{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:35:54Z","timestamp":1782167754794,"version":"3.54.5"},"reference-count":73,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNRS","award":["n\u25e611-BTBR-0003"],"award-info":[{"award-number":["n\u25e611-BTBR-0003"]}]},{"name":"CNRS","award":["ANR-15-CE09-0002"],"award-info":[{"award-number":["ANR-15-CE09-0002"]}]},{"name":"CNRS","award":["ANR-17-ASTR-0018INNOVANTIBIO"],"award-info":[{"award-number":["ANR-17-ASTR-0018INNOVANTIBIO"]}]},{"name":"University Paris-Saclay","award":["n\u25e611-BTBR-0003"],"award-info":[{"award-number":["n\u25e611-BTBR-0003"]}]},{"name":"University Paris-Saclay","award":["ANR-15-CE09-0002"],"award-info":[{"award-number":["ANR-15-CE09-0002"]}]},{"name":"University Paris-Saclay","award":["ANR-17-ASTR-0018INNOVANTIBIO"],"award-info":[{"award-number":["ANR-17-ASTR-0018INNOVANTIBIO"]}]},{"name":"ANR BioSound-IR","award":["n\u25e611-BTBR-0003"],"award-info":[{"award-number":["n\u25e611-BTBR-0003"]}]},{"name":"ANR BioSound-IR","award":["ANR-15-CE09-0002"],"award-info":[{"award-number":["ANR-15-CE09-0002"]}]},{"name":"ANR BioSound-IR","award":["ANR-17-ASTR-0018INNOVANTIBIO"],"award-info":[{"award-number":["ANR-17-ASTR-0018INNOVANTIBIO"]}]},{"name":"\u201cDirection G\u00e9n\u00e9rale des Arm\u00e9es\u201d (DGA)","award":["n\u25e611-BTBR-0003"],"award-info":[{"award-number":["n\u25e611-BTBR-0003"]}]},{"name":"\u201cDirection G\u00e9n\u00e9rale des Arm\u00e9es\u201d (DGA)","award":["ANR-15-CE09-0002"],"award-info":[{"award-number":["ANR-15-CE09-0002"]}]},{"name":"\u201cDirection G\u00e9n\u00e9rale des Arm\u00e9es\u201d (DGA)","award":["ANR-17-ASTR-0018INNOVANTIBIO"],"award-info":[{"award-number":["ANR-17-ASTR-0018INNOVANTIBIO"]}]},{"name":"\u201cl\u2019Agence de l\u2019Innovationde D\u00e9fense\u201d (AID)","award":["n\u25e611-BTBR-0003"],"award-info":[{"award-number":["n\u25e611-BTBR-0003"]}]},{"name":"\u201cl\u2019Agence de l\u2019Innovationde D\u00e9fense\u201d (AID)","award":["ANR-15-CE09-0002"],"award-info":[{"award-number":["ANR-15-CE09-0002"]}]},{"name":"\u201cl\u2019Agence de l\u2019Innovationde D\u00e9fense\u201d (AID)","award":["ANR-17-ASTR-0018INNOVANTIBIO"],"award-info":[{"award-number":["ANR-17-ASTR-0018INNOVANTIBIO"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Since nitrogen limitation is known to be an important trigger of triacylglycerol (TAG) accumulation in most microorganisms, we first assessed the global lipid content of 21 strains derived from Streptomyces coelicolor M145 deleted for genes involved in nitrogen metabolism. Seven of these strains deleted for genes encoding proteins involved in polyamine (GlnA2\/SCO2241, GlnA3\/SCO6962, GlnA4\/SCO1613), or protein (Pup\/SCO1646) degradation, in the regulation of nitrogen metabolism (GlnE\/SCO2234 and GlnK\/SCO5584), or the global regulator DasR\/SCO5231 that controls negatively the degradation of N-acetylglucosamine, a constituent of peptidoglycan, had a higher TAG content than the original strain, whereas five of these strains (except the glnA2 and pup mutants) had a lower cardiolipin (CL) content. The production of the blue polyketide actinorhodin (ACT) was totally abolished in the dasR mutant in both Pi conditions, whereas the deletion of pup, glnA2, glnA3, and glnA4 was correlated with a significant increase in total ACT production, but mainly in Pi limitation. Unexpectedly, ACT production was strongly reduced in the glnA3 mutant in Pi proficiency. Altogether, our data suggest that high TAG and ACT biosynthesis and low CL biosynthesis might all contribute to the lowering of oxidative stress resulting from nitrogen limitation or from other causes.<\/jats:p>","DOI":"10.3390\/microorganisms12081560","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:25:23Z","timestamp":1722353123000},"page":"1560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of the Deletion of Genes of the Nitrogen Metabolism on Triacylglycerol, Cardiolipin and Actinorhodin Biosynthesis in Streptomyces coelicolor"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7236-2292","authenticated-orcid":false,"given":"Sonia","family":"Abreu","sequence":"first","affiliation":[{"name":"Lip (Sys)2 (Lipides Syst\u00e8mes Analytiques et Biologiques), UFR Pharmacie-B\u00e2timent Henri Moissan, CNRS, CEA, Universit\u00e9 Paris-Saclay, 17 Avenue des Sciences, 91400 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4127-3884","authenticated-orcid":false,"given":"Clara","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), Department of Microbiology, Group \u201cEnergetic Metabolism of Streptomyces\u201d, CNRS, CEA, Universit\u00e9 Paris-Saclay, 1 Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"David","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), Department of Microbiology, Group \u201cEnergetic Metabolism of Streptomyces\u201d, CNRS, CEA, Universit\u00e9 Paris-Saclay, 1 Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chaminade","sequence":"additional","affiliation":[{"name":"Lip (Sys)2 (Lipides Syst\u00e8mes Analytiques et Biologiques), UFR Pharmacie-B\u00e2timent Henri Moissan, CNRS, CEA, Universit\u00e9 Paris-Saclay, 17 Avenue des Sciences, 91400 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Joelle","family":"Virolle","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), Department of Microbiology, Group \u201cEnergetic Metabolism of Streptomyces\u201d, CNRS, CEA, Universit\u00e9 Paris-Saclay, 1 Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1128\/JB.00591-15","article-title":"The Absence of Pupylation (Prokaryotic Ubiquitin-Like Protein Modification) Affects Morphological and Physiological Differentiation in Streptomyces coelicolor","volume":"197","author":"Boubakri","year":"2015","journal-title":"J. Bacteriol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1128\/JB.00302-15","article-title":"Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor","volume":"197","author":"Compton","year":"2015","journal-title":"J. Bacteriol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Krysenko, S., Okoniewski, N., Nentwich, M., Matthews, A., Bauerle, M., Zinser, A., Busche, T., Kulik, A., Gursch, S., and Kemeny, A. (2022). A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism in Streptomyces coelicolor. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073752"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Krysenko, S., Okoniewski, N., Kulik, A., Matthews, A., Grimpo, J., Wohlleben, W., and Bera, A. (2017). Gamma-Glutamylpolyamine Synthetase GlnA3 Is Involved in the First Step of Polyamine Degradation Pathway in Streptomyces coelicolor M145. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.00726"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/mBio.00326-19","article-title":"Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145","volume":"10","author":"Krysenko","year":"2019","journal-title":"Mbio"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gevrekci, A.O. (2017). The roles of polyamines in microorganisms. World J. Microbiol. Biotechnol., 33.","DOI":"10.1007\/s11274-017-2370-y"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Krysenko, S., and Wohlleben, W. (2022). Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity. Med. Sci., 10.","DOI":"10.3390\/medsci10030040"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/embor.2008.83","article-title":"Feast or famine: The global regulator DasR links nutrient stress to antibiotic production by Streptomyces","volume":"9","author":"Rigali","year":"2008","journal-title":"EMBO Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1365-2958.2006.05319.x","article-title":"The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development","volume":"61","author":"Rigali","year":"2006","journal-title":"Mol. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1365-2958.2009.07020.x","article-title":"The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control","volume":"75","author":"Nothaft","year":"2010","journal-title":"Mol. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1128\/JB.06370-11","article-title":"Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in control of development and antibiotic production","volume":"194","author":"Swiatek","year":"2012","journal-title":"J. Bacteriol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.1038\/s41598-019-45164-5","article-title":"Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria","volume":"9","author":"Santucci","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15811","DOI":"10.1074\/jbc.M111.334052","article-title":"Three acyltransferases and nitrogen-responsive regulator are implicated in nitrogen starvation-induced triacylglycerol accumulation in Chlamydomonas","volume":"287","author":"Boyle","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.funbio.2017.07.001","article-title":"Nitrogen-starvation triggers cellular accumulation of triacylglycerol in Metarhizium robertsii","volume":"122","author":"Chen","year":"2018","journal-title":"Fungal. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/mmi.13564","article-title":"The pleiotropic transcriptional regulator NlpR contributes to the modulation of nitrogen metabolism, lipogenesis and triacylglycerol accumulation in oleaginous rhodococci","volume":"103","author":"Hernandez","year":"2017","journal-title":"Mol. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1128\/AEM.68.9.4240-4246.2002","article-title":"A stationary-phase acyl-coenzyme A synthetase of Streptomyces coelicolor A3(2) is necessary for the normal onset of antibiotic production","volume":"68","author":"Banchio","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.chembiol.2012.06.013","article-title":"Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism","volume":"19","author":"Craney","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41587-019-0335-4","article-title":"Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces","volume":"38","author":"Wang","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"David, M., Lejeune, C., Abreu, S., Thibessard, A., Leblond, P., Chaminade, P., and Virolle, M.J. (2020). Negative Correlation between Lipid Content and Antibiotic Activity in Streptomyces: General Rule and Exceptions. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060280"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Dulermo, T., Lejeune, C., Aybeke, E., Abreu, S., Bleton, J., David, M., Deniset-Besseau, A., Chaminade, P., Thibessard, A., and Leblond, P. (2023). Genome Analysis of a Variant of Streptomyces coelicolor M145 with High Lipid Content and Poor Ability to Synthetize Antibiotics. Microorganisms, 11.","DOI":"10.3390\/microorganisms11061470"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8492","DOI":"10.1038\/s41598-020-65087-w","article-title":"Expression of genes of the Pho regulon is altered in Streptomyces coelicolor","volume":"10","author":"Henry","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Virolle, M.J. (2020). A Challenging View: Antibiotics Play a Role in the Regulation of the Energetic Metabolism of the Producing Bacteria. Antibiotics, 9.","DOI":"10.3390\/antibiotics9020083"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/417141a","article-title":"Hopwood DA. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)","volume":"417","author":"Bentley","year":"2002","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1177\/0003702817709459","article-title":"Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) for Rapid Determination of Microbial Cell Lipid Content: Correlation with Gas Chromatography-Mass Spectrometry (GC-MS)","volume":"71","author":"Rebois","year":"2017","journal-title":"Appl. Spectrosc."},{"key":"ref_25","unstructured":"Kieser, T., Bibb, M.J., Buttner, M.J., Chater, K.F., and Hopwood, D.A. (2000). Practical Streptomyces Genetics, John Innes Foundation."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.chroma.2017.07.063","article-title":"Optimization of normal phase chromatographic conditions for lipid analysis and comparison of associated detection techniques","volume":"1514","author":"Abreu","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lejeune, C., Abreu, S., Chaminade, P., Dulermo, T., David, M., Werten, S., and Virolle, M.J. (2021). Impact of Phosphate Availability on Membrane Lipid Content of the Model Strains, Streptomyces lividans and Streptomyces coelicolor. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.623919"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000516644","article-title":"Poly-and Monoamine Metabolism in Streptomyces coelicolor: The New Role of Glutamine Synthetase-Like Enzymes in the Survival under Environmental Stress","volume":"31","author":"Krysenko","year":"2021","journal-title":"Microb. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/mBio.00066-18","article-title":"Ethanolamine Utilization in Bacteria","volume":"9","author":"Kaval","year":"2018","journal-title":"Mbio"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biochi.2017.05.008","article-title":"Knowns and unknowns of membrane lipid synthesis in streptomycetes","volume":"141","author":"Guan","year":"2017","journal-title":"Biochimie"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sandoval-Calderon, M., Nguyen, D.D., Kapono, C.A., Herron, P., Dorrestein, P.C., and Sohlenkamp, C. (2015). Plasticity of Streptomyces coelicolor Membrane Composition Under Different Growth Conditions and During Development. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01465"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/femsre\/fuv008","article-title":"Bacterial membrane lipids: Diversity in structures and pathways","volume":"40","author":"Sohlenkamp","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JB.00685-17","article-title":"GntR Family Regulator DasR Controls Acetate Assimilation by Directly Repressing the acsA Gene in Saccharopolyspora erythraea","volume":"200","author":"You","year":"2018","journal-title":"J. Bacteriol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/mmi.12818","article-title":"Three genes encoding citrate synthases in Saccharopolyspora erythraea are regulated by the global nutrient-sensing regulators, G.l.n.R, DasR and CRP","volume":"94","author":"Liao","year":"2014","journal-title":"Mol. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Sato, R., Ara, S., Yamazaki, H., Ishiya, K., Aburatani, S., and Takaku, H. (2021). Citrate-Mediated Acyl-CoA Synthesis Is Required for the Promotion of Growth and Triacylglycerol Production in Oleaginous Yeast Lipomyces starkeyi. Microorganisms, 9.","DOI":"10.3390\/microorganisms9081693"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1758-2229.2012.00354.x","article-title":"Unsuspected control of siderophore production by N-acetylglucosamine in streptomycetes","volume":"4","author":"Craig","year":"2012","journal-title":"Environ. Microbiol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1042\/bj20031945","article-title":"Iron-regulatory proteins DmdR1 and DmdR2 of Streptomyces coelicolor form two different DNA-protein complexes with iron boxes","volume":"380","author":"Flores","year":"2004","journal-title":"Biochem. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1742-4658.2004.04509.x","article-title":"Functional analysis of two divalent metal-dependent regulatory genes dmdR1 and dmdR2 in Streptomyces coelicolor and proteome changes in deletion mutants","volume":"272","author":"Flores","year":"2005","journal-title":"FEBS J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1574-6968.2006.00362.x","article-title":"Identification of genes involved in siderophore transport in Streptomyces coelicolor A3(2)","volume":"262","author":"Bunet","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.tim.2021.12.014","article-title":"New views on PII signaling: From nitrogen sensing to global metabolic control","volume":"30","author":"Forchhammer","year":"2022","journal-title":"Trends Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Selim, K.A., and Alva, V. (2024). PII-like signaling proteins: A new paradigm in orchestrating cellular homeostasis. Curr. Opin. Microbiol., 79.","DOI":"10.1016\/j.mib.2024.102453"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"12979","DOI":"10.1021\/bi701062t","article-title":"Escherichia coli PII signal transduction protein controlling nitrogen assimilation acts as a sensor of adenylate energy charge in Vitro","volume":"46","author":"Jiang","year":"2007","journal-title":"Biochemistry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.bpj.2017.04.012","article-title":"GlnK Facilitates the Dynamic Regulation of Bacterial Nitrogen Assimilation","volume":"112","author":"Gosztolai","year":"2017","journal-title":"Biophys. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1099\/00221287-145-9-2313","article-title":"Nitrogen metabolism in Streptomyces coelicolor A3(2): Modification of glutamine synthetase I by an adenylyltransferase","volume":"145","author":"Fink","year":"1999","journal-title":"Microbiology"},{"key":"ref_45","first-page":"139","article-title":"Nitrogen metabolism in Streptomyces coelicolor: Transcriptional and post-translational regulation","volume":"12","author":"Reuther","year":"2007","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-2958.2002.03149.x","article-title":"The GlnD and GlnK homologues of Streptomyces coelicolor A3(2) are functionally dissimilar to their nitrogen regulatory system counterparts from enteric bacteria","volume":"46","author":"Hesketh","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00203-018-1603-2","article-title":"Fatty acid biosynthesis is enhanced in Escherichia coli strains with deletion in genes encoding the PII signaling proteins","volume":"201","author":"Rodrigues","year":"2019","journal-title":"Arch. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10811-020-02316-9","article-title":"Nitrogen starvation\u2013induced oxidative stress relieves PII-mediated inhibition of acetyl-CoA carboxylase (ACCase) activity and signals enhanced lipid synthesis in Synechococcus PCC 7942","volume":"33","author":"Verma","year":"2021","journal-title":"J. Appl. Phycol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e61148","DOI":"10.7554\/eLife.61148","article-title":"Ammonium Transporters: A molecular dual carriageway","volume":"9","author":"Allen","year":"2020","journal-title":"eLife"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s00253-018-09600-2","article-title":"Regulation of the phosphate metabolism in Streptomyces genus: Impact on the secondary metabolites","volume":"103","author":"Barreiro","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/synbio1030015","article-title":"Impact of Nitrogen-Containing Compounds on Secondary Metabolism in Streptomyces spp.\u2014A Source of Metabolic Engineering Strategies","volume":"1","author":"Krysenko","year":"2023","journal-title":"Synbio"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Pai, H., Liu, Y., Zhang, C., Su, J., and Lu, W. (2024). Effects of the pleiotropic regulator DasR on lincomycin production in Streptomyces lincolnensis. Appl. Microbiol. Biotechnol., 108.","DOI":"10.1007\/s00253-024-13201-7"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s10295-016-1845-4","article-title":"DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis","volume":"43","author":"Zhang","year":"2016","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10215","DOI":"10.1007\/s00253-015-6892-7","article-title":"DasR is a pleiotropic regulator required for antibiotic production, pigment biosynthesis, and morphological development in Saccharopolyspora erythraea","volume":"99","author":"Liao","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Swiatek-Polatynska, M.A., Bucca, G., Laing, E., Gubbens, J., Titgemeyer, F., Smith, C.P., Rigali, S., and van Wezel, G.P. (2015). Genome-wide analysis of in Vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122479"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"30246","DOI":"10.1074\/jbc.M113.490425","article-title":"Remodeling of membrane lipids in iron-starved Chlamydomonas","volume":"288","author":"Urzica","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Devadasu, E., and Subramanyam, R. (2021). Enhanced Lipid Production in Chlamydomonas reinhardtii Caused by Severe Iron Deficiency. Front. Plant. Sci., 12.","DOI":"10.3389\/fpls.2021.615577"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1021\/bi00173a020","article-title":"Translocation of metal phosphate via the phosphate inorganic transport system of Escherichia coli","volume":"33","author":"Abee","year":"1994","journal-title":"Biochemistry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11010-017-3039-4","article-title":"Cardiolipin deficiency causes triacylglycerol accumulation in Saccharomyces cerevisiae","volume":"434","author":"Yadav","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"52873","DOI":"10.1074\/jbc.M308366200","article-title":"Cardiolipin stabilizes respiratory chain supercomplexes","volume":"278","author":"Pfeiffer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-5793(02)03292-1","article-title":"Cardiolipin: A proton trap for oxidative phosphorylation","volume":"528","author":"Haines","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"42612","DOI":"10.1074\/jbc.M402545200","article-title":"Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependent","volume":"279","author":"Gohil","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"17383","DOI":"10.1074\/jbc.M109.006072","article-title":"A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria","volume":"284","author":"Geiger","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1128\/mr.44.2.230-251.1980","article-title":"Control of antibiotic biosynthesis","volume":"44","author":"Martin","year":"1980","journal-title":"Microbiol. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41598-017-00259-9","article-title":"Strong antibiotic production is correlated with highly active oxidative metabolism in Streptomyces coelicolor M145","volume":"7","author":"Esnault","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lejeune, C., Sago, L., Cornu, D., Redeker, V., and Virolle, M.J. (2022). A Proteomic Analysis Indicates That Oxidative Stress Is the Common Feature Triggering Antibiotic Production in Streptomyces coelicolor and in the pptA Mutant of Streptomyces lividans. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.813993"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1021\/acs.jproteome.7b00163","article-title":"Quantitative Proteomics Analysis Confirmed Oxidative Metabolism Predominates in Streptomyces coelicolor versus Glycolytic Metabolism in Streptomyces lividans","volume":"16","author":"Henry","year":"2017","journal-title":"J. Proteome. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhang, Y.M., Chen, H., He, C.L., and Wang, Q. (2013). Nitrogen starvation induced oxidative stress in an oil-producing green alga Chlorella sorokiniana C3. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069225"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Yilancioglu, K., Cokol, M., Pastirmaci, I., Erman, B., and Cetiner, S. (2014). Oxidative stress is a mediator for increased lipid accumulation in a newly isolated Dunaliella salina strain. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091957"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"102974","DOI":"10.1016\/j.algal.2023.102974","article-title":"Nitrogen limitation and hydrogen peroxide act synergistically to enhance lipids accumulation via ROS\/Ca2+ dependent mechanism in Chlorella sorokiniana","volume":"70","author":"Liufu","year":"2023","journal-title":"Algal. Research."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0378-4274(95)03532-X","article-title":"Toxicity of iron and hydrogen peroxide: The Fenton reaction","volume":"82\u201383","author":"Winterbourn","year":"1995","journal-title":"Toxicol Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1073\/pnas.2627990100","article-title":"Polyamines protect Escherichia coli cells from the toxic effect of oxygen","volume":"100","author":"Chattopadhyay","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00726-007-0513-4","article-title":"Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide","volume":"33","author":"Rider","year":"2007","journal-title":"Amino Acids"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/8\/1560\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:26:31Z","timestamp":1760109991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/8\/1560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":73,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["microorganisms12081560"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms12081560","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]}}}