{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:12:57Z","timestamp":1790298777401,"version":"4.1.0"},"reference-count":76,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Defense Threat Reduction Agency","award":["HDTRA1-19-D-0007"],"award-info":[{"award-number":["HDTRA1-19-D-0007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>First recognized 15 years ago, Heartland virus disease (Heartland) is a tickborne infection contracted from the transmission of Heartland virus (HRTV) through tick bites from the lone star tick (Amblyomma americanum) and potentially other tick species. Heartland symptoms include a fever &lt;100.4 \u00b0F, lethargy, fatigue, headaches, myalgia, a loss of appetite, nausea, diarrhea, weight loss, arthralgia, leukopenia and thrombocytopenia. We reviewed the existing peer-reviewed literature for HRTV and Heartland to more completely characterize this rarely reported, recently discovered illness. The absence of ongoing serosurveys and targeted clinical and tickborne virus investigations specific to HRTV presence and Heartland likely contributes to infection underestimation. While HRTV transmission occurs in southern and midwestern states, the true range of this infection is likely larger than now understood. The disease\u2019s proliferation benefits from an expanded tick range due to rising climate temperatures favoring habitat expansion. We recommend HRTV disease be considered in the differential diagnosis for patients with a reported exposure to ticks in areas where HRTV has been previously identified. HRTV testing should be considered early for those matching the Heartland disease profile and nonresponsive to initial broad-spectrum antimicrobial treatment. Despite aggressive supportive therapy, patients deteriorating to sepsis early in the course of the disease have a very grim prognosis.<\/jats:p>","DOI":"10.3390\/microorganisms12020286","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:54:03Z","timestamp":1706518443000},"page":"286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Heartland Virus Disease\u2014An Underreported Emerging Infection"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-3246","authenticated-orcid":false,"given":"Zygmunt F.","family":"Dembek","sequence":"first","affiliation":[{"name":"Battelle Memorial Institute, Support to DTRA Technical Reachback, Columbus, OH 43201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Mothershead","sequence":"additional","affiliation":[{"name":"Applied Research Associates (ARA), Support to DTRA Technical Reachback, Albuquerque, NM 87110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-0542","authenticated-orcid":false,"given":"Christopher M.","family":"Cirimotich","sequence":"additional","affiliation":[{"name":"Battelle Memorial Institute, Support to DTRA Technical Reachback, Columbus, OH 43201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Wu","sequence":"additional","affiliation":[{"name":"Defense Threat Reduction Agency (DTRA), Fort Belvoir, VA 22060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","first-page":"256","article-title":"Heartland Virus: A New Virus Discovered in Missouri","volume":"113","author":"Esguerra","year":"2016","journal-title":"Mo. 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