{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:50:29Z","timestamp":1760143829632,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez","award":["HIM\/2017\/015.1337","HIM\/2018\/037.1512"],"award-info":[{"award-number":["HIM\/2017\/015.1337","HIM\/2018\/037.1512"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Zika virus (ZIKV) can cause neurological issues in infants. To provide protection, neutralizing antibodies should be transferred from the mother to the infant. We conducted a study at the Hospital General de Pochutla, Oaxaca, Mexico. Samples were collected from mothers (blood and breast milk) and infants (saliva and dried blood spots) within the first 12 postnatal hours (December 2017 to February 2018) and tested for ZIKV total and neutralizing antibodies as well as ZIKV-PCR. Microcephaly was evaluated according to INTERGROWTH-21st standards. Maternal IgG seroprevalence was 28.4% with 10.4% active infection, while infant IgG seroprevalence was 5.5% with 2.4% active infection. There were two cases of virolactia, and 6.3% of the infant saliva samples tested positive for ZIKV. Additionally, 18.3% of the infants were in a cephalic perimeter percentile lower than 10 and had an association between microcephaly and serology or a PCR between 8.6 and 60.9%. The infant blood samples had neutralizing antibodies, indicating intrauterine protection. Microcephaly was correlated with serology or PCR, but in our study population, non-ZIKV factors may be involved as well. Low ZIKV infection values in breast milk mean that breastfeeding is safe in most of the mothers and infants of the endemic area studied.<\/jats:p>","DOI":"10.3390\/microorganisms12030423","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T04:04:14Z","timestamp":1708401854000},"page":"423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intrauterine Transmission of Zika and Vertical Transfer of Neutralizing Antibodies Detected Immediately at Birth in Oaxaca, Mexico: An Analysis in the Context of Microcephaly"],"prefix":"10.3390","volume":"12","author":[{"given":"Alfredo","family":"Porras-Garc\u00eda","sequence":"first","affiliation":[{"name":"Unidad de Cuidados Intensivos Neonatales, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Villanueva-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Cuidados Intensivos Neonatales, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Arnaud-Rios","sequence":"additional","affiliation":[{"name":"Hospital General de Pochutla Oaxaca, San Pedro Pochutla 70900, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Garc\u00eda-Lemus","sequence":"additional","affiliation":[{"name":"Unidad de Cuidados Intensivos Neonatales, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"Castillo-Romero","sequence":"additional","affiliation":[{"name":"Unidad de Cuidados Intensivos Neonatales, Hospital Infantil de M\u00e9xico 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Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-9973","authenticated-orcid":false,"given":"Juan","family":"Xicothencatl-Cortes","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda Intestinal, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadnna","family":"Cruz-C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda Intestinal, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalia","family":"Lira-Carmona","sequence":"additional","affiliation":[{"name":"Unidad de Instigaci\u00f3n M\u00e9dica en Enfermedades Infecciosas y Parasitarias, Hospital de pediatr\u00eda Centro M\u00e9dico Nacional, Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Arellano-Galindo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Enfermedades Infecciosas, Laboratorio de Virolog\u00eda Cl\u00ednica y Experimental, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"},{"name":"Centro Interdisciplinario de Ciencias de la Salud, Departamento de Medicina, Unidad Milpa Alta, Instituto Polit\u00e9cnico Nacional, Mexico City 12000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S935","DOI":"10.1093\/infdis\/jix515","article-title":"Zika virus structure, maturation, and receptors","volume":"216","author":"Sirohi","year":"2017","journal-title":"J. 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