{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:04:40Z","timestamp":1789657480653,"version":"4.0.1"},"reference-count":55,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Quota Premiale Fondi FRA 2023","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"Quota Premiale Fondi FRA 2023","award":["P2022LPT3R"],"award-info":[{"award-number":["P2022LPT3R"]}]},{"name":"Next Generation EU","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"Next Generation EU","award":["P2022LPT3R"],"award-info":[{"award-number":["P2022LPT3R"]}]},{"name":"MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases","award":["P2022LPT3R"],"award-info":[{"award-number":["P2022LPT3R"]}]},{"name":"PRIN PNRR 2022","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"PRIN PNRR 2022","award":["P2022LPT3R"],"award-info":[{"award-number":["P2022LPT3R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Grape pomace is the main by-product of vine-winery chains. It requires adequate treatment and disposal but is also an economically underused source of bioactive plant secondary metabolites. This study aimed to investigate the antibacterial effects of polyphenolic extracts from Aglianico (Vitis vinifera L.) grape pomace. In particular, hydroethanolic extracts obtained via an ultrasonic-assisted extraction technique were selected for antimicrobial tests. The extracts were screened for their antibacterial effects against foodborne pathogens that were both Gram-positive, in the case of Staphylococcus aureus and Bacillus cereus, and Gram-negative, in the case of Escherichia coli and Salmonella enterica subsp. enterica serovar Typhimurium, showing variable bacteriostatic and bactericidal effects. In addition, our results demonstrated that the tested grape pomace extracts can reduce the inhibitory concentration of standard antibiotics. Interestingly, selected extracts inhibited biofilm development by S. aureus and B. cereus. Overall, these new insights into the antibacterial properties of grape pomace extracts may represent a relevant step in the design of novel therapeutic tools to tackle foodborne diseases, and in the management of resistant biofilm-related infections.<\/jats:p>","DOI":"10.3390\/microorganisms12030437","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T04:23:10Z","timestamp":1708489390000},"page":"437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Vine-Winery Byproducts as Precious Resource of Natural Antimicrobials: In Vitro Antibacterial and Antibiofilm Activity of Grape Pomace Extracts against Foodborne Pathogens"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-4085","authenticated-orcid":false,"given":"Daniela","family":"Sateriale","sequence":"first","affiliation":[{"name":"Department of Science and Technology, University of Sannio, via F. De Sanctis Snc, 82100 Benevento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0377-1714","authenticated-orcid":false,"given":"Giuseppina","family":"Forgione","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, University of Sannio, via F. De Sanctis Snc, 82100 Benevento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Di Rosario","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1704-6606","authenticated-orcid":false,"given":"Chiara","family":"Pagliuca","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-5085","authenticated-orcid":false,"given":"Roberta","family":"Colicchio","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"},{"name":"CEINGE-Biotecnologie Avanzate s.c.ar.l., Via G. Salvatore 486, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-3843","authenticated-orcid":false,"given":"Marina","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, University of Sannio, via F. De Sanctis Snc, 82100 Benevento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-5055","authenticated-orcid":false,"given":"Caterina","family":"Pagliarulo","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, University of Sannio, via F. De Sanctis Snc, 82100 Benevento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","unstructured":"(2021, March 23). Food and Agriculture Organization of the United Nations\u2014Statistics Division (FAOSTAT). 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