{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:21:22Z","timestamp":1787678482429,"version":"build-2784847793"},"reference-count":51,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Direcci\u00f3n de Investigaci\u00f3n of the Universidad Peruana de Ciencias Aplicadas","award":["A-068\u20132020"],"award-info":[{"award-number":["A-068\u20132020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>(1) Background: Human fascioliasis is considered an endemic and hyper-endemic disease in the Peruvian Andean valleys. Our objective was to determine variations in the composition of the gut microbiota among children with Fasciola hepatica and children who do not have this parasitosis. (2) Method: A secondary analysis was performed using fecal samples stored in our biobank. The samples were collected as part of an epidemiological Fasciola hepatica cross-sectional study in children from 4 through 14 years old from a community in Cajamarca, Peru. (3) Results: In a comparison of the bacterial genera that make up the intestinal microbiota between the F. hepatica positive and negative groups, it was found that there are significant differences in the determination of Lactobacillus (p = 0.010, CI: 8.5\u201361.4), Bacteroides (p = 0.020, CI: 18.5\u201361.4), Clostridium (p &lt; 0.001, CI: 3.5\u201336.0), and Bifidobacterium (p = 0.018, CI: 1.1\u201328.3), with each of these genera being less frequent in children parasitized with F. hepatica. (4) Conclusions: These results show that F. hepatica may be associated with direct or indirect changes in the bacterial population of the intestinal microbiota, particularly affecting three bacterial genera.<\/jats:p>","DOI":"10.3390\/microorganisms12020371","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:47:45Z","timestamp":1707713265000},"page":"371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parasitosis by Fasciola hepatica and Variations in Gut Microbiota in School-Aged Children from Peru"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-8084","authenticated-orcid":false,"given":"Wilmer","family":"Silva-Caso","sequence":"first","affiliation":[{"name":"Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"},{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-8895","authenticated-orcid":false,"given":"Hugo","family":"Carrillo-Ng","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-3190","authenticated-orcid":false,"given":"Miguel Angel","family":"Aguilar-Luis","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"},{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yordi","family":"Tarazona-Castro","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-1741","authenticated-orcid":false,"given":"Luis J. Del","family":"Valle","sequence":"additional","affiliation":[{"name":"Barcelona Research Center for Multiscale Science and Engineering, Departament d\u2019Enginyeria Qu\u00edmica, EEBE, Universitat Polit\u00e8cnica de Catalunya (UPC), 08019 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Tinco-Valdez","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Palomares-Reyes","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Numan","family":"Urteaga","sequence":"additional","affiliation":[{"name":"Puesto de Salud Callancas, Direcci\u00f3n Regional de Salud Cajamarca (DIRESA), Cajamarca 60101, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Baz\u00e1n-Mayra","sequence":"additional","affiliation":[{"name":"Laboratorio Regional de Cajamarca, Direcci\u00f3n Regional de Salud de Cajamarca (DIRESA), Cajamarca 60101, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana del","family":"Valle-Mendoza","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"},{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/pim.12343","article-title":"A prospective view of animal and human Fasciolosis","volume":"38","author":"Cwiklinski","year":"2016","journal-title":"Parasite Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1017\/S0031182018000914","article-title":"Human fascioliasis infection sources, their diversity, incidence factors, analytical ethods and prevention measures","volume":"145","author":"Bargues","year":"2018","journal-title":"Parasitology"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nyindo, M., and Lukambagire, A.H. 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