{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:33:53Z","timestamp":1780565633598,"version":"3.54.1"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["20210302123356"],"award-info":[{"award-number":["20210302123356"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different metal ions, including Fe(II\/III), Ni(II), Cu(II) and Zn(II), were evaluated for their antimycobacterial activities and their anti-biofilm activities. Some derivatives showed antimycobacterial activities, especially in biofilm growth conditions. For example, 20\u2013100 \u00b5M of HA10Fe2, HA10FeCl, HA10Fe3, HA10Ni2 or HA10Cu2 inhibited Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium marinum biofilm development. HA10Fe2, HA12Fe2 and HA12FeCl could even attack pre-formed Pseudomonas aeruginosa biofilms at higher concentrations (around 300 \u00b5M). The phthiocerol dimycocerosate (PDIM)-deficient Mycobacterium tuberculosis H37Ra was more sensitive to the ion complexes of HA compared to other mycobacterial strains. Furthermore, HA10FeCl could increase the susceptibility of Mycobacterium bovis BCG to vancomycin. Proteomic profiles showed that the potential targets of HA10FeCl were mainly related to mycobacterial stress adaptation, involving cell wall lipid biosynthesis, drug resistance and tolerance and siderophore metabolism. This study provides new insights regarding the antimycobacterial activities of HA and their complexes, especially about their potential anti-biofilm activities.<\/jats:p>","DOI":"10.3390\/microorganisms11102611","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:54:35Z","timestamp":1698040475000},"page":"2611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II\/III), Nickel(II), Copper(II) and Zinc(II) Complexes"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-4028","authenticated-orcid":false,"given":"Dong","family":"Yang","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Shanxi Provincial People\u2019s Hospital, Affiliated of Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Shanxi Provincial People\u2019s Hospital, Affiliated of Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima Sory","family":"Sow","sequence":"additional","affiliation":[{"name":"Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Universit\u00e9 Libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Liang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Shanxi Provincial People\u2019s Hospital, Affiliated of Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efma","family":"El Manssouri","sequence":"additional","affiliation":[{"name":"Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Universit\u00e9 Libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Gelbcke","sequence":"additional","affiliation":[{"name":"Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Universit\u00e9 Libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Dong","sequence":"additional","affiliation":[{"name":"Core Laboratory, Shanxi Provincial People\u2019s Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan 030012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Dufrasne","sequence":"additional","affiliation":[{"name":"Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Universit\u00e9 Libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7588-5462","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Universit\u00e9 Libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongshan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanxi Kidney Disease Institute, The Affiliated People\u2019s Hospital of Shanxi Medical University, Shanxi Provincial People\u2019s Hospital, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). 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