{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:21:45Z","timestamp":1783524105163,"version":"3.55.0"},"reference-count":19,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The clinical characteristics and epidemiology of Q fever in the Tropics are poorly described. We performed a retrospective cohort study of hospitalized cases between 2004 and 2017 in Reunion Island. Acute Q fever was defined in presence of a positive serology (phase II IgG \u2265 200 and phase II IgM \u2265 50), or a seroconversion (4-fold increase in phase II IgG between paired samples), or a positive PCR (blood or serum). Forty-two cases matched the diagnostic criteria. The most common clinical manifestations were fever (85.7%) and pulmonary symptoms (61.9%), including pneumonia (45.2%). Ninety percent of the patients were living in a farming area. Cumulative incidence was estimated at 9.3 per 100,000 inhabitants (95%CI: 6.4\u201312.1) with cases diagnosed yearly all throughout the study period except in 2006. Together with the seroprevalence figures, these data suggest that Q fever reaches low to moderate endemic levels on Reunion Island. As previously reported, pulmonary symptoms are in the foreground.<\/jats:p>","DOI":"10.3390\/microorganisms11102485","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:47:52Z","timestamp":1696405672000},"page":"2485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Epidemiological Aspects of Acute Q Fever in Reunion Island over Fourteen Years: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Alexandra","family":"Aubin","sequence":"first","affiliation":[{"name":"Service des Maladies Infectieuses\u2014Dermatologie, Centre Hospitalier Universitaire (CHU) R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-3407","authenticated-orcid":false,"given":"Carole","family":"Eldin","sequence":"additional","affiliation":[{"name":"Comit\u00e9 de Lutte Contre les Infections Nosocomiales (CLIN), H\u00f4pital Nord, Chemin des Bourr\u00e9ly, 13015 Marseille, France"},{"name":"Unit\u00e9 des Virus Emergents (UVE), Aix-Marseille Universit\u00e9, IRD 190 INSERM 1207 EFS-IRBA, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00ebl","family":"Zemali","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, CHU R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Jaubert","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, CHU R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-1417","authenticated-orcid":false,"given":"Yatrika","family":"Koumar","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses\u2014Dermatologie, Centre Hospitalier Universitaire (CHU) R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Moiton","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses-M\u00e9decine Interne, CHU R\u00e9union, 97400 Saint Denis, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Poubeau","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses\u2014Dermatologie, Centre Hospitalier Universitaire (CHU) R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Braunberger","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Thoracique, CHU R\u00e9union, 97400 Saint Denis, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3276-5919","authenticated-orcid":false,"given":"Patrick","family":"G\u00e9rardin","sequence":"additional","affiliation":[{"name":"Inserm CIC1410, CHU R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bertolotti","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses\u2014Dermatologie, Centre Hospitalier Universitaire (CHU) R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"},{"name":"Inserm CIC1410, CHU R\u00e9union, BP 350, 97448 Saint Pierre, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CMR.00045-16","article-title":"From Q Fever to Coxiella burnetii Infection: A Paradigm Change","volume":"30","author":"Eldin","year":"2017","journal-title":"Clin. 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