{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:40:30Z","timestamp":1791589230977,"version":"4.3.4"},"reference-count":56,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Slovak VEGA agency","award":["2\/0077\/23"],"award-info":[{"award-number":["2\/0077\/23"]}]},{"name":"Slovak VEGA agency","award":["APVV-17-0028"],"award-info":[{"award-number":["APVV-17-0028"]}]},{"name":"Slovak Research and Development Agency","award":["2\/0077\/23"],"award-info":[{"award-number":["2\/0077\/23"]}]},{"name":"Slovak Research and Development Agency","award":["APVV-17-0028"],"award-info":[{"award-number":["APVV-17-0028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Beneficial\/probiotic strains protect the host from pathogens by competitive displacement and production of antibacterial substances, i.e., bacteriocins. The antiparasitic potential of bacteriocins\/enterocins and their producing strains in experimental murine trichinellosis were tested as a new therapeutic strategy. Enterocin M and Durancin-like and their producers Enterococcus faecium CCM8558 and Enterococcus durans ED26E\/7 were administered daily to mice that were challenged with Trichinella spiralis. Our study confirmed the antiparasitic effect of enterocins\/enterococci, which reduced the number of adults in the intestine (Enterocin M\u201443.8%, E. faecium CCM8558\u201454.5%, Durancin-like\u201416.4%, E. durans ED26E\/7\u201435.7%), suppressed the Trichinella reproductive capacity ex vivo (Enterocin M\u201461%, E. faecium CCM8558\u201474%, Durancin-like\u201438%, E. durans ED26E\/7\u201466%), and reduced the number of muscle larvae (Enterocin M\u201439.6%, E. faecium CCM8558\u201455.7%, Durancin-like\u201415%, E. durans ED26E\/7\u201436.3%). The direct effect of enterocins on Trichinella fecundity was documented by an in vitro test in which Durancin-like showed a comparable reducing effect to Enterocin M (40\u201360%) in contrast to the ex vivo test. The reducing activity of T.spiralis infection induced by Enterocin M was comparable to its strain E. faecium CCM8558; Durancin-like showed lower antiparasitic activity than its producer E. durans ED26E\/7.<\/jats:p>","DOI":"10.3390\/microorganisms12050923","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:39:42Z","timestamp":1714649982000},"page":"923","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antiparasitic Activity of Enterocin M and Durancin-like from Beneficial Enterococci in Mice Experimentally Infected with Trichinella spiralis"],"prefix":"10.3390","volume":"12","author":[{"given":"Miroslava","family":"Petrov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Parasitology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-2992","authenticated-orcid":false,"given":"Zuzana","family":"Hurn\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-3816","authenticated-orcid":false,"given":"Andrea","family":"Laukov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, 040 01 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-6125","authenticated-orcid":false,"given":"Em\u00edlia","family":"Dvoro\u017e\u0148\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/CMR.00026-08","article-title":"Epidemiology, diagnosis, treatment, and control of trichinellosis","volume":"22","author":"Gottstein","year":"2009","journal-title":"Clin. 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