{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:24:59Z","timestamp":1778217899829,"version":"3.51.4"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Mycobacterium abscessus complex (MABC), a rapidly growing Mycobacterium, is one of the most common causes of non-tuberculous mycobacteria (NTM) infections in the United States of America, and it has been associated with a wide spectrum of infections in immunocompetent and immunosuppressed individuals. Eradicating MABC is very challenging, even with prolonged combination therapies. The management of MABC infections in solid organ transplant (SOT) patients is usually complex given their net state of immunosuppression, associated comorbidities, and potential drug\u2013drug interactions, among other things. In this manuscript, we discussed the antimicrobial management of pulmonary and extrapulmonary MABC infections. In addition, we reviewed promising novel therapies such as clofazimine, omadacycline, bedaquiline, and inhaled tigecycline that could join the existing antimicrobial armamentarium to fight this infection associated with significant morbidity and mortality. However, further studies are needed, especially among the immunocompromised host.<\/jats:p>","DOI":"10.3390\/microorganisms12030596","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T06:58:39Z","timestamp":1710745119000},"page":"596","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapy of Mycobacterium abscessus Infections in Solid Organ Transplant Patients"],"prefix":"10.3390","volume":"12","author":[{"given":"Lubna","family":"Osman","sequence":"first","affiliation":[{"name":"Infectious Diseases, Mount Sinai Medical Center, 4300 Alton Rd, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Lopez","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Mount Sinai Medical Center, 4300 Alton Rd, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-125X","authenticated-orcid":false,"given":"Yoichiro","family":"Natori","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Miami School of Medicine, 1120 NW 14th Street, Miami, FL 33019, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Anjan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Miami School of Medicine, 1120 NW 14th Street, Miami, FL 33019, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-9440","authenticated-orcid":false,"given":"Julia","family":"Bini Viotti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Miami School of Medicine, 1120 NW 14th Street, Miami, FL 33019, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Simkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Miami School of Medicine, 1120 NW 14th Street, Miami, FL 33019, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciaa241","article-title":"Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS\/ERS\/ESCMID\/IDSA Clinical Practice Guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin. 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