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improving protection against infections. Here, the antagonistic effect of the 090104 strain on respiratory pathogens, including Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, was explored. In a series of in vitro studies, the capacity of C. pseudodiphtheriticum 090104, its bacterium-like particles, and its culture supernatants to coaggregate, inhibit the growth, and change the virulent phenotype of pathogenic bacteria was evaluated. The results showed that the 090104 strain was able to exert a bacteriostatic effect on K. pneumoniae and S. pneumoniae growth. In addition, C. pseudodiphtheriticum 090104 coaggregated, inhibited biofilm formation, and induced phenotypic changes in all the respiratory pathogens evaluated. In conclusion, this work demonstrated that, in addition to its beneficial effects exerted by host\u2013microbe interactions, C. pseudodiphtheriticum 090104 can enhance protection against respiratory pathogens through its microbe\u2013microbe interactions. The mechanisms involved in such interactions should be evaluated in future research.<\/jats:p>","DOI":"10.3390\/microorganisms12071295","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T05:03:07Z","timestamp":1719378187000},"page":"1295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antagonistic Effects of Corynebacterium\u00a0pseudodiphtheriticum 090104 on Respiratory Pathogens"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6242-7812","authenticated-orcid":false,"given":"Ramiro","family":"Ortiz Moyano","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), San Miguel de Tucum\u00e1n 4000, 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