{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:07:43Z","timestamp":1792109263579,"version":"4.4.0"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China Medical University Hospital","award":["DMR-113-119"],"award-info":[{"award-number":["DMR-113-119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Anti-interferon (IFN)-\u03b3 autoantibodies are linked to varicella zoster virus (VZV) infection. Given the elevated risks of herpes zoster (HZ) in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKis), we aimed to examine the relationship between anti-IFN-\u03b3 autoantibodies with HZ development in JAKi-treated patients. Serum titers of anti-IFN-\u03b3 autoantibodies, plasma levels of IFN-\u03b3, monocyte chemoattractant protein-1 (MCP-1), and IFN-\u03b3-inducible protein-10 (IP-10) were measured by ELISA. Among the 66 enrolled RA patients, 24 developed new-onset HZ. Significantly lower MCP-1 levels were observed in patients with HZ compared to those without (median, 98.21 pg\/mL, interquartile range (IQR) 77.63\u2013150.30 pg\/mL versus 142.3 pg\/mL, IQR 106.7\u2013175.6 pg\/mL, p &lt; 0.05). There was no significant difference in anti-IFN-\u03b3 titers, IFN-\u03b3 levels, or IP-10 levels between patients with and without HZ. Three of 24 patients with HZ had severe HZ with multi-dermatomal involvement. Anti-IFN-\u03b3 titers were significantly higher in patients with severe HZ than in those with non-severe HZ (median 24.8 ng\/mL, IQR 21.0\u201338.2 ng\/mL versus 10.5 ng\/mL, IQR 9.9\u201315.0 ng\/mL, p &lt; 0.005). Our results suggest an association between reduced MCP-1 levels and HZ development in JAKi-treated RA patients. High-titer anti-IFN-\u03b3 autoantibodies may be related to severe HZ in these patients.<\/jats:p>","DOI":"10.3390\/microorganisms12050974","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T06:59:32Z","timestamp":1715756372000},"page":"974","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of the Reduced Levels of Monocyte Chemoattractant Protein-1 with Herpes Zoster in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors in a Single-Center Cohort"],"prefix":"10.3390","volume":"12","author":[{"given":"Po-Ku","family":"Chen","sequence":"first","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung 404, Taiwan"},{"name":"Translational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-3065","authenticated-orcid":false,"given":"Yi-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-4587","authenticated-orcid":false,"given":"Hsin-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 407, Taiwan"},{"name":"Big Data Center, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7059-4228","authenticated-orcid":false,"given":"Tsai-Ling","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan"},{"name":"Ph.D. Program in Translational Medicine, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsin","family":"Chang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung 404, Taiwan"},{"name":"Ph.D. Program in Translational Medicine, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Jieh","family":"Yeo","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-1423","authenticated-orcid":false,"given":"Der-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung 404, Taiwan"},{"name":"Translational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"Institute of Clinical Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","article-title":"Regulation of interferon-gamma during innate and adaptive immune responses","volume":"96","author":"Schoenborn","year":"2007","journal-title":"Adv. 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