{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:41:53Z","timestamp":1790178113741,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health and Medical Research Fund (HMRF), Commissioned Research on Control of Infectious Disease (Phase IV), Health Bureau, Hong Kong SAR Government","award":["CID-HKU1-16"],"award-info":[{"award-number":["CID-HKU1-16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Staphylococcus argenteus is a novel Staphylococcus species derived from Staphylococcus aureus. Information on the prevalence and genetic characteristics of invasive S. argenteus in Asia is limited. In this study, 275 invasive S. aureus complex strains were retrieved from blood culture specimens in Hong Kong and re-analyzed using MALDI-TOF mass spectrometry and an in-house multiplex real-time PCR for S. argenteus. The prevalence of invasive S. argenteus in Hong Kong was found to be 4.0% (11\/275). These strains were primarily susceptible to commonly used antibiotics, except penicillin. Whole-genome sequencing revealed the circulation of three S. argenteus genotypes (ST-2250, ST-1223, and ST-2854) in Hong Kong, with ST-2250 and ST-1223 being the predominant genotypes. The local ST-2250 and ST-1223 strains showed close phylogenetic relationships with isolates from mainland China. Antimicrobial-resistant genes (fosB, tet-38, mepA, blaI, blaZ) could be found in nearly all local S. argenteus strains. The ST-1223 and ST-2250 genotypes carried multiple staphylococcal enterotoxin genes that could cause food poisoning and toxic shock syndrome. The CRISPR\/Cas locus was observed only in the ST-2250 strains. This study provides the first report on the molecular epidemiology of invasive S. argenteus in Hong Kong, and further analysis is needed to understand its transmission reservoir.<\/jats:p>","DOI":"10.3390\/microorganisms11102435","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:50:26Z","timestamp":1695887426000},"page":"2435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7510-1696","authenticated-orcid":false,"given":"Jonathan H. K.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Microbiology, Queen Mary Hospital, Hong Kong SAR, China"},{"name":"Department of Microbiology, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi-Yi","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Queen Mary Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M. C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Yung","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1765-7706","authenticated-orcid":false,"given":"Vincent C. C.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Queen Mary Hospital, Hong Kong SAR, China"},{"name":"Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1128\/JCM.00122-09","article-title":"Phylogenetically distinct Staphylococcus aureus lineage prevalent among indigenous communities in northern Australia","volume":"47","author":"Ng","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/gbe\/evr078","article-title":"A very early-branching Staphylococcus aureus lineage lacking the carotenoid pigment staphyloxanthin","volume":"3","author":"Holt","year":"2011","journal-title":"Genome Biol. Evol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1128\/JCM.00836-06","article-title":"Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities","volume":"44","author":"McDonald","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1099\/ijs.0.062752-0","article-title":"Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: The non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov","volume":"65","author":"Tong","year":"2015","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jinf.2021.08.040","article-title":"Staphylococcus argenteus transmission among healthy Royal Marines: A molecular epidemiology case-study","volume":"83","author":"Jauneikaite","year":"2021","journal-title":"J. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jiac.2019.07.011","article-title":"Low incidence of Staphylococcus argenteus bacteremia in Hiroshima, Japan","volume":"26","author":"Kitagawa","year":"2020","journal-title":"J. Infect. Chemother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1128\/JCM.03049-14","article-title":"Clinical and molecular epidemiology of Staphylococcus argenteus infections in Thailand","volume":"53","author":"Thaipadungpanit","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Rocha Balzan, L.D.L., Rossato, A.M., Riche, C.V.W., Cantarelli, V.V., D\u2019Azevedo, P.A., Valerio de Lima, A., Rodrigues, B., Franca, E.S.I.L.A., Dias, C.A.G., and Sampaio, J.L.M. (2023). Staphylococcus argenteus Infections, Brazil. Microbiol. Spectr., 11.","DOI":"10.1128\/spectrum.01179-22"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijantimicag.2018.08.017","article-title":"High mortality impact of Staphylococcus argenteus on patients with community-onset staphylococcal bacteraemia","volume":"52","author":"Chen","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s10096-020-03950-4","article-title":"Human infections caused by Staphylococcus argenteus in Germany: Genetic characterisation and clinical implications of novel species designation","volume":"39","author":"Alhussein","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cmi.2019.02.028","article-title":"Implications of identifying the recently defined members of the Staphylococcus aureus complex S. argenteus and S. schweitzeri: A position paper of members of the ESCMID Study Group for Staphylococci and Staphylococcal Diseases (ESGS)","volume":"25","author":"Becker","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/mdr.2022.0191","article-title":"Molecular Epidemiological Characterization of Staphylococcus aureus and Staphylococcus argenteus Clinical Isolates from a National Tertiary Care Hospital in Myanmar: Co-Isolation of Multiple Clones and Identification of Novel Staphylocoagulase Genotype","volume":"29","author":"Kyaw","year":"2023","journal-title":"Microb. Drug Resist."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2217\/fmb-2016-0017","article-title":"Identification of Staphylococcus argenteus in Eastern China based on a nonribosomal peptide synthetase (NRPS) gene","volume":"11","author":"Zhang","year":"2016","journal-title":"Future Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wu, S., Pang, R., Huang, J., Zhang, F., Cai, Z., Zhang, J., Chen, M., Xue, L., Gu, Q., and Wang, J. (2021). Evolutionary Divergence of the Novel Staphylococcal Species Staphylococcus argenteus. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.769642"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e00802-17","DOI":"10.1128\/mBio.00802-17","article-title":"Evolution of the Staphylococcus argenteus ST2250 Clone in Northeastern Thailand Is Linked with the Acquisition of Livestock-Associated Staphylococcal Genes","volume":"8","author":"Moradigaravand","year":"2017","journal-title":"mBio"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wu, S., Huang, J., Zhang, F., Dai, J., Pang, R., Zhang, J., Zeng, H., Gu, Q., Zhang, S., and Zhang, Y. (2020). Staphylococcus argenteus isolated from retail foods in China: Incidence, antibiotic resistance, biofilm formation and toxin gene profile. Food Microbiol., 91.","DOI":"10.1016\/j.fm.2020.103531"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rong, D., Liu, Z., Huang, J., Zhang, F., Wu, Q., Dai, J., Li, Y., Zhao, M., Li, Q., and Zhang, J. (2023). Prevalence and characterization of Staphylococcus aureus and Staphylococcus argenteus isolated from rice and flour products in Guangdong, China. Int. J. Food Microbiol., 406.","DOI":"10.1016\/j.ijfoodmicro.2023.110348"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wakabayashi, Y., Takemoto, K., Iwasaki, S., Yajima, T., Kido, A., Yamauchi, A., Kuroiwa, K., Kumai, Y., Yoshihara, S., and Tokumoto, H. (2022). Isolation and characterization of Staphylococcus argenteus strains from retail foods and slaughterhouses in Japan. Int. J. Food Microbiol., 363.","DOI":"10.1016\/j.ijfoodmicro.2021.109503"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"21154","DOI":"10.2807\/1560-7917.ES2015.20.23.21154","article-title":"Community-acquired infections due to Staphylococcus argenteus lineage isolates harbouring the Panton-Valentine leucocidin, France, 2014","volume":"20","author":"Dupieux","year":"2015","journal-title":"Eurosurveillance"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3201\/eid2410.180727","article-title":"Community-Acquired Staphylococcus argenteus Sequence Type 2250 Bone and Joint Infection, France, 2017","volume":"24","author":"Rigaill","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"458.e411","DOI":"10.1016\/j.cmi.2016.01.008","article-title":"Comparison of community-onset Staphylococcus argenteus and Staphylococcus aureus sepsis in Thailand: A prospective multicentre observational study","volume":"22","author":"Chantratita","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jiang, B., You, B., Tan, L., Yu, S., Li, H., Bai, G., Li, S., Rao, X., Xie, Z., and Shi, X. (2018). Clinical Staphylococcus argenteus Develops to Small Colony Variants to Promote Persistent Infection. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01347"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.2147\/IDR.S373352","article-title":"The First Case Report of Community-Acquired Infective Endocarditis Due to Sequence Type 1223 Staphylococcus argenteus Complicated with Convexity Subarachnoid Hemorrhage","volume":"15","author":"Hirai","year":"2022","journal-title":"Infect. Drug Resist."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jiac.2020.05.003","article-title":"Thoracic aortic mycotic aneurysm due to Staphylococcus argenteus: A case report","volume":"26","author":"Mitsutake","year":"2020","journal-title":"J. Infect. Chemother."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.7150\/jbji.44848","article-title":"Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: A case presentation","volume":"5","author":"Soderquist","year":"2020","journal-title":"J. Bone Jt. Infect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijfoodmicro.2017.09.005","article-title":"Food poisoning outbreak in Tokyo, Japan caused by Staphylococcus argenteus","volume":"262","author":"Suzuki","year":"2017","journal-title":"Int. J. Food Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijfoodmicro.2017.10.022","article-title":"Staphylococcal food poisoning caused by Staphylococcus argenteus harboring staphylococcal enterotoxin genes","volume":"265","author":"Wakabayashi","year":"2018","journal-title":"Int. J. Food Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hansen, T.A., Bartels, M.D., Hogh, S.V., Dons, L.E., Pedersen, M., Jensen, T.G., Kemp, M., Skov, M.N., Gumpert, H., and Worning, P. (2017). Whole Genome Sequencing of Danish Staphylococcus argenteus Reveals a Genetically Diverse Collection with Clear Separation from Staphylococcus aureus. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.01512"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhang, D.F., Zhi, X.Y., Zhang, J., Paoli, G.C., Cui, Y., Shi, C., and Shi, X. (2017). Preliminary comparative genomics revealed pathogenic potential and international spread of Staphylococcus argenteus. BMC Genom., 18.","DOI":"10.1186\/s12864-017-4149-9"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/21505594.2019.1620062","article-title":"Staphylococcus argenteus and Staphylococcus schweitzeri are cytotoxic to human cells in vitro due to high expression of alpha-hemolysin Hla","volume":"10","author":"Johansson","year":"2019","journal-title":"Virulence"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1128\/JCM.02470-20","article-title":"Phenotypic and Genomic Profiling of Staphylococcus argenteus in Canada and the United States and Recommendations for Clinical Result Reporting","volume":"59","author":"Eshaghi","year":"2021","journal-title":"J. Clin. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.2217\/fmb-2018-0015","article-title":"Accurate differentiation of novel Staphylococcus argenteus from Staphylococcus aureus using MALDI-TOF MS","volume":"13","author":"Chen","year":"2018","journal-title":"Future Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.14202\/vetworld.2018.423-430","article-title":"Molecular typing of Staphylococcus aureus based on coagulase gene","volume":"11","author":"Javid","year":"2018","journal-title":"Vet. World"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Watanabe, S., Ito, T., Sasaki, T., Li, S., Uchiyama, I., Kishii, K., Kikuchi, K., Skov, R.L., and Hiramatsu, K. (2009). Genetic diversity of staphylocoagulase genes (coa): Insight into the evolution of variable chromosomal virulence factors in Staphylococcus aureus. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005714"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1086\/655901","article-title":"Are host genetics the predominant determinant of persistent nasal Staphylococcus aureus carriage in humans?","volume":"202","author":"Ruimy","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Aung, M.S., Urushibara, N., Kawaguchiya, M., Sumi, A., Takahashi, S., Ike, M., Ito, M., Habadera, S., and Kobayashi, N. (2019). Molecular Epidemiological Characterization of Staphylococcus argenteus Clinical Isolates in Japan: Identification of Three Clones (ST1223, ST2198, and ST2550) and a Novel Staphylocoagulase Genotype XV. Microorganisms, 7.","DOI":"10.3390\/microorganisms7100389"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1289.e1285","DOI":"10.1016\/j.cmi.2019.06.003","article-title":"Transmission events and antimicrobial susceptibilities of methicillin-resistant Staphylococcus argenteus in Stockholm","volume":"25","author":"Giske","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Aung, M.S., Urushibara, N., Kawaguchiya, M., Hirose, M., Ike, M., Ito, M., and Kobayashi, N. (2021). Distribution of Virulence Factors and Resistance Determinants in Three Genotypes of Staphylococcus argenteus Clinical Isolates in Japan. Pathogens, 10.","DOI":"10.3390\/pathogens10020163"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Witteveen, S., Hendrickx, A.P.A., de Haan, A., Notermans, D.W., Landman, F., van Santen-Verheuvel, M.G., de Greeff, S.C., Kuijper, E.J., van Maarseveen, N.M., and Vainio, S. (2022). Genetic Characteristics of Methicillin-Resistant Staphylococcus argenteus Isolates Collected in the Dutch National MRSA Surveillance from 2008 to 2021. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.01035-22"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Goswami, C., Fox, S., Holden, M., Leanord, A., and Evans, T.J. (2021). Genomic Analysis of Global Staphylococcus argenteus Strains Reveals Distinct Lineages with Differing Virulence and Antibiotic Resistance Gene Content. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.795173"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1128\/JCM.00488-13","article-title":"Evaluation of the LightCycler methicillin-resistant Staphylococcus aureus (MRSA) advanced test for detection of MRSA nasal colonization","volume":"51","author":"Yam","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1128\/JCM.00389-14","article-title":"Multiplex real-time PCR assay for rapid detection of methicillin-resistant staphylococci directly from positive blood cultures","volume":"52","author":"Wang","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Prjibelski, A., Antipov, D., Meleshko, D., Lapidus, A., and Korobeynikov, A. (2020). Using SPAdes De Novo Assembler. Curr. Protoc. Bioinform., 70.","DOI":"10.1002\/cpbi.102"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Walker, B.J., Abeel, T., Shea, T., Priest, M., Abouelliel, A., Sakthikumar, S., Cuomo, C.A., Zeng, Q., Wortman, J., and Young, S.K. (2014). Pilon: An integrated tool for comprehensive microbial variant detection and genome assembly improvement. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112963"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: Rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era","volume":"37","author":"Minh","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12728","DOI":"10.1038\/s41598-021-91456-0","article-title":"AMRFinderPlus and the Reference Gene Catalog facilitate examination of the genomic links among antimicrobial resistance, stress response, and virulence","volume":"11","author":"Feldgarden","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"D687","DOI":"10.1093\/nar\/gky1080","article-title":"VFDB 2019: A comparative pathogenomic platform with an interactive web interface","volume":"47","author":"Liu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"W246","DOI":"10.1093\/nar\/gky425","article-title":"CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins","volume":"46","author":"Couvin","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Aung, M.S., San, T., Aye, M.M., Mya, S., Maw, W.W., Zan, K.N., Htut, W.H.W., Kawaguchiya, M., Urushibara, N., and Kobayashi, N. (2017). Prevalence and Genetic Characteristics of Staphylococcus aureus and Staphylococcus argenteus Isolates Harboring Panton-Valentine Leukocidin, Enterotoxins, and TSST-1 Genes from Food Handlers in Myanmar. Toxins, 9.","DOI":"10.3390\/toxins9080241"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4269\/ajtmh.16-0746","article-title":"Molecular Epidemiology of Staphylococcus aureus Skin and Soft Tissue Infections in the Lao People\u2019s Democratic Republic","volume":"97","author":"Yeap","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s10096-016-2632-x","article-title":"Low occurrence of the new species Staphylococcus argenteus in a Staphylococcus aureus collection of human isolates from Belgium","volume":"35","author":"Argudin","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1099\/jmm.0.000760","article-title":"Methicillin-resistant Staphylococcus argenteus misidentified as methicillin-resistant Staphylococcus aureus emerging in western Sweden","volume":"67","author":"Karami","year":"2018","journal-title":"J. Med. Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/1469-0691.12702","article-title":"Staphylococcus aureus \u2018Down Under\u2019: Contemporary epidemiology of S. aureus in Australia, New Zealand, and the South West Pacific","volume":"20","author":"Williamson","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Hsu, J.C., Wan, T.W., Lee, H., Wang, X.M., Lin, Y.T., Jung, C.J., Lee, T.F., Hsueh, P.R., and Teng, L.J. (2020). Heterogeneity of Molecular Characteristics among Staphylococcus argenteus Clinical Isolates (ST2250, ST2793, ST1223, and ST2198) in Northern Taiwan. Microorganisms, 8.","DOI":"10.3390\/microorganisms8081157"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lozano, C., Fernandez-Fernandez, R., Ruiz-Ripa, L., Gomez, P., Zarazaga, M., and Torres, C. (2020). Human mecC-Carrying MRSA: Clinical Implications and Risk Factors. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101615"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.pathol.2020.11.006","article-title":"Absence of mecC methicillin-resistant Staphylococcus aureus in a tertiary hospital in Singapore","volume":"53","author":"Chew","year":"2021","journal-title":"Pathology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1021\/bi4015852","article-title":"Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus","volume":"53","author":"Thompson","year":"2014","journal-title":"Biochemistry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1128\/IAI.00723-15","article-title":"Role of the Tet38 Efflux Pump in Staphylococcus aureus Internalization and Survival in Epithelial Cells","volume":"83","author":"Bolduc","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1128\/AAC.49.5.1857-1864.2005","article-title":"Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein","volume":"49","author":"Kaatz","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Pence, M.A., Haste, N.M., Meharena, H.S., Olson, J., Gallo, R.L., Nizet, V., and Kristian, S.A. (2015). Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136605"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3390\/toxins2082177","article-title":"Staphylococcal enterotoxins","volume":"2","author":"Pinchuk","year":"2010","journal-title":"Toxins"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/11\/10\/2435\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:01:00Z","timestamp":1760130060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/11\/10\/2435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":63,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["microorganisms11102435"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms11102435","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]}}}