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Probiotics, specifically bifidobacteria, have been associated with a reduction in the number of diarrhea episodes and their severity in babies. In this paper, we summarize the preclinical and clinical evidence of the efficacy of B. longum subsp. infantis IM1\u00ae against various gastrointestinal pathogens using in vitro models, animal models, and clinical studies carried out in our laboratory. The preclinical data demonstrate that IM1\u00ae effectively inhibits rotavirus replication (by up to 36.05%) in MA-104 and HT-29 cells and from infection (up to 48.50%) through the production of an 11-amino-acid peptide. IM1\u00ae displays the capability to displace pathogens from enterocytes, particularly Cronobacter sakazakii and Salmonella enterica, and to reduce the adhesion to the HT29 cells of C. sakazakii and Shigella sonnei. In animal models, the IM1\u00ae strain exhibits in vivo protection against rotavirus and improves the clinical symptomatology of bacterial gastroenteritis. A clinical study involving infants under 3 months of age revealed that IM1\u00ae reduced episodes of diarrhea, proving to be safe, well tolerated, and associated with a lower prevalence of constipation. B. infantis IM1\u00ae emerges as an effective probiotic, diminishing episodes of diarrhea caused by gastrointestinal pathogens.<\/jats:p>","DOI":"10.3390\/microorganisms12061183","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T11:58:58Z","timestamp":1718107138000},"page":"1183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Probiotic Bacterium with Activity against the Most Frequent Bacteria and Viruses Causing Pediatric Diarrhea: Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM1\u00ae)"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2172-7412","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Moreno-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Laboratorios Ordesa S.L., Parc Cient\u00edfic de Barcelona, C\/Baldiri Reixac 15-21, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Delgado","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Laboratorios Ordesa S.L., Parc Cient\u00edfic de Barcelona, C\/Baldiri Reixac 15-21, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Jim\u00e9nez","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorios Ordesa S.L., Parc Cient\u00edfic de Barcelona, C\/Baldiri Reixac 15-21, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1016\/j.vaccine.2023.06.064","article-title":"Systematic review of rotavirus vaccination cost-effectiveness in high income settings utilising dynamic transmission modelling techniques","volume":"41","author":"Jesudason","year":"2023","journal-title":"Vaccine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1053\/j.gastro.2009.02.076","article-title":"Rotaviruses: From Pathogenesis to Vaccination","volume":"136","author":"Greenberg","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_3","unstructured":"Knipe, D.M., and Howley, P.M. 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