{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:05:08Z","timestamp":1760144708735,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>This research explores the association between ABO blood groups and susceptibility to SARS-CoV-2 infection, analyzing Convalescent COVID-19 plasma (CCP) donors (n = 500) and healthy whole blood donors (BDs) (n = 9678) during the pandemic (1 May 2020 to 30 April 2021). A comparison is made with pre-pandemic BDs (n = 11,892) from 1 May 2018 to 30 April 2019. Significant differences in blood group distribution are observed, with blood group A individuals being three times more likely to be CCP donors. Conversely, blood groups B, O, and AB are less associated with CCP donation. Notably, blood group O is more prevalent among regular BDs, suggesting potential resistance to SARS-CoV-2 infection. This study underscores variations in blood group distribution during the pandemic compared to pre-pandemic periods. The findings support previous research indicating a link between blood group antigens and viral susceptibility, including SARS-CoV-2. Understanding these associations has implications for public health strategies, with potential for predicting COVID-19 outcomes and transmission patterns. Further research is crucial to explore molecular and immunological mechanisms, providing valuable insights for targeted preventive strategies and personalized healthcare in managing the impact of COVID-19.<\/jats:p>","DOI":"10.3390\/microorganisms12050915","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:39:42Z","timestamp":1714649982000},"page":"915","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Blood Group Variations in COVID-19 Convalescent Plasma and Regular Blood Donors: A Comparative Analysis in the Serbian Population"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-4768","authenticated-orcid":false,"given":"Jasmina","family":"Gruji\u0107","sequence":"first","affiliation":[{"name":"Department of Transfusiology, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Blood Transfusion Institute of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Diagnostics and Laboratory Research Task Force, Balkan Association for Vector-Borne Diseases, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Budakov-Obradovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Transfusiology, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Blood Transfusion Institute of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Kla\u0161nja","sequence":"additional","affiliation":[{"name":"Department of Transfusiology, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Blood Transfusion Institute of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radovan","family":"Dini\u0107","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Department, Emergency Center, University Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-5479","authenticated-orcid":false,"given":"Vladimir","family":"Dolinaj","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Department of Anesthesia and Intensive Care, Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8660-730X","authenticated-orcid":false,"given":"Alejandro","family":"Cabezas-Cruz","sequence":"additional","affiliation":[{"name":"ANSES, INRAE, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, UMR BIPAR, Laboratoire de Sant\u00e9 Animale, F-94700 Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-6606","authenticated-orcid":false,"given":"Pavle","family":"Banovi\u0107","sequence":"additional","affiliation":[{"name":"Diagnostics and Laboratory Research Task Force, Balkan Association for Vector-Borne Diseases, 21000 Novi Sad, Serbia"},{"name":"Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Department of Microbiology with Parasitology and Immunology, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105798","DOI":"10.1016\/j.isci.2022.105798","article-title":"ABO Blood Group Antigens and Differential Glycan Expression: Perspective on the Evolution of Common Human Enzyme Deficiencies","volume":"26","author":"Jajosky","year":"2023","journal-title":"iScience"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/wsbm.1355","article-title":"Blood Type Biochemistry and Human Disease","volume":"8","author":"Ewald","year":"2016","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Abegaz, S.B. (2021). Human ABO Blood Groups and Their Associations with Different Diseases. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/6629060"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2149\/tmh.2014-25","article-title":"The Role of Carbohydrates in Infection Strategies of Enteric Pathogens","volume":"43","author":"Kato","year":"2015","journal-title":"Trop. Med. Health"},{"key":"ref_5","first-page":"e37415","article-title":"Assessment of Salivary ABO Blood Group Antigens and Secretor Status in Sriganganagar, Rajasthan: A Correlational Analysis of 300 Samples","volume":"15","author":"Rajawat","year":"2023","journal-title":"Cureus"},{"key":"ref_6","first-page":"1","article-title":"FUT2 Gene as a Genetic Susceptible Marker of Infectious Diseases: A Review","volume":"13","author":"Kaur","year":"2022","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/jgh.14766","article-title":"Association of FUT2 and ABO with Crohn\u2019s Disease in Koreans","volume":"35","author":"Ye","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1021\/acsinfecdis.0c00747","article-title":"COVID-19 in the Developing World: Is the Immune Response to \u03b1-Gal an Overlooked Factor Mitigating the Severity of Infection?","volume":"6","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.pt.2020.08.001","article-title":"\u03b1-Gal-Based Vaccines: Advances, Opportunities, and Perspectives","volume":"36","year":"2020","journal-title":"Trends Parasitol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1084\/jem.182.5.1345","article-title":"A Novel Mechanism of Retrovirus Inactivation in Human Serum Mediated by Anti-Alpha-Galactosyl Natural Antibody","volume":"182","author":"Rother","year":"1995","journal-title":"J. Exp. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e00027-20","DOI":"10.1128\/mBio.00027-20","article-title":"Heterosubtypic Protection Induced by a Live Attenuated Influenza Virus Vaccine Expressing Galactose-\u03b1-1,3-Galactose Epitopes in Infected Cells","volume":"11","author":"Yan","year":"2020","journal-title":"mBio"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1182\/blood.V99.7.2477","article-title":"Expression of ABO or Related Antigenic Carbohydrates on Viral Envelopes Leads to Neutralization in the Presence of Serum Containing Specific Natural Antibodies and Complement","volume":"99","author":"Preece","year":"2002","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"111411","DOI":"10.1016\/j.jclinane.2024.111411","article-title":"Convalescent Plasma: An Unexpected New Therapeutic Option for Critically Ill COVID-19 Patients Coming from the Past","volume":"94","author":"Franchini","year":"2024","journal-title":"J. Clin. Anesth."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"308","DOI":"10.7326\/M20-4511","article-title":"Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness","volume":"174","author":"Ray","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100785","DOI":"10.1016\/j.blre.2020.100785","article-title":"The Impact of ABO Blood Group on COVID-19 Infection Risk and Mortality: A Systematic Review and Meta-Analysis","volume":"48","author":"Liu","year":"2021","journal-title":"Blood Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1182\/blood.2022018903","article-title":"Blood Group A Enhances SARS-CoV-2 Infection","volume":"142","author":"Wu","year":"2023","journal-title":"Blood"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/joim.13588","article-title":"A Population-Based, Retrospective Cohort Study of the Association between ABO Blood Group and Risk of COVID-19","volume":"293","author":"Li","year":"2023","journal-title":"J. Intern. Med."},{"key":"ref_18","unstructured":"(2024, January 20). Pravilnik o Davaocima Krvi Ili Komponenata Krvi: 6\/2019-132. Available online: https:\/\/www.pravno-informacioni-sistem.rs\/SlGlasnikPortal\/eli\/rep\/sgrs\/ministarstva\/pravilnik\/2019\/6\/11."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gruji\u0107, J., Bujandri\u0107, N., Budakov-Obradovi\u0107, Z., Dolinaj, V., Bogdan, D., Savi\u0107, N., Cabezas-Cruz, A., Mijatovi\u0107, D., Simin, V., and An\u0111eli\u0107, N. (2021). Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19010042"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Banchelli, F., Negro, P., Guido, M., D\u2019Amico, R., Fittipaldo, V.A., Grima, P., and Zizza, A. (2022). The Role of ABO Blood Type in Patients with SARS-CoV-2 Infection: A Systematic Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11113029"},{"key":"ref_21","first-page":"1450","article-title":"ABO Blood Group and Susceptibility to Severe Acute Respiratory Syndrome","volume":"293","author":"Cheng","year":"2005","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103169","DOI":"10.1016\/j.transci.2021.103169","article-title":"Systematic Review and Meta-Analysis of the Susceptibility of ABO Blood Group to COVID-19 Infection","volume":"60","author":"Kabrah","year":"2021","journal-title":"Transfus. Apher. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/trf.16365","article-title":"The Impact of ABO Blood Groups on Clinical Outcomes and Susceptibility to COVID-19: A Retrospective Study in an Unselected Population","volume":"61","author":"Alduaij","year":"2021","journal-title":"Transfusion"},{"key":"ref_24","first-page":"ZC01","article-title":"Evaluation of the Secretor Status of ABO Blood Group Antigens in Saliva among Southern Rajasthan Population Using Absorption Inhibition Method","volume":"10","author":"Metgud","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1128\/CMR.00109-14","article-title":"Blood Groups in Infection and Host Susceptibility","volume":"28","author":"Cooling","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_26","first-page":"489","article-title":"Prevalence of ABO and RhD Blood Group Phenotypes in the Croatian Population and in Patients with Severe COVID-19 in Croatia","volume":"20","author":"Vuk","year":"2022","journal-title":"Blood Transfus."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1177\/2047487320922370","article-title":"ABO Blood Group Predisposes to COVID-19 Severity and Cardiovascular Diseases","volume":"27","author":"Dai","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Boukhari, R., Breiman, A., Jazat, J., Ruvo\u00ebn-Clouet, N., Martinez, S., Damais-Cepitelli, A., Le Niger, C., Devie-Hubert, I., Penasse, F., and Mauriere, D. (2022). ABO Blood Group Incompatibility Protects Against SARS-CoV-2 Transmission. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.799519"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Morales-N\u00fa\u00f1ez, J.J., Mu\u00f1oz-Valle, J.F., Torres-Hern\u00e1ndez, P.C., and Hern\u00e1ndez-Bello, J. (2021). Overview of Neutralizing Antibodies and Their Potential in COVID-19. Vaccines, 9.","DOI":"10.3390\/vaccines9121376"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/glycob\/cwn093","article-title":"Inhibition of the Interaction between the SARS-CoV Spike Protein and Its Cellular Receptor by Anti-Histo-Blood Group Antibodies","volume":"18","author":"Guillon","year":"2008","journal-title":"Glycobiology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijid.2020.12.025","article-title":"COVID-19 and Blood Groups: ABO Antibody Levels May Also Matter","volume":"104","author":"Deleers","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Matzhold, E.M., K\u00f6rm\u00f6czi, G.F., Banfi, C., Sch\u00f6nbacher, M., Drexler-Helmberg, C., Steinmetz, I., Berghold, A., Schlenke, P., Wagner, G.E., and Stoisser, A. (2022). Lower Levels of ABO Anti-A and Anti-B of IgM, IgG and IgA Isotypes in the Serum but Not the Saliva of COVID-19 Convalescents. J. Clin. Med., 11.","DOI":"10.3390\/jcm11154513"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1038\/emm.2016.164","article-title":"Effect of Blood Type on Anti-\u03b1-Gal Immunity and the Incidence of Infectious Diseases","volume":"49","author":"Alberdi","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1038\/s41598-023-30714-9","article-title":"ABO Blood Types and SARS-CoV-2 Infection Assessed Using Seroprevalence Data in a Large Population-Based Sample: The SAPRIS-SERO Multi-Cohort Study","volume":"13","author":"Esseddik","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1007\/s00277-020-04169-1","article-title":"Blood Type and Outcomes in Patients with COVID-19","volume":"99","author":"Latz","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"102571","DOI":"10.1016\/j.bcmd.2021.102571","article-title":"ABO Blood Groups, COVID-19 Infection and Mortality","volume":"89","author":"Lehrer","year":"2021","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1021\/acscentsci.7b00517","article-title":"Immunity to \u03b1-Gal: Toward a Single-Antigen Pan-Vaccine To Control Major Infectious Diseases","volume":"3","year":"2017","journal-title":"ACS Cent. Sci."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/5\/915\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:37:28Z","timestamp":1760107048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/5\/915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["microorganisms12050915"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms12050915","relation":{},"ISSN":["2076-2607"],"issn-type":[{"type":"electronic","value":"2076-2607"}],"subject":[],"published":{"date-parts":[[2024,4,30]]}}}