{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:08:44Z","timestamp":1792188524949,"version":"4.4.0"},"reference-count":44,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Sepsis is among the most frequent diagnoses on admission to the intensive care unit (ICU). A systemic inflammatory response, activated by uncontrolled infection, fosters hypoperfusion and multiorgan failure and often leads to septic shock and mortality. These infections arise from a specific anatomic source, and how the infection foci influence the outcomes is unknown. All patients admitted to the ICU of Hospital de Vila Franca de Xira, between 1 January 2017 and 31 June 2023, were screened for sepsis and categorized according to their infection foci. During the study period, 1296 patients (32.2%) had sepsis on admission. Their mean age was 67.5 \u00b1 15.3 and 58.1% were male; 73.0% had community-acquired infections. The lung was the main focus of infection. Septic shock was present in 37.9% of the patients and was associated with hospital mortality. Severe imbalances were noted in its incidence, and there was lower mortality in lung infections. The hospital-acquired infections had a slightly higher mortality but, after adjustment, this difference was non-significant. Patients with secondary bacteremia had a worse prognosis (one-year adjusted hazard ratio of 1.36, 95% confidence interval 1.06\u20131.74, p = 0.015), especially those with an isolated non-fermenting Gram-negative infection. Lung, skin, and skin structure infections and peritonitis had a worse prognosis, whilst urinary, biliary tract, and other intra-abdominal infections had a better one-year outcome.<\/jats:p>","DOI":"10.3390\/microorganisms12081705","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T03:43:28Z","timestamp":1724039008000},"page":"1705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Infectious Foci, Comorbidities and Its Influence on the Outcomes of Septic Critically Ill Patients"],"prefix":"10.3390","volume":"12","author":[{"given":"Ana Maria","family":"Oliveira","sequence":"first","affiliation":[{"name":"Unidade Cuidados Intensivos, Unidade Local de Sa\u00fade Estu\u00e1rio do Tejo, 2600-009 Vila Franca de Xira, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-0668","authenticated-orcid":false,"given":"Andr\u00e9","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Unidade Cuidados Intensivos, Unidade Local de Sa\u00fade Estu\u00e1rio do Tejo, 2600-009 Vila Franca de Xira, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Vidal","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-3777","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Gon\u00e7alves-Pereira","sequence":"additional","affiliation":[{"name":"Unidade Cuidados Intensivos, Unidade Local de Sa\u00fade Estu\u00e1rio do Tejo, 2600-009 Vila Franca de Xira, Portugal"},{"name":"Grupo de Investiga\u00e7\u00e3o e Desenvolvimento em Infe\u00e7\u00e3o e S\u00e9psis, Cl\u00ednica Universit\u00e1ria de Medicina Intensiva, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/1469-0691.12738","article-title":"Impact of Infection on Admission and of the Process of Care on Mortality of Patients Admitted to the Intensive Care Unit: The INFAUCI Study","volume":"20","author":"Pereira","year":"2014","journal-title":"Clin. 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