{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:51:56Z","timestamp":1780084316669,"version":"3.54.0"},"reference-count":62,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grants-in-Aid for JSPS Fellows","award":["22F21389"],"award-info":[{"award-number":["22F21389"]}]},{"name":"Grants-in-Aid for JSPS Fellows","award":["B:20H03476"],"award-info":[{"award-number":["B:20H03476"]}]},{"name":"Ministry of Education, Culture, Science, Sports, and Technology (MEXT) of Japan, and by a Livestock Promotional Subsidy from the Japan Racing Association","award":["22F21389"],"award-info":[{"award-number":["22F21389"]}]},{"name":"Ministry of Education, Culture, Science, Sports, and Technology (MEXT) of Japan, and by a Livestock Promotional Subsidy from the Japan Racing Association","award":["B:20H03476"],"award-info":[{"award-number":["B:20H03476"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Transcriptional variation has been studied but post-transcriptional modification due to RNA editing has not been investigated in Plasmodium. We investigated developmental stage-specific RNA editing in selected genes in Plasmodium falciparum 3D7. We detected extensive amination- and deamination-type RNA editing at 8, 16, 24, 32, 40, and 46 h in tightly synchronized Plasmodium. Most of the editing events were observed in 8 and 16 h ring-stage parasites. Extensive A-to-G deamination-type editing was detected more during the 16 h ring stage (25%) than the 8 h ring stage (20%). Extensive U-to-C amination-type editing was detected more during the 16 h ring stage (31%) than the 8 h ring stage (22%). In 28S, rRNA editing converted the loop structure to the stem structure. The hemoglobin binding activity of PF3D7_0216900 was also altered due to RNA editing. Among the expressed 28S rRNA genes, PF3D7_0532000 and PF3D7_0726000 expression was higher. Increased amounts of the transcripts of these two genes were found, particularly PF3D7_0726000 in the ring stage and PF3D7_0532000 in the trophozoite and schizont stages. Adenosine deaminase (ADA) expression did not correlate with the editing level. This first experimental report of RNA editing will help to identify the editing machinery that might be useful for antimalarial drug discovery and malaria control.<\/jats:p>","DOI":"10.3390\/microorganisms12010137","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T05:47:21Z","timestamp":1704865641000},"page":"137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Detection of Developmental Asexual Stage-Specific RNA Editing Events in Plasmodium falciparum 3D7 Malaria Parasite"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-1198","authenticated-orcid":false,"given":"Md Thoufic Anam","family":"Azad","sequence":"first","affiliation":[{"name":"Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-onsen, Osaki, Miyagi 989-6711, Japan"},{"name":"Department of Veterinary and Animal Sciences, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Sugi","sequence":"additional","affiliation":[{"name":"Division of Collaboration and Education, International Institute for Zoonosis Control, Hokkaido University, Nishi10-Kita 20, Sapporo 001-0020, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umme","family":"Qulsum","sequence":"additional","affiliation":[{"name":"Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-onsen, Osaki, Miyagi 989-6711, Japan"},{"name":"Department of Botany, Faculty of Biological Sciences, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Kato","sequence":"additional","affiliation":[{"name":"Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-onsen, Osaki, Miyagi 989-6711, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2022). World Malaria Report 2022, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jmgm.2012.02.004","article-title":"The adenosine deaminases of Plasmodium vivax and Plasmodium falciparum exhibit surprising differences in ligand specificity","volume":"35","author":"Ivanov","year":"2012","journal-title":"J. Mol. Graph. Model."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1038\/s41467-022-33403-9","article-title":"A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin","volume":"13","author":"Qiu","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1101\/gr.129692.111","article-title":"Transcriptional variation in the malaria parasite Plasmodium falciparum","volume":"22","author":"Gupta","year":"2012","journal-title":"Genome Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Dave, B., Kanyal, A., Mamatharani, D.V., and Karmodiya, K. (2022). Pervasive sequence-level variation in the transcriptome of Plasmodium falciparum. NAR Genom. Bioinform., 4.","DOI":"10.1093\/nargab\/lqac036"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1212795","article-title":"RNA editing underlies temperature adaptation in K+ channels from polar octopuses","volume":"335","author":"Garrett","year":"2012","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cell.2017.03.025","article-title":"Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods","volume":"169","author":"Alon","year":"2017","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-biochem-060208-105251","article-title":"Funtions and regulation of RNA editing by ADAR deaminases","volume":"79","author":"Nishikura","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Niavarani, A., Currie, E., Reyal, Y., Anjos-Afonso, F., Horswell, S., Griessinger, E., Sardina, J.L., and Bonnet, D. (2015). APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120089"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41576-022-00459-8","article-title":"Functions and consequences of AID\/APOBEC-mediated DNA and RNA deamination","volume":"23","author":"Pecori","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1038\/s41467-022-30531-0","article-title":"Cellular and genetic drivers of RNA editing variation in the human brain","volume":"13","author":"Cuddleston","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1007\/s12035-016-0201-z","article-title":"The Good and the Bad of Glutamate Receptor RNA Editing","volume":"54","author":"Filippini","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1261\/rna.2114505","article-title":"Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencing","volume":"11","author":"Iwamoto","year":"2005","journal-title":"RNA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12374-018-0452-5","article-title":"Analysis of tissue-specific RNA editing events of genes involved in RNA editing in Arabidopsis thaliana","volume":"62","author":"Qulsum","year":"2019","journal-title":"J. Plant Biol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Okudaira, C., Sakari, M., and Tsukahara, T. (2021). Genome-wide identification of U-to-C RNA editing events for nuclear genes in Arabidopsis thaliana. Cells, 10.","DOI":"10.3390\/cells10030635"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9966","DOI":"10.1093\/nar\/gkac752","article-title":"Plant mitochondrial RNA editing factors can perform targeted C-to-U editing of nuclear transcripts in human cells","volume":"50","author":"Lesch","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.abb.2019.04.002","article-title":"Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine","volume":"667","author":"Jaruwat","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1038\/s41467-018-05652-0","article-title":"Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine","volume":"9","author":"Ross","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.protis.2016.06.003","article-title":"Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing, and Include Antisense Sequences","volume":"167","author":"Nisbet","year":"2016","journal-title":"Protist"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"eadg4725","DOI":"10.1126\/science.adg4725","article-title":"Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing","volume":"381","author":"Liu","year":"2023","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41586-021-04288-3","article-title":"Malaria protection due to sickle haemoglobin depends on parasite genotype","volume":"602","author":"Band","year":"2022","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12936-018-2392-4","article-title":"Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts","volume":"17","author":"Nonaka","year":"2018","journal-title":"Malar. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"102789","DOI":"10.1016\/j.parint.2023.102789","article-title":"Antiplasmodial and interferon-gamma-modulating activities of the aqueous extract of stone breaker (Phyllanthus niruri Linn.) in malaria infection","volume":"97","author":"Jeje","year":"2023","journal-title":"Parasitol. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncomms1324","article-title":"Predicting sites of ADAR editing in double-stranded RNA","volume":"2","author":"Eggington","year":"2011","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/s41596-022-00728-0","article-title":"I-TASSER-MTD: A deep-learning-based platform for multi-domain protein structure and function prediction","volume":"17","author":"Zhou","year":"2022","journal-title":"Nat. Protoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100014","DOI":"10.1016\/j.crmeth.2021.100014","article-title":"Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations","volume":"1","author":"Zheng","year":"2021","journal-title":"Cell Rep. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: Massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ge, S.X., Son, E.W., and Yao, R. (2018). iDEP: An integrated web application for differential expression and pathway analysis of RNA-Seq data. BMC Bioinform., 19.","DOI":"10.1186\/s12859-018-2486-6"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"19477","DOI":"10.1038\/s41598-019-55573-1","article-title":"Computational discovery of hidden breaks in 28S ribosomal RNAs across eukaryotes and consequences for RNA Integrity Numbers","volume":"9","author":"Natsidis","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1242\/jcs.111948","article-title":"Eukaryotic ribosome biogenesis at a glance","volume":"126","author":"Thomson","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.exppara.2013.07.025","article-title":"Secondary structure prediction for complete rDNA sequences (18S, 5.8S, and 28S rDNA) of Demodex folliculorum, and comparison of divergent domains structures across Acari","volume":"135","author":"Zhao","year":"2013","journal-title":"Exp. Parasitol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Bakhtiarizadeh, M.R., Salehi, A., and Rivera, R.M. (2018). Genome-wide identification and analysis of A-to-I RNA editing events in bovine by transcriptome sequencing. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193316"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/gt.2017.90","article-title":"Site-directed RNA editing by adenosine deaminase acting on RNA (ADAR1) for correction of the genetic code in gene therapy","volume":"24","author":"Azad","year":"2017","journal-title":"Gene Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/1566523218666181114122116","article-title":"Comparative activity of adenosine deaminase acting on RNA (ADARs) isoforms for correction of genetic code in gene therapy","volume":"19","author":"Azad","year":"2019","journal-title":"Curr. Gene Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41587-022-01225-1","article-title":"Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides","volume":"40","author":"Monian","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41587-021-01171-4","article-title":"Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs","volume":"40","author":"Katrekar","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Azad, M.T.A., Qulsum, U., and Tsukahara, T. (2023). Examination of factors affecting site-directed RNA editing by the MS2-ADAR1 deaminase system. Genes, 14.","DOI":"10.3390\/genes14081584"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Avram-Shperling, A., Kopel, E., Twersky, I., Gabay, O., Ben-David, A., Karako-Lampert, S., Rosenthal, J.J.C., Levanon, E.Y., Eisenberg, E., and Ben-Aroya, S. (2023). Identification of exceptionally potent adenosine deaminases RNA editors from high body temperature organisms. PLOS Genet., 19.","DOI":"10.1371\/journal.pgen.1010661"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1016\/j.cell.2023.05.004","article-title":"Temperature-dependent RNA editing in octopus extensively recodes the neural proteome","volume":"186","author":"Birk","year":"2023","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"144414","DOI":"10.1016\/j.gene.2020.144414","article-title":"Exploration of copy number variation in genes related to anti-malarial drug resistance in Plasmodium falciparum","volume":"736","author":"Qidwai","year":"2020","journal-title":"Gene"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/mmi.14632","article-title":"The contribution of extrachromosomal DNA to genome plasticity in malaria parasites","volume":"115","author":"Zhang","year":"2020","journal-title":"Mol. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13045-020-00945-8","article-title":"Principles and innovative technologies for decrypting noncoding RNAs: From discovery and functional prediction to clinical application","volume":"13","author":"Sun","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"22638","DOI":"10.1074\/jbc.M101234200","article-title":"Functional equivalence of structurally distinct ribosomes in the malaria parasite, Plasmodium berghei","volume":"276","author":"Ramesar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"eaao0665","DOI":"10.1126\/sciadv.aao0665","article-title":"Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression","volume":"4","author":"Parks","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1038\/ncomms6729","article-title":"An artificial PPR scaffold for programmable RNA recognition","volume":"5","author":"Coquille","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.1073\/pnas.1705780114","article-title":"Two interacting PPR proteins are major Arabidopsis editing factors in plastid and mitochondria","volume":"114","author":"Guillaumot","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8883","DOI":"10.1073\/pnas.1705815114","article-title":"Multiple PPR protein interactions are involved in the RNA editing system in Arabidopsis mitochondria and plastids","volume":"114","author":"Zhu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e57799","DOI":"10.7554\/eLife.57799","article-title":"Plasmodium falciparum translational machinery condones polyadenosine repeats","volume":"9","author":"Djuranovic","year":"2020","journal-title":"eLife"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ruchika, and Tsukahara, T (2021). The U-to-C RNA editing affects the mRNA stability of nuclear genes in Arabidopsis thaliana. Biochem. Biophys. Res. Commun., 571, 110\u2013117.","DOI":"10.1016\/j.bbrc.2021.06.098"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1073\/pnas.0711067105","article-title":"Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum","volume":"105","author":"Elliott","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Pishchany, G., and Skaar, E.P. (2012). Taste for Blood: Hemoglobin as a Nutrient Source for Pathogens. PLoS ONE, 8.","DOI":"10.1371\/journal.ppat.1002535"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s40588-021-00166-8","article-title":"Hemozoin: A complex molecule with complex activities","volume":"8","author":"Dalapati","year":"2021","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pt.2020.09.016","article-title":"Hemozoin in malarial complications: More questions than answers","volume":"37","author":"Pham","year":"2021","journal-title":"Trends Parasitol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Charnaud, S.C., Kumarasingha, R., Bullen, H.E., Crabb, B.S., and Gilson, P.R. (2018). Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export. PLoS ONE, 13.","DOI":"10.1101\/420034"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Rieder, L.E., A Savva, Y., A Reyna, M., Chang, Y.-J., Dorsky, J.S., Rezaei, A., and A Reenan, R. (2015). Dynamic response of RNA editing to temperature in Drosophila. BMC Biol., 13.","DOI":"10.1186\/s12915-014-0111-3"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1261\/rna.066522.118","article-title":"Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation","volume":"24","author":"Riemondy","year":"2018","journal-title":"RNA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13072-015-0029-1","article-title":"A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation and identifies H3K36me2 as a global mark of gene suppression","volume":"8","author":"Karmodiya","year":"2015","journal-title":"Epigenetics Chromatin"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/bfgp\/elz005","article-title":"The role of epigenetics and chromatin structure in transcriptional regulation in malaria parasites","volume":"18","author":"Abel","year":"2019","journal-title":"Brief. Funct. Genomics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.12573","article-title":"Translational regulation during stage transitions in malaria parasites","volume":"1342","author":"Cui","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rawat, M., Srivastava, A., Johri, S., Gupta, I., and Karmodiya, K. (2021). Single-Cell RNA sequencing reveals cellular heterogeneity and stage transition under temperature stress in synchronized Plasmodium falciparum cells. Microbiol. Spectr., 9.","DOI":"10.1128\/Spectrum.00008-21"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Xie, Y., Chan, P.-L., Kwan, H.-S., and Chang, J. (2023). The genome-wide characterization of alternative splicing and RNA editing in the development of Coprinopsis cinerea. J. Fungi, 9.","DOI":"10.3390\/jof9090915"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/1\/137\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:43:37Z","timestamp":1760103817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/1\/137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["microorganisms12010137"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms12010137","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]}}}