{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:26:17Z","timestamp":1775600777690,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Multi-dimensional Evaluation of Traditional Chinese Medicine Resources with Characteristics in Southwest China","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}]},{"name":"Multi-dimensional Evaluation of Traditional Chinese Medicine Resources with Characteristics in Southwest China","award":["2022C001"],"award-info":[{"award-number":["2022C001"]}]},{"name":"Multi-dimensional Evaluation of Traditional Chinese Medicine Resources with Characteristics in Southwest China","award":["81891012"],"award-info":[{"award-number":["81891012"]}]},{"name":"Multi-dimensional Evaluation of Traditional Chinese Medicine Resources with Characteristics in Southwest China","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}]},{"name":"Multi-dimensional Evaluation and Product Development Innovation Team of Characteristic Chinese Medicine Resources in Southwest China","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}]},{"name":"Multi-dimensional Evaluation and Product Development Innovation Team of Characteristic Chinese Medicine Resources in Southwest China","award":["2022C001"],"award-info":[{"award-number":["2022C001"]}]},{"name":"Multi-dimensional Evaluation and Product Development Innovation Team of Characteristic Chinese Medicine Resources in Southwest China","award":["81891012"],"award-info":[{"award-number":["81891012"]}]},{"name":"Multi-dimensional Evaluation and Product Development Innovation Team of Characteristic Chinese Medicine Resources in Southwest China","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}]},{"name":"National Natural Science Foundation of China","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}]},{"name":"National Natural Science Foundation of China","award":["2022C001"],"award-info":[{"award-number":["2022C001"]}]},{"name":"National Natural Science Foundation of China","award":["81891012"],"award-info":[{"award-number":["81891012"]}]},{"name":"National Natural Science Foundation of China","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}]},{"name":"Regional Joint Fund of National Natural Science Foundation of China","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}]},{"name":"Regional Joint Fund of National Natural Science Foundation of China","award":["2022C001"],"award-info":[{"award-number":["2022C001"]}]},{"name":"Regional Joint Fund of National Natural Science Foundation of China","award":["81891012"],"award-info":[{"award-number":["81891012"]}]},{"name":"Regional Joint Fund of National Natural Science Foundation of China","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The abnormal proliferation of Cutibacterium acnes is the main cause of acne vulgaris. Natural antibacterial plant extracts have gained great interest due to the efficacy and safety of their use in skin care products. Bletilla striata is a common externally used traditional Chinese medicine, and several of its isolated stilbenes were reported to exhibit good antibacterial activity. In this study, the antimicrobial activity of stilbenes from B. striata (BSS) against C. acnes and its potential effect on cell membrane were elucidated by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), bacterial growth curve, adenosine triphosphate (ATP) levels, membrane potential (MP), and the expression of genes related to fatty acid biosynthesis in the cell membrane. In addition, the morphological changes in C. acnes by BSS were observed using transmission electron microscopy (TEM). Experimentally, we verified that BSS possessed significant antibacterial activity against C. acnes, with an MIC and MBC of 15.62 \u03bcg\/mL and 62.5 \u03bcg\/mL, respectively. The growth curve indicated that BSS at 2 MIC, MIC, 1\/2 MIC, and 1\/4 MIC concentrations inhibited the growth of C. acnes. TEM images demonstrated that BSS at an MIC concentration disrupted the morphological structure and cell membrane in C. acnes. Furthermore, the BSS at the 2 MIC, MIC, and 1\/2 MIC concentrations caused a decrease in the intracellular ATP levels and the depolarization of the cell membrane as well as BSS at an MIC concentration inhibited the expression of fatty acid biosynthesis-associated genes. In conclusion, BSS could exert good antimicrobial activity by interfering with cell membrane in C. acnes, which have the potential to be developed as a natural antiacne additive.<\/jats:p>","DOI":"10.3390\/microorganisms11122958","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T06:56:00Z","timestamp":1702277760000},"page":"2958","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antimicrobial Activity of Stilbenes from Bletilla striata against Cutibacterium acnes and Its Effect on Cell Membrane"],"prefix":"10.3390","volume":"11","author":[{"given":"Qian","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-4426","authenticated-orcid":false,"given":"Fu","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiji","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinmei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Arooj, A., Rehman, A.U., Iqbal, M., Naz, I., Alhodaib, A., and Ahmed, N. 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