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This study investigated the feasibility of cultivating the dinoflagellate Durusdinium glynnii in aquaculture wastewater from shrimp rearing in a synbiotic system (AWW-SS), with different dilutions of f\/2 medium (FM). Interestingly, D. glynnii demonstrated enhanced growth in all AWW\u2013SS treatments compared to the control (FM). The highest growth rates were achieved at AWW-SS:FM dilutions of 75:25 and 50:50. The removal of total nitrogen and total phosphorus reached 50.1 and 71.7%, respectively, of the crude AWW\u2013SS. Biomass extracts of D. glynnii grown with AWW\u2013SS were able to inhibit the growth of the bacteria Vibrio parahaemolyticus (inhibition zone of 10.0 \u00b1 1.7 mm) and V. vulnificus (inhibition zone of 11.7 \u00b1 1.5 mm). The presented results demonstrate that the dinoflagellate D. glynnii is a potential candidate for the development of circularity for sustainable aquaculture production, particularly by producing anti\u2013Vibrio compounds at a near-zero cost.<\/jats:p>","DOI":"10.3390\/microorganisms12081598","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:07:59Z","timestamp":1722931679000},"page":"1598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Holistic Approach to Producing Anti-Vibrio Metabolites by an Endosymbiotic Dinoflagellate Using Wastewater from Shrimp Rearing"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-1869","authenticated-orcid":false,"given":"Carlos Yure B.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Live Food Production, Department of Fisheries and Aquaculture, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil"},{"name":"Laboratory of Phycology, Department of Botany, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5614-0454","authenticated-orcid":false,"given":"J\u00e9ssika L.","family":"Abreu","sequence":"additional","affiliation":[{"name":"Laboratory of Live Food Production, Department of Fisheries and Aquaculture, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-6041","authenticated-orcid":false,"given":"Barbara C.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Live Food Production, Department of Fisheries and Aquaculture, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-4008","authenticated-orcid":false,"given":"Deyvid Willame S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Live Food Production, Department of Fisheries and Aquaculture, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Rodrigues","family":"de Sena","sequence":"additional","affiliation":[{"name":"Laboratory of Live Food Production, Department of Fisheries and Aquaculture, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-7166","authenticated-orcid":false,"given":"Weverson Ailton","family":"da Silva","sequence":"additional","affiliation":[{"name":"Fishery Resources and Engineering Postgraduate Program, State University of West Paran\u00e1, Toledo 85903-000, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-2368","authenticated-orcid":false,"given":"Evando S.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Research Group on Electrospinning and Nanotechnology Applications, Department of Materials Science, Federal University of San Francisco Valley, Juazeiro 48902-300, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo R.","family":"R\u00f6rig","sequence":"additional","affiliation":[{"name":"Laboratory of Phycology, Department of Botany, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-1643","authenticated-orcid":false,"given":"Gisely Karla","family":"de Almeida Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Aquatic Animal Health, Department of Fisheries and Aquaculture, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzianny Maria B. 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