantonensis infection","volume":"116","author":"Ji","year":"2017","journal-title":"Parasitol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40249-017-0332-0","article-title":"Parasitology should not be abandoned: Data from outpatient parasitological testing in Guangdong, China","volume":"6","author":"Song","year":"2017","journal-title":"Infect. Dis. Poverty."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3389\/fmicb.2015.00860","article-title":"Isolation of aerobic cultivable cellulolytic bacteria from different regions of the gastrointestinal tract of giant land snail Achatina fulica","volume":"6","author":"Pinheiro","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, L.-H., Lv, S., Lu, Y., Bi, D.-Q., Guo, Y.-H., Wu, J.-T., Yue, Z.-Y., Mao, G.-Y., Guo, Z.-X., and Zhang, Y. (2019). Spatial structure of the microbiome in the gut of Pomacea canaliculata. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1661-x"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Chen, L., Li, S., Xiao, Q., Lin, Y., Li, X., Qu, Y., Wu, G., and Li, H. (2021). Composition and diversity of gut microbiota in Pomacea canaliculata in sexes and between developmental stages. BMC Microbiol., 21.","DOI":"10.1186\/s12866-021-02259-2"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40168-022-01298-9","article-title":"Metagenomic insights into the microbe-mediated B and K(2) vitamin biosynthesis in the gastrointestinal microbiome of ruminants","volume":"10","author":"Jiang","year":"2022","journal-title":"Microbiome"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s40168-022-01407-8","article-title":"Human microbiota drives hospital-associated antimicrobial resistance dissemination in the urban environment and mirrors patient case rates","volume":"10","author":"Salazar","year":"2022","journal-title":"Microbiome"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13071-022-05161-6","article-title":"Metagenomics of the midgut microbiome of Rhipicephalus microplus from China","volume":"15","author":"Zhang","year":"2022","journal-title":"Parasit. Vectors"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7718","DOI":"10.1038\/s41467-022-35380-5","article-title":"Microbiome-mediated fructose depletion restricts murine gut colonization by vancomycin-resistant Enterococcus","volume":"13","author":"Isaac","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1007\/s00436-016-5243-7","article-title":"Evaluating the risk of Schistosoma mansoni transmission in mainland China","volume":"115","author":"Qu","year":"2016","journal-title":"Parasitol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1093\/nar\/gkl723","article-title":"MetaGene: Prokaryotic gene finding from environmental genome shotgun sequences","volume":"34","author":"Noguchi","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1264\/jsme2.ME12157","article-title":"De novo semi-alignment of 16S rRNA gene sequences for deep phylogenetic characterization of next generation sequencing data","volume":"28","author":"Avershina","year":"2013","journal-title":"Microbes Environ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S0074-02762002000900013","article-title":"Susceptibility of Biomphalaria straminea (Dunker, 1848) from Serra da Mesa Dam, Goias, Brazil to infection with three strains of Schistosoma mansoni Sambon, 1907","volume":"97","author":"Fernandez","year":"2002","journal-title":"Mem. Inst. Oswaldo. Cruz."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11552","article-title":"Functional interactions between the gut microbiota and host metabolism","volume":"489","author":"Tremaroli","year":"2012","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s40168-023-01635-6","article-title":"Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40168-019-0721-7","article-title":"Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria","volume":"7","author":"Wang","year":"2019","journal-title":"Microbiome"},{"key":"ref_49","first-page":"396","article-title":"Antibiotic resistance genes in the environment: Prioritizing risks","volume":"13","author":"Larsson","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13808","DOI":"10.1038\/s41598-022-14781-y","article-title":"Antibiotic resistance genes of public health importance in livestock and humans in an informal urban community in Nepal","volume":"12","author":"Young","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"15451","DOI":"10.1038\/ncomms15451","article-title":"Whole genome analysis of a schistosomiasis-transmitting freshwater snail","volume":"8","author":"Adema","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1007\/s00436-020-06743-y","article-title":"Mollusk microbiota shift during Angiostrongylus cantonensis infection in the freshwater snail Biomphalaria glabrata and the terrestrial slug Phillocaulis soleiformis","volume":"119","author":"Pereira","year":"2020","journal-title":"Parasitol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Portet, A., Toulza, E., Lokmer, A., Huot, C., Duval, D., Galinier, R., and Gourbal, B. (2021). Experimental Infection of the Biomphalaria glabrata Vector Snail by Schistosoma mansoni Parasites Drives Snail Microbiota Dysbiosis. Microorganisms, 9.","DOI":"10.3390\/microorganisms9051084"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nm.4357","article-title":"Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis","volume":"23","author":"Worthmann","year":"2017","journal-title":"Nat. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1186\/s13071-021-05050-4","article-title":"Bacterial composition of midgut and entire body of laboratory colonies of Aedes aegypti and Aedes albopictus from Southern China","volume":"14","author":"Lin","year":"2021","journal-title":"Parasit. Vectors"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1038\/s41564-019-0560-0","article-title":"Core gut microbial communities are maintained by beneficial interactions and strain variability in fish","volume":"4","author":"Kokou","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/ismej.2015.140","article-title":"The composition of the zebrafish intestinal microbial community varies across development","volume":"10","author":"Stephens","year":"2016","journal-title":"ISME J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e5830","DOI":"10.7717\/peerj.5830","article-title":"Structure, dynamics and predicted functional role of the gut microbiota of the blue (Haliotis fulgens) and yellow (H. corrugata) abalone from Baja California Sur, Mexico","volume":"6","author":"Cicala","year":"2018","journal-title":"PeerJ"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"983660","DOI":"10.3389\/fmicb.2022.983660","article-title":"The influence of species identity and geographic locations on gut microbiota of small rodents","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"906278","DOI":"10.3389\/fmicb.2022.906278","article-title":"Responses of Gut Microbial Community Composition and Function of the Freshwater Gastropod Bellamya aeruginosa to Cyanobacterial Bloom","volume":"13","author":"Lyu","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"105202","DOI":"10.1016\/j.actatropica.2019.105202","article-title":"Intestinal microbiome profiles in Oncomelania hupensis in mainland China","volume":"201","author":"Hao","year":"2020","journal-title":"Acta Trop."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00436-019-06495-4","article-title":"Investigation of defense response and immune priming in Biomphalaria glabrata and Biomphalaria straminea, two species with different susceptibility to Schistosoma mansoni","volume":"119","author":"Brayner","year":"2020","journal-title":"Parasitol. Res."},{"key":"ref_63","first-page":"giac012","article-title":"Genome of the ramshorn snail Biomphalaria straminea\u2014An obligate intermediate host of schistosomiasis","volume":"11","author":"Nong","year":"2022","journal-title":"Gigascience"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"160257","DOI":"10.1016\/j.scitotenv.2022.160257","article-title":"Roles of substrates in removing antibiotics and antibiotic resistance genes in constructed wetlands: A review","volume":"859","author":"Cui","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40168-022-01268-1","article-title":"Geographical resistome profiling in the honeybee microbiome reveals resistance gene transfer conferred by mobilizable plasmids","volume":"10","author":"Sun","year":"2022","journal-title":"Microbiome"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1038\/ncomms3151","article-title":"Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota","volume":"4","author":"Hu","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"105649","DOI":"10.1016\/j.envint.2020.105649","article-title":"Integrated metagenomic and metatranscriptomic profiling reveals differentially expressed resistomes in human, chicken, and pig gut microbiomes","volume":"138","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2022442","DOI":"10.1080\/19490976.2021.2022442","article-title":"High-sugar, high-fat, and high-protein diets promote antibiotic resistance gene spreading in the mouse intestinal microbiota","volume":"14","author":"Tan","year":"2022","journal-title":"Gut Microbes."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"119934","DOI":"10.1016\/j.envpol.2022.119934","article-title":"Composition and distribution of bacterial communities and antibiotic resistance genes in fish of four mariculture systems","volume":"311","author":"Zhang","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.chom.2016.04.021","article-title":"Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes","volume":"19","author":"Dutra","year":"2016","journal-title":"Cell Host Microbe."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.aan5478","article-title":"Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria","volume":"357","author":"Wang","year":"2017","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Dong, Y., Manfredini, F., and Dimopoulos, G. (2009). Implication of the mosquito midgut microbiota in the defense against malaria parasites. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000423"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cois.2020.01.004","article-title":"The gut microbiota\u2014Brain axis of insects","volume":"39","author":"Liberti","year":"2020","journal-title":"Curr. Opin. Insect Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1016\/j.neuron.2021.09.036","article-title":"Microbiota-brain interactions: Moving toward mechanisms in model organisms","volume":"109","author":"Nagpal","year":"2021","journal-title":"Neuron"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/11\/10\/2419\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:00:14Z","timestamp":1760130014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/11\/10\/2419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":74,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["microorganisms11102419"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms11102419","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]}}}