{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:48:13Z","timestamp":1760143693605,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of University and Research","award":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"],"award-info":[{"award-number":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"]}]},{"name":"University of Turin","award":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"],"award-info":[{"award-number":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"]}]},{"name":"\u201cCassa di Risparmio\u201d of Turin Foundation","award":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"],"award-info":[{"award-number":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"]}]},{"name":"EU","award":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"],"award-info":[{"award-number":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"]}]},{"name":"Dipartimenti di Eccellenza 2023\u20132027","award":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"],"award-info":[{"award-number":["2017ALPCM","2022S3AZCC","2022N7EXJM","RILO2021","RILO2022","RILO2023","2021.1745","PE00000007","D13C22003520001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The rise of drug resistance to antivirals poses a significant global concern for public health; therefore, there is a pressing need to identify novel compounds that can effectively counteract strains resistant to current antiviral treatments. In light of this, researchers have been exploring new approaches, including the investigation of natural compounds as alternative sources for developing potent antiviral therapies. Thus, this work aimed to evaluate the antiviral properties of the organic-soluble fraction of a root exudate derived from the tomato plant Solanum lycopersicum in the context of herpesvirus infections. Our findings demonstrated that a root exudate from Solanum lycopersicum exhibits remarkable efficacy against prominent members of the family Herpesviridae, specifically herpes simplex virus type 1 (HSV-1) (EC50 25.57 \u00b5g\/mL, SI &gt; 15.64) and human cytomegalovirus (HCMV) (EC50 9.17 \u00b5g\/mL, SI 32.28) by inhibiting a molecular event during the herpesvirus replication phase. Moreover, the phytochemical fingerprint of the Solanum lycopersicum root exudate was characterized through mass spectrometry. Overall, these data have unveiled a novel natural product with antiherpetic activity, presenting a promising and valuable alternative to existing drugs.<\/jats:p>","DOI":"10.3390\/microorganisms12020373","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:47:45Z","timestamp":1707713265000},"page":"373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiherpetic Activity of a Root Exudate from Solanum lycopersicum"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-2479","authenticated-orcid":false,"given":"Greta","family":"Bajetto","sequence":"first","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"},{"name":"Center for Translational Research on Autoimmune and Allergic Disease (CAAD), 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-2750","authenticated-orcid":false,"given":"Davide","family":"Arnodo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Turin, 10125 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-0762","authenticated-orcid":false,"given":"Matteo","family":"Biolatti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Trifir\u00f2","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-6332","authenticated-orcid":false,"given":"Camilla","family":"Albano","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3815-2494","authenticated-orcid":false,"given":"Selina","family":"Pasquero","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6389-5129","authenticated-orcid":false,"given":"Francesca","family":"Gugliesi","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6945-5535","authenticated-orcid":false,"given":"Eva","family":"Campo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Forestry, and Food Sciences, University of Turin, 10095 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4016-227X","authenticated-orcid":false,"given":"Francesca","family":"Spyrakis","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9510-8783","authenticated-orcid":false,"given":"Cristina","family":"Prandi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Turin, 10125 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-5783","authenticated-orcid":false,"given":"Marco","family":"De Andrea","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"},{"name":"Center for Translational Research on Autoimmune and Allergic Disease (CAAD), 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-7906","authenticated-orcid":false,"given":"Valentina","family":"Dell\u2019Oste","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Visentin","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Forestry, and Food Sciences, University of Turin, 10095 Turin, 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(2020). Where Do We Stand after Decades of Studying Human Cytomegalovirus?. Microorganisms, 8.","DOI":"10.3390\/microorganisms8050685"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1542\/pir.30.4.119","article-title":"Herpes Simplex","volume":"30","author":"Chayavichitsilp","year":"2009","journal-title":"Pediatr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clp.2014.10.005","article-title":"Neonatal Herpes Simplex Virus Infection: Epidemiology and Treatment","volume":"42","author":"James","year":"2015","journal-title":"Clin. Perinatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11785","DOI":"10.3389\/ti.2023.11785","article-title":"New Treatment Options for Refractory\/Resistant CMV Infection","volume":"36","author":"Walti","year":"2023","journal-title":"Transpl. Int."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chen, S.-J., Wang, S.-C., and Chen, Y.-C. (2019). Antiviral Agents as Therapeutic Strategies Against Cytomegalovirus Infections. Viruses, 12.","DOI":"10.3390\/v12010021"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Piperi, E., Papadopoulou, E., Georgaki, M., Dovrat, S., Bar Illan, M., Nikitakis, N.G., and Yarom, N. (2023). Management of Oral Herpes Simplex Virus Infections: The Problem of Resistance. A Narrative Review. Oral Dis.","DOI":"10.1111\/odi.14635"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.2147\/IDR.S395203","article-title":"In-Silico Approaches for the Screening and Discovery of Broad-Spectrum Marine Natural Product Antiviral Agents against Coronaviruses","volume":"16","author":"Boswell","year":"2023","journal-title":"IDR"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Musarra-Pizzo, M., Pennisi, R., Ben-Amor, I., Mandalari, G., and Sciortino, M.T. (2021). Antiviral Activity Exerted by Natural Products against Human Viruses. Viruses, 13.","DOI":"10.3390\/v13050828"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/2225-4110.124335","article-title":"Antiviral Natural Products and Herbal Medicines","volume":"4","author":"Lin","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"723233","DOI":"10.3389\/fphar.2021.723233","article-title":"Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation","volume":"12","author":"Stan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_13","first-page":"1","article-title":"Antibacterial Effects of the Aqueous Extract of Lycopersicon Esculentum Mill Native in South Khorasan of Iran against Four Species Associated with Gastrointestinal Infections","volume":"7","author":"Shamshirgaran","year":"2020","journal-title":"J. Basic Res. Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1177\/153537020222701013","article-title":"Overview of Mechanisms of Action of Lycopene","volume":"227","author":"Heber","year":"2002","journal-title":"Exp. Biol. Med."},{"key":"ref_15","first-page":"1678","article-title":"Review on Factors Affecting the Quality and Antioxidant Properties of Tomatoes","volume":"16","author":"Tilahun","year":"2017","journal-title":"AJB"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kumar, M., Tomar, M., Bhuyan, D.J., Punia, S., Grasso, S., S\u00e1, A.G.A., Carciofi, B.A.M., Arrutia, F., Changan, S., and Singh, S. (2021). Tomato (Solanum lycopersicum L.) Seed: A Review on Bioactives and Biomedical Activities. Biomed. Pharmacother., 142.","DOI":"10.1016\/j.biopha.2021.112018"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/bbb\/zbac181","article-title":"Plant Specialized Metabolites in the Rhizosphere of Tomatoes: Secretion and Effects on Microorganisms","volume":"87","author":"Nakayasu","year":"2022","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1094\/MPMI-19-0250","article-title":"Organic Acids, Sugars, and l-Tryptophane in Exudates of Vegetables Growing on Stonewool and Their Effects on Activities of Rhizosphere Bacteria","volume":"19","author":"Kamilova","year":"2006","journal-title":"MPMI"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1094\/MPMI.1997.10.1.102","article-title":"Amino Acid Synthesis Is Necessary for Tomato Root Colonization by Pseudomonas Fluorescens Strain WCS365","volume":"10","author":"Simons","year":"1997","journal-title":"MPMI"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1016\/j.csbj.2020.11.025","article-title":"Genetic Factors Involved in Rhizosphere Colonization by Phytobeneficial Pseudomonas Spp","volume":"18","author":"Zboralski","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jfca.2003.10.003","article-title":"Investigation of the Antioxidant Properties of Tomatoes after Processing","volume":"17","author":"Sahlin","year":"2004","journal-title":"J. Food Compos. Anal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0094-0143(02)00020-4","article-title":"Tomato Products, Lycopene, and Prostate Cancer Risk","volume":"29","author":"Miller","year":"2002","journal-title":"Urol. Clin. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.food.102308.124120","article-title":"An Update on the Health Effects of Tomato Lycopene","volume":"1","author":"Story","year":"2010","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.antiviral.2018.11.011","article-title":"Tomatidine, a Novel Antiviral Compound towards Dengue Virus","volume":"161","author":"Troost","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1038\/s41598-020-63397-7","article-title":"Tomatidine, a Natural Steroidal Alkaloid Shows Antiviral Activity towards Chikungunya Virus in Vitro","volume":"10","author":"Troost","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0166-3542(85)90003-8","article-title":"The Inactivation of Herpes Simplex Virus by Some Solanaceae Glycoalkaloids","volume":"5","author":"Thorne","year":"1985","journal-title":"Antivir. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1111\/pce.14169","article-title":"Strigolactones Affect Phosphorus Acquisition Strategies in Tomato Plants","volume":"44","author":"Santoro","year":"2021","journal-title":"Plant Cell Environ."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Pasquero, S., Gugliesi, F., Biolatti, M., Dell\u2019Oste, V., Albano, C., Bajetto, G., Griffante, G., Trifir\u00f2, L., Brugo, B., and Raviola, S. (2023). Citrullination Profile Analysis Reveals Peptidylarginine Deaminase 3 as an HSV-1 Target to Dampen the Activity of Candidate Antiviral Restriction Factors. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011849"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Biolatti, M., Blangetti, M., D\u2019Arrigo, G., Spyrakis, F., Cappello, P., Albano, C., Ravanini, P., Landolfo, S., De Andrea, M., and Prandi, C. (2020). Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection. Microorganisms, 8.","DOI":"10.3390\/microorganisms8050703"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1021\/acsinfecdis.3c00219","article-title":"Strigolactones as Broad-Spectrum Antivirals against \u03b2-Coronaviruses through Targeting the Main Protease Mpro","volume":"7","author":"Biolatti","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1128\/JVI.01476-07","article-title":"The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G","volume":"82","author":"Sprague","year":"2008","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cnur.2020.05.004","article-title":"Herpes Simplex Virus: Epidemiology, Diagnosis, and Treatment","volume":"55","author":"Cole","year":"2020","journal-title":"Nurs. Clin. N. Am."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(00)04638-9","article-title":"Herpes Simplex Virus Infections","volume":"357","author":"Whitley","year":"2001","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12985-021-01581-5","article-title":"Inhibition of Herpes Simplex Virus-1 Infection by MBZM-N-IBT: In Silico and in Vitro Studies","volume":"18","author":"Kumar","year":"2021","journal-title":"Virol. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1128\/AAC.02311-13","article-title":"Metabolism of Cyclopropavir and Ganciclovir in Human Cytomegalovirus-Infected Cells","volume":"58","author":"Gentry","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1248\/bpb.23.363","article-title":"Anti-Herpes Virus Activity of Solanum Steroidal Glycosides","volume":"23","author":"Ikeda","year":"2000","journal-title":"Biol. Pharm. Bull."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1515\/znc-2009-11-1210","article-title":"Antiviral Activity of Solanum Paniculatum Extract and Constituents","volume":"64","author":"Valadares","year":"2009","journal-title":"Z. Naturforsch C J. Biosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jpha.2017.06.005","article-title":"Application of HPLC and ESI-MS Techniques in the Analysis of Phenolic Acids and Flavonoids from Green Leafy Vegetables (GLVs)","volume":"7","author":"Kumar","year":"2017","journal-title":"J. Pharm. Anal."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ali, M.Y., Sina, A.A.I., Khandker, S.S., Neesa, L., Tanvir, E.M., Kabir, A., Khalil, M.I., and Gan, S.H. (2020). Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review. Foods, 10.","DOI":"10.3390\/foods10010045"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1104\/pp.106.078428","article-title":"A Liquid Chromatography-Mass Spectrometry-Based Metabolome Database for Tomato","volume":"141","author":"Moco","year":"2006","journal-title":"Plant Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jnutbio.2014.12.001","article-title":"Effects of Dietary Virgin Olive Oil Polyphenols: Hydroxytyrosyl Acetate and 3, 4-Dihydroxyphenylglycol on DSS-Induced Acute Colitis in Mice","volume":"26","author":"Villegas","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/ptr.6084","article-title":"Inhibition of HSV-2 Infection by Pure Compounds from Thymus Capitatus Extract in Vitro","volume":"32","author":"Toujani","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1007\/s00705-017-3417-y","article-title":"Flavonoids: Promising Natural Compounds against Viral Infections","volume":"162","author":"Zakaryan","year":"2017","journal-title":"Arch. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/BF02978215","article-title":"Antiherpetic Activities of Flavonoids against Herpes Simplex Virus Type 1 (HSV-1) and Type 2 (HSV-2) in Vitro","volume":"28","author":"Lyu","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s12272-017-0898-x","article-title":"The Anti-HSV-1 Effect of Quercetin Is Dependent on the Suppression of TLR-3 in Raw 264.7 Cells","volume":"40","author":"Lee","year":"2017","journal-title":"Arch. Pharm. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Hung, P.-Y., Ho, B.-C., Lee, S.-Y., Chang, S.-Y., Kao, C.-L., Lee, S.-S., and Lee, C.-N. (2015). Houttuynia Cordata Targets the Beginning Stage of Herpes Simplex Virus Infection. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0115475"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Periferakis, A., Periferakis, A.-T., Troumpata, L., Periferakis, K., Scheau, A.-E., Savulescu-Fiedler, I., Caruntu, A., Badarau, I.A., Caruntu, C., and Scheau, C. (2023). Kaempferol: A Review of Current Evidence of Its Antiviral Potential. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216299"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.pharep.2017.07.002","article-title":"Beneficial Roles of Honey Polyphenols against Some Human Degenerative Diseases: A Review","volume":"69","author":"Hossen","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"ref_49","first-page":"739","article-title":"Tomato Lycopene and Its Role in Human Health and Chronic Diseases","volume":"163","author":"Agarwal","year":"2000","journal-title":"CMAJ"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jff.2018.01.003","article-title":"Bioactive Compounds of Tomato: Cancer Chemopreventive Effects and Influence on the Transcriptome in Hepatocytes","volume":"42","author":"Periago","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Imran, M., Ghorat, F., Ul-Haq, I., Ur-Rehman, H., Aslam, F., Heydari, M., Shariati, M.A., Okuskhanova, E., Yessimbekov, Z., and Thiruvengadam, M. (2020). Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders. Antioxidants, 9.","DOI":"10.3390\/antiox9080706"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"104966","DOI":"10.1016\/j.phrs.2020.104966","article-title":"Lycopene in Protection against Obesity and Diabetes: A Mechanistic Review","volume":"159","author":"Zhu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"104730","DOI":"10.1016\/j.phrs.2020.104730","article-title":"Protective Effects of Lycopene in Cancer, Cardiovascular, and Neurodegenerative Diseases: An Update on Epidemiological and Mechanistic Perspectives","volume":"155","author":"Saini","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.5650\/jos.ess20163","article-title":"Biological Activities of Z-Lycopenes Contained in Food","volume":"69","author":"Sakemi","year":"2020","journal-title":"J. Oleo Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Li, Q., Liu, F., and Wang, D. (2022). Lycoperoside H Protects against Diabetic Nephropathy via Alteration of Gut Microbiota and Inflammation. J. Biochem. Mol. Toxicol., 36.","DOI":"10.1002\/jbt.23216"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Thomas, E., Stewart, L.E., Darley, B.A., Pham, A.M., Esteban, I., and Panda, S.S. (2021). Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates. 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