{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:14:54Z","timestamp":1767910494674,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hospital Regional de Alta Especialidad de Ixtapaluca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Brachybacterium conglomeratum, traditionally considered an environmental bacterium, has recently garnered attention for its potential involvement in human health. While prior research hinted at its pathogenic role in humans, our study aims to determine its prevalence and associations in diverse clinical contexts. We examined vaginal swabs from three distinct patient groups: patients with low-grade squamous intraepithelial lesions (LSIL), patients with cervicovaginal infections, and patients with a history of precancerous lesions undergoing follow-up. B. conglomeratum was present in all three patient groups, with the highest prevalence observed in the LSIL group. Statistically significant associations were primarily identified in the LSIL group, where B. conglomeratum was present in 60% of cases. Notably, the LSIL group exhibited coinfections with multiple high-risk oncogenotypes of human papillomavirus (HPV), suggesting potential synergistic effects, and understanding these microbial relationships and their influence on viral persistence, particularly with HPV, holds promise for mitigating HPV-related carcinogenesis. Furthermore, Gardnerella vaginalis and Atopobium vaginae were frequently detected in this group, along with Ureaplasma parvum as the predominant sexually transmitted bacterium. In all cases, B. conglomeratum was found in association with these microorganisms rather than as a sole pathogen. This coexistence underscores the intricate microbial interactions within cervicovaginal infections and precancerous lesions. This study marks the first report of B. conglomeratum prevalence in women with these clinical conditions.<\/jats:p>","DOI":"10.3390\/microorganisms11112769","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:47:48Z","timestamp":1700009268000},"page":"2769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Brachybacterium conglomeratum Is Associated with Cervicovaginal Infections and Human Papilloma Virus in Cervical Disease of Mexican Female Patients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-5896","authenticated-orcid":false,"given":"Iliana Alejandra","family":"Cort\u00e9s-Ort\u00edz","sequence":"first","affiliation":[{"name":"Genetic and Molecular Diagnostic Laboratory, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-6248","authenticated-orcid":false,"given":"Jonathan","family":"Puente-Rivera","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiedaana","family":"Ordaz-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Genetic and Molecular Diagnostic Laboratory, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-8438","authenticated-orcid":false,"given":"Alejandra Yareth","family":"Bonilla-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Escuela Nacional de Medicina y Homeopatia, Instituto Polit\u00e9cnico Nacional, Av. Guillermo Massieu Helguera 239, La Pur\u00edsima Ticom\u00e1n, Gustavo A. Madero, Mexico City 07320, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-3126","authenticated-orcid":false,"given":"Paula","family":"Figueroa-Arredondo","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Politecnico Nacional, Salvador Diaz Mir\u00f3n esq. Plan de San Luis S\/N, Miguel Hidalgo, Casco de Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Serrano-Bello","sequence":"additional","affiliation":[{"name":"Servicio de Unidad Patol\u00f3gica, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9817-6183","authenticated-orcid":false,"given":"Eduardo","family":"Garc\u00eda-Moncada","sequence":"additional","affiliation":[{"name":"Genetic and Molecular Diagnostic Laboratory, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Acosta-Altamirano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Salud, Hospital de Alta Especialidad Ixtapaluca, Carr Federal M\u00e9xico-Puebla Km 34.5, Ixtapaluca 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Ernesto","family":"Artigas-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Genetic and Molecular Diagnostic Laboratory, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-0051","authenticated-orcid":false,"given":"Juan Carlos","family":"Bravata-Alc\u00e1ntara","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Salud, Hospital de Alta Especialidad Ixtapaluca, Carr Federal M\u00e9xico-Puebla Km 34.5, Ixtapaluca 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-592X","authenticated-orcid":false,"given":"M\u00f3nica","family":"Sierra-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Salud, Hospital de Alta Especialidad Ixtapaluca, Carr Federal M\u00e9xico-Puebla Km 34.5, Ixtapaluca 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.22201\/fm.24484865e.2018.61.6.02","article-title":"Microbioma humano","volume":"61","year":"2018","journal-title":"Rev. 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