{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:59:43Z","timestamp":1790819983100,"version":"4.1.0"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TDR, the Special Programme for Research and Training in Tropical Diseases co-sponsored by UNICEF, the UN Development Programme, the World Bank, and the WHO","award":["P22-00735"],"award-info":[{"award-number":["P22-00735"]}]},{"name":"TDR, the Special Programme for Research and Training in Tropical Diseases co-sponsored by UNICEF, the UN Development Programme, the World Bank, and the WHO","award":["307014\/2022-3"],"award-info":[{"award-number":["307014\/2022-3"]}]},{"name":"TDR, the Special Programme for Research and Training in Tropical Diseases co-sponsored by UNICEF, the UN Development Programme, the World Bank, and the WHO","award":["2023\/01758-6"],"award-info":[{"award-number":["2023\/01758-6"]}]},{"name":"the CNPq Research Productivity Grant","award":["P22-00735"],"award-info":[{"award-number":["P22-00735"]}]},{"name":"the CNPq Research Productivity Grant","award":["307014\/2022-3"],"award-info":[{"award-number":["307014\/2022-3"]}]},{"name":"the CNPq Research Productivity Grant","award":["2023\/01758-6"],"award-info":[{"award-number":["2023\/01758-6"]}]},{"name":"the S\u00e3o Paulo State Research Support Foundation (FAPESP)","award":["P22-00735"],"award-info":[{"award-number":["P22-00735"]}]},{"name":"the S\u00e3o Paulo State Research Support Foundation (FAPESP)","award":["307014\/2022-3"],"award-info":[{"award-number":["307014\/2022-3"]}]},{"name":"the S\u00e3o Paulo State Research Support Foundation (FAPESP)","award":["2023\/01758-6"],"award-info":[{"award-number":["2023\/01758-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Migration, a multifaceted phenomenon, has a significant impact on health. Migrants perform similar movement patterns within their country of origin, in transit, and in the country of destination, thus making it difficult to monitor TB treatment throughout the journey. The objective was to compare the effectiveness of different treatment modalities in adherence to the short-term regimen for LTBI (3HP) among international migrants and refugees. This is a quasi-experimental study conducted in Manaus-AM. The study population was made up of international migrants. The certification and monitoring of medication intake employed three strategies: self-administration (SA), directly observed conventional therapy (DOT), and Video Telemonitoring System for Tuberculosis Treatment (VDOT). The VDOT group and SA group exhibited the lowest rate of treatment dropout or interruption at 16.1%, followed by the DOT group at 23.1%. The results suggest that the most effective strategy for ensuring adherence among migrants and refugees was VDOT (OR_adj 0.26; CI 0.7\u20130.94), suggesting that migrants may be more likely to adhere to and complete their treatment. The results show that relying on different treatment strategies, adapted to the individuals\u2019 needs and risk factors, is a viable and effective way of providing person-centered TB care.<\/jats:p>","DOI":"10.3390\/microorganisms12081629","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T06:25:24Z","timestamp":1723271124000},"page":"1629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adherence to Short-Duration Treatment (3HP) for Latent Tuberculosis among International Migrants in Manaus, Amazonas: Evaluation of the Efficacy of Different Treatment Modalities"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-0047","authenticated-orcid":false,"given":"Yan Mathias","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Sao Paulo, Brazil"},{"name":"Brazilian Tuberculosis Research Network (REDE-TB), Rio de Janeiro 21941-904, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4163-8719","authenticated-orcid":false,"given":"Tha\u00eds Zamboni","family":"Berra","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Sao Paulo, Brazil"},{"name":"Brazilian Tuberculosis Research Network (REDE-TB), Rio de Janeiro 21941-904, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-8927","authenticated-orcid":false,"given":"Sonia Vivian de","family":"Jezus","sequence":"additional","affiliation":[{"name":"Sinop Campus, Federal University of Mato Grosso (UFMT), Sinop 78550-728, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia Maria Silva","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Brazilian Tuberculosis Research Network (REDE-TB), Rio de Janeiro 21941-904, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-5773","authenticated-orcid":false,"given":"Jair dos Santos","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"State Tuberculosis Control Program of Amazonas, Manaus 69093-018, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Bezerra de Oliveira de","family":"Assis","sequence":"additional","affiliation":[{"name":"State Tuberculosis Control Program of Amazonas, Manaus 69093-018, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvis","family":"Canelonez","sequence":"additional","affiliation":[{"name":"State Tuberculosis Control Program of Amazonas, Manaus 69093-018, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Souza","family":"Sacramento","sequence":"additional","affiliation":[{"name":"Municipal Tuberculosis Control Program, Manaus 69049-110, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-0057","authenticated-orcid":false,"given":"Freddy","family":"Perez","sequence":"additional","affiliation":[{"name":"Communicable Diseases Prevention, Control, and Elimination and Environmental Determinants of Health Department, Pan American Health Organization, Washington, DC 20037, USA"},{"name":"Department of Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-3355","authenticated-orcid":false,"given":"Ethel Leonor Noia","family":"Maciel","sequence":"additional","affiliation":[{"name":"Ministry of Health, Secretariat for Health Surveillance and the Environment, Bras\u00edlia 70058-900, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-8714","authenticated-orcid":false,"given":"Ricardo Alexandre","family":"Arc\u00eancio","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-902, Sao Paulo, Brazil"},{"name":"Brazilian Tuberculosis Research Network (REDE-TB), Rio de Janeiro 21941-904, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2020). 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