{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:33:45Z","timestamp":1780756425525,"version":"3.54.1"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Corynebacterium jeikeium, a pleomorphic Gram-positive bacillus, is a common component of the cutaneous microbiota, usually considered as a contaminant, with little pathogenic potential. However, its role in various types of infections, such as bacteremia, sepsis, endocarditis (IE) and infection of prosthetic material is gradually being proven. Few cases of IE due to Corynebacterium jeikeium have been described in the literature. The aim of this article was to describe four cases of IE due to Corynebacterium jeikeium diagnosed in our hospital between May 2021 and April 2022, as well as to conduct a narrative review of the literature on this entity. After analysis, we highlight that 65.6% were men, 81.3% were valve or intravascular device carriers, and IE cases presented early, before one year after surgery. The most affected valve was the aortic valve (68.8%), followed by the mitral valve (21.1%). Valve replacement was performed in 65.6% of cases, and the most commonly used antibiotic was vancomycin (68.8%) at a dose of 15 mg\/kg\/12 h. With respect to prognosis, the overall mortality rate was 21.9%. The comparative results between our series and the literature review were similar except for a higher mortality rate (50%) and the use of dalbavancin in the treatment. We go on to review previously reported cases, along with four cases described in our hospital, of C. jeikeium endocarditis and will discuss various aspects of C. jeikeium infection, focusing on microbiology, pathophysiology, and treatment.<\/jats:p>","DOI":"10.3390\/microorganisms12071337","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T03:38:27Z","timestamp":1719805107000},"page":"1337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Infective Endocarditis Due to Corynebacterium jeikeium: Four Case Reports and Narrative Review of the Literature"],"prefix":"10.3390","volume":"12","author":[{"given":"Daniel","family":"Arn\u00e9s-Garc\u00eda","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lucena-Torres","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-6596","authenticated-orcid":false,"given":"Antonio","family":"Bustos-Merlo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rosales-Castillo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-5728","authenticated-orcid":false,"given":"Carmen","family":"Hidalgo-Tenorio","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Virgen de las Nieves, Instituto de Investigaci\u00f3n Biosanitario de Granada (IBS-Granada), 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1128\/CMR.10.1.125","article-title":"Clinical microbiology of coryneform bacteria","volume":"10","author":"Funke","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1128\/jcm.26.9.1878-1880.1988","article-title":"Skin colonization by Corynebacterium groups D2 and JK in hospitalized patients","volume":"26","author":"Soriano","year":"1988","journal-title":"J. Clin. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10096-019-03698-6","article-title":"From contamination to infective endocarditis-a population-based retrospective study of Corynebacterium isolated from blood cultures","volume":"39","author":"Rasmussen","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.3201\/eid2712.210473","article-title":"Clinical Characteristics of Corynebacterium Bacteremia Caused by Different Species, Japan, 2014\u20132020","volume":"27","author":"Yamamuro","year":"2021","journal-title":"Emerg. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/CRD.0000000000000355","article-title":"Corynebacterium Jeikeium Endocarditis: A Review of the Literature","volume":"29","author":"Gupta","year":"2021","journal-title":"Cardiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10096-006-0145-8","article-title":"Corynebacterium jeikeium endocarditis: A systematic overview spanning four decades","volume":"25","author":"Mookadam","year":"2006","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1128\/JB.187.13.4671-4682.2005","article-title":"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora","volume":"187","author":"Tauch","year":"2005","journal-title":"J. Bacteriol."},{"key":"ref_8","first-page":"151","article-title":"Corynebacterium jeikeium prosthetic joint infection: Case report and literature review","volume":"37","author":"Tleyjeh","year":"2005","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.arbres.2017.06.015","article-title":"Empyema necessitatis caused by Corynebacterium jeikeium: 19th century questions, 21st century answers","volume":"54","author":"Molina","year":"2018","journal-title":"Arch. Bronconeumol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/BF01964264","article-title":"An investigation of nosocomial infection with Corynebacterium jeikeium in surgical patients using a ribosomal RNA gene probe","volume":"9","author":"Pitcher","year":"1990","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_11","first-page":"123","article-title":"Biofilm Formation and Antimicrobial Susceptibility of Non-Diphtheria Corynebacterium Strains Isolated from Blood Cultures: First Report from Turkey","volume":"36","author":"Ozdemir","year":"2021","journal-title":"Medeni. Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.21037\/jtd.2017.09.69","article-title":"Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: A powerful tool for identification of Corynebacterium species","volume":"9","author":"Bao","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Burban, A., S\u0142upik, D., Reda, A., Szczerba, E., Grabowski, M., and Ko\u0142odzi\u0144ska, A. (2024). Novel Diagnostic Methods for Infective Endocarditis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021245"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jiac.2021.01.005","article-title":"Corynebacterium jeikeium-induced infective endocarditis and perivalvular abscess diagnosed by 16S ribosomal RNA sequence analysis: A case report","volume":"27","author":"Imoto","year":"2021","journal-title":"J. Infect. Chemother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0732-8893(97)00193-4","article-title":"Prospective study of catalase-positive coryneform organisms in clinical specimens: Identification, clinical relevance, and antibiotic susceptibility","volume":"30","author":"Lagrou","year":"1998","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0732-8893(93)90065-F","article-title":"Identification of clinical isolates of nondiphtherial Corynebacterium species and their antibiotic susceptibility patterns","volume":"17","author":"Williams","year":"1993","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/AAC.39.1.208","article-title":"Antimicrobial susceptibilities of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents","volume":"39","author":"Soriano","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1007\/BF01967505","article-title":"In vitro susceptibility of Corynebacterium group D2 and Corynebacterium jeikeium to twelve antibiotics","volume":"9","author":"Philippon","year":"1990","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/jac\/dkg129","article-title":"Activity of the oxazolidinones AZD2563 and linezolid against Corynebacterium jeikeium and other Corynebacterium spp.","volume":"51","author":"Johnson","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1128\/AAC.47.1.337-341.2003","article-title":"In vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 Corynebacterium clinical isolates","volume":"47","author":"Goldstein","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ijantimicag.2008.11.001","article-title":"In vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus Corynebacterium","volume":"33","author":"Adames","year":"2009","journal-title":"Int. J. Antimicrob. Agents."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/jac\/dkr513","article-title":"Activity of daptomycin and three comparator agents against non-diphtheriae Corynebacterium isolates of clinical interest","volume":"67","author":"Navas","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/jac\/dkh143","article-title":"Daptomycin activity and spectrum: A worldwide sample of 6737 clinical Gram-positive organisms","volume":"54","author":"Streit","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e02052-20","DOI":"10.1128\/JCM.02052-20","article-title":"Evaluating the Rapid Emergence of Daptomycin Resistance in Corynebacterium: A Multicenter Study","volume":"59","author":"Mitchell","year":"2021","journal-title":"J. Clin. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1128\/JCM.00457-09","article-title":"Life-threatening infection caused by daptomycin-resistant Corynebacterium jeikeium in a neutropenic patient","volume":"47","author":"Schoen","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1179\/joc.2001.13.3.244","article-title":"In vitro evaluation of BI 397, a novel glycopeptide antimicrobial agent","volume":"13","author":"Jones","year":"2001","journal-title":"J. Chemother."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Di Pilato, V., Ceccherini, F., Sennati, S., D\u2019Agostino, F., Arena, F., D\u2019Atanasio, N., Di Giorgio, F.P., Tongiani, S., Pallecchi, L., and Rossolini, G.M. (2020). In vitro time-kill kinetics of dalbavancin against Staphylococcus spp. biofilms over prolonged exposure times. Diagn. Microbiol. Infect. Dis., 96.","DOI":"10.1016\/j.diagmicrobio.2019.114901"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.diagmicrobio.2017.09.015","article-title":"Dalbavancin is active in vitro against biofilms formed by dalbavancin-susceptible enterococci","volume":"90","author":"Neudorfer","year":"2018","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"106918","DOI":"10.1016\/j.ijantimicag.2023.106918","article-title":"EN-DALBACEN 2.0 Cohort: Real-life study of dalbavancin as sequential\/consolidation therapy in patients with infective endocarditis due to Gram-positive cocci","volume":"62","author":"Loeches","year":"2023","journal-title":"Int. J. Antimicrob. Agents."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0163-4453(88)92047-6","article-title":"Corynebacterium group JK endocarditis after dental extraction under antibiotic cover","volume":"17","author":"Etienne","year":"1988","journal-title":"J. Infect."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0732-8893(89)90025-4","article-title":"Corynebacterium jeikeium (group JK diphtheroids) endocarditis: A report of five cases","volume":"12","author":"Vanbosterhaut","year":"1989","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_33","first-page":"236","article-title":"Native valve endocarditis due to Corynebacterium group JK","volume":"37","author":"Moffie","year":"1990","journal-title":"Neth. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/archderm.1991.01680060147033","article-title":"Palpable purpura associated with Corynebacterium jeikeium endocarditis","volume":"127","author":"Spach","year":"1991","journal-title":"Arch. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1097\/00007890-199206000-00037","article-title":"Aortic valve endocarditis in a liver transplant recipient-successful management by aortic valve replacement","volume":"53","author":"David","year":"1992","journal-title":"Transplantation"},{"key":"ref_36","first-page":"177","article-title":"Corynebacterium group JK endocarditis in a haemodialysis patient","volume":"8","author":"Costa","year":"1993","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/1069-417X(94)90009-4","article-title":"Prosthetic valve endocarditis due to Corynebacterium jeikeium","volume":"13","author":"Steele","year":"1994","journal-title":"Antimicrob. Infect. Dis. Newsl."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"E120","DOI":"10.1086\/319592","article-title":"Corynebacterium jeikeium native valve endocarditis following femoral access for coronary angiography","volume":"32","author":"Ross","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3201\/eid0801.010151","article-title":"Nosocomial endocarditis caused by Corynebacterium amycolatum and other nondiphtheriae corynebacteria","volume":"8","author":"Knox","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"ref_40","first-page":"302","article-title":"Endocarditis due to Corynebacterium jeikeium in a patient with acute myelogenous leukaemia","volume":"9","author":"Asimakopoulos","year":"2006","journal-title":"Haema"},{"key":"ref_41","first-page":"406","article-title":"Corynebacterium jeikeium native valve endocarditis","volume":"96","author":"Marques","year":"2007","journal-title":"Clin. Res. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1099\/jmm.0.023283-0","article-title":"Corynebacterium jeikeium pacemaker infection associated with antineutrophil cytoplasmic antibodies: A single positive blood culture could be sufficient for diagnosis","volume":"60","author":"Bechara","year":"2011","journal-title":"J. Med. Microbiol."},{"key":"ref_43","first-page":"729","article-title":"Treatment with daptomycin for Corynebacterium Jeikeium left-sided prosthetic valve endocarditis","volume":"78","author":"Lappa","year":"2012","journal-title":"Minerva Anestesiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"B107","DOI":"10.1053\/j.ajkd.2014.01.372","article-title":"Corynebacterium jeikeium endocarditis in a hemodialysis patient with an arterio venous fistula requiring surgical intervention","volume":"63","author":"Syed","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e00610","DOI":"10.1016\/j.idcr.2019.e00610","article-title":"A case of recurrent Corynebacterium jeikeium endocarditis: Unanswered questions for the treatment of chronic endovascular infections","volume":"18","author":"Clarke","year":"2019","journal-title":"IDCases"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s13730-020-00458-w","article-title":"Incidental detection of Corynebacterium jeikeium endocarditis via regular blood examination in an afebrile hemodialysis patient","volume":"9","author":"Oshiro","year":"2020","journal-title":"CEN Case Rep."},{"key":"ref_47","first-page":"1337","article-title":"Corynebacterium jeikeium native valve infective endocarditis case report: A confirmed microbiological and pathological diagnosis from heart valvular tissue","volume":"4","author":"Dowling","year":"2020","journal-title":"Eur. Heart J. Case Rep."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/7\/1337\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:08:03Z","timestamp":1760108883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/7\/1337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,29]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["microorganisms12071337"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms12071337","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,29]]}}}