{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T06:59:37Z","timestamp":1780815577412,"version":"3.54.1"},"reference-count":105,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal Resources of the Hospital Infanttil de M\u00e9xico Federico G\u00f3mez","award":["HIM\/2017\/010 SSA 1305"],"award-info":[{"award-number":["HIM\/2017\/010 SSA 1305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Dysbiosis plays an important role in the development of bacterial infections in the gastric mucosa, particularly Helicobacter pylori. The international guidelines for the treatment of H. pylori infections suggest standard triple therapy (STT). Nevertheless, because of the increasing resistance rates to clarithromycin, metronidazole has been widely considered in several countries. Unfortunately, the non-justified administration of antibiotics induces dysbiosis in the target organ. We characterized the gastric microbiota of patients diagnosed with follicular gastropathy and pangastropathy attributed to H. pylori infection, before and after the administration of STT with metronidazole. Dominant relative abundances of Cutibacterium were observed in pre-treatment patients, whereas H. pylori was observed at &lt;11%, suggesting the multifactor property of the disease. The correlation of Cutibacterium acnes and H. pylori with gastric infectious diseases was also evaluated using quantitative real-time polymerase chain reaction. The dominance of C. acnes over H. pylori was observed in gastritis, gastropathies, and non-significant histological alterations. None of the microorganisms were detected in the intestinal metaplasia. Post-treatment alterations revealed an increase in the relative abundances of Staphylococcus, Pseudomonas, and Klebsiella. Non-H. pylori gastrointestinal bacteria can be associated with the initiation and development of gastric diseases, such as pathobiont C. acnes.<\/jats:p>","DOI":"10.3390\/microorganisms11112748","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:10:43Z","timestamp":1699841443000},"page":"2748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dysbiosis by Eradication of Helicobacter pylori Infection Associated with Follicular Gastropathy and Pangastropathy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2223-226X","authenticated-orcid":false,"given":"Uriel","family":"Gomez-Ramirez","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Enfermedades Infecciosas, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"},{"name":"Posgrado en Ciencias Quimicobiol\u00f3gicas, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-0646","authenticated-orcid":false,"given":"Carolina G.","family":"Nolasco-Romero","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Enfermedades Infecciosas, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"},{"name":"Posgrado en Ciencias Quimicobiol\u00f3gicas, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli","family":"Contreras-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-4258","authenticated-orcid":false,"given":"Gerardo","family":"Zu\u00f1iga","sequence":"additional","affiliation":[{"name":"Laboratorio de Variaci\u00f3n Biol\u00f3gica y Evoluci\u00f3n, Departamento de Zoolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-4125","authenticated-orcid":false,"given":"Sandra","family":"Mendoza-Elizalde","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Enfermedades Infecciosas, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-5228","authenticated-orcid":false,"given":"Francisco-Javier","family":"Prado-Galbarro","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"P\u00e9rez Aguilar","sequence":"additional","affiliation":[{"name":"Servicio de Endoscop\u00eda Gastrointestinal, Hospital General Dr. Fernando Quiroz, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 01140, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan Elihu","family":"Pedraza Tinoco","sequence":"additional","affiliation":[{"name":"Clinica Medizama Tulum, Tulum 77760, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Valencia-Mayoral","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda Cl\u00ednica y Experimental, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-7260","authenticated-orcid":false,"given":"Norma","family":"Vel\u00e1zquez-Guadarrama","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Enfermedades Infecciosas, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"ref_1","first-page":"3","article-title":"Histopathologic diagnosis of gastritis and gastropathy: A narrative review","volume":"6","author":"Zhang","year":"2022","journal-title":"Dig. 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