{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:49:05Z","timestamp":1791568145506,"version":"4.3.4"},"reference-count":157,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Parvovirus B19 (B19V) is a human pathogen belonging to the Parvoviridae family. It is widely diffused in the population and responsible for a wide range of diseases, diverse in pathogenetic mechanisms, clinical course, and severity. B19V infects and replicates in erythroid progenitor cells (EPCs) in the bone marrow leading to their apoptosis. Moreover, it can also infect, in an abortive manner, a wide set of different cell types, normally non-permissive, and modify their normal physiology. Differences in the characteristics of virus\u2013cell interaction may translate into different pathogenetic mechanisms and clinical outcomes. Joint involvement is a typical manifestation of B19V infection in adults. Moreover, several reports suggest, that B19V could be involved in the pathogenesis of some autoimmune rheumatologic diseases such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic sclerosis (SSc), systemic lupus erythematosus (SLE), or vasculitis. This review provides basic information on the B19 virus, highlights characteristics of viral infection in permissive and non-permissive systems, and focuses on recent findings concerning the pathogenic role of B19V in rheumatologic diseases.<\/jats:p>","DOI":"10.3390\/microorganisms12081708","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T05:19:36Z","timestamp":1724044776000},"page":"1708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Parvovirus B19 in Rheumatic Diseases"],"prefix":"10.3390","volume":"12","author":[{"given":"Rosaria","family":"Arvia","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-4565","authenticated-orcid":false,"given":"Maria A.","family":"Stincarelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Manaresi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-6341","authenticated-orcid":false,"given":"Giorgio","family":"Gallinella","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy"},{"name":"S. Orsola-Malpighi Hospital\u2014Microbiology, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Zakrzewska","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1099\/jgv.0.001212","article-title":"ICTV Virus Taxonomy Profile: Parvoviridae","volume":"100","author":"Cotmore","year":"2019","journal-title":"J. Gen. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1128\/CMR.00040-16","article-title":"Human Parvoviruses","volume":"30","author":"Qiu","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100007","DOI":"10.1016\/j.amolm.2023.100007","article-title":"Parvovirus B19: Insights and implication for pathogenesis, prevention and therapy","volume":"1","author":"Zakrzewska","year":"2023","journal-title":"Asp. Mol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJMra030840","article-title":"Parvovirus B19","volume":"350","author":"Young","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coviro.2017.10.003","article-title":"Parvovirus B19 infection in pregnancy-awareness and opportunities","volume":"27","author":"Bonvicini","year":"2017","journal-title":"Curr. Opin. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ganaie, S.S., and Qiu, J. (2018). Recent Advances in Replication and Infection of Human Parvovirus B19. Front. Cell. Infect. Microbiol., 8.","DOI":"10.3389\/fcimb.2018.00166"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11628","DOI":"10.1073\/pnas.0402992101","article-title":"The structure of human parvovirus B19","volume":"101","author":"Kaufmann","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1128\/JVI.00512-08","article-title":"Visualization of the externalized VP2 N termini of infectious human parvovirus B19","volume":"82","author":"Kaufmann","year":"2008","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1128\/JVI.76.4.2014-2018.2002","article-title":"The VP1 unique region of parvovirus B19 and its constituent phospholipase A2-like activity","volume":"76","author":"Dorsch","year":"2002","journal-title":"J. Virol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1017\/S0950268807009661","article-title":"Parvovirus B19 infection in five European countries: Seroepidemiology, force of infection and maternal risk of infection","volume":"136","author":"Mossong","year":"2008","journal-title":"Epidemiol. Infect."},{"key":"ref_11","unstructured":"Rezaei, N. (2022). Parvoviridae. Encyclopedia of Infection and Immunity, Elsevier."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2217\/fvl.14.103","article-title":"Human parvovirus B19: A mechanistic overview of infection and DNA replication","volume":"10","author":"Luo","year":"2015","journal-title":"Future Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.virusres.2014.06.017","article-title":"Persistent parvovirus B19 infection in non-erythroid tissues: Possible role in the inflammatory and disease process","volume":"190","author":"Ignatovich","year":"2014","journal-title":"Virus Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMicm1807156","article-title":"Images in clinical medicine. Parvovirus B19 Infection","volume":"379","author":"Mende","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/JVI.02247-07","article-title":"Ex vivo-generated CD36+ erythroid progenitors are highly permissive to human parvovirus B19 replication","volume":"82","author":"Wong","year":"2008","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Filippone, C., Franssila, R., Kumar, A., Saikko, L., Kovanen, P.E., Soderlund-Venermo, M., and Hedman, K. (2010). Erythroid progenitor cells expanded from peripheral blood without mobilization or preselection: Molecular characteristics and functional competence. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009496"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12385","DOI":"10.1128\/JVI.01229-10","article-title":"Role of erythropoietin receptor signaling in parvovirus B19 replication in human erythroid progenitor cells","volume":"84","author":"Chen","year":"2010","journal-title":"J. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bua, G., Manaresi, E., Bonvicini, F., and Gallinella, G. (2016). Parvovirus B19 Replication and Expression in Differentiating Erythroid Progenitor Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148547"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2004.06.020","article-title":"Hypoxia enhances human B19 erythrovirus gene expression in primary erythroid cells","volume":"327","author":"Pillet","year":"2004","journal-title":"Virology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1126\/science.8211117","article-title":"Erythrocyte P antigen: Cellular receptor for B19 parvovirus","volume":"262","author":"Brown","year":"1993","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1056\/NEJM199404283301704","article-title":"Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen)","volume":"330","author":"Brown","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e00972-19","DOI":"10.1128\/JVI.00972-19","article-title":"Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection","volume":"93","author":"Bieri","year":"2019","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bieri, J., Leisi, R., Bircher, C., and Ros, C. (2021). Human parvovirus B19 interacts with globoside under acidic conditions as an essential step in endocytic trafficking. PLoS Pathog., 17.","DOI":"10.1101\/2021.03.02.433539"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1182\/blood-2003-05-1522","article-title":"Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: Requirement of functional activation of beta1 integrin for viral entry","volume":"102","author":"Yoder","year":"2003","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13161","DOI":"10.1128\/JVI.02548-13","article-title":"Parvovirus B19 uptake is a highly selective process controlled by VP1u, a novel determinant of viral tropism","volume":"87","author":"Leisi","year":"2013","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Leisi, R., Di Tommaso, C., Kempf, C., and Ros, C. (2016). The Receptor-Binding Domain in the VP1u Region of Parvovirus B19. Viruses, 8.","DOI":"10.3390\/v8030061"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Leisi, R., Von Nordheim, M., Ros, C., and Kempf, C. (2016). The VP1u Receptor Restricts Parvovirus B19 Uptake to Permissive Erythroid Cells. Viruses, 8.","DOI":"10.3390\/v8100265"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11737","DOI":"10.1128\/JVI.01143-10","article-title":"The globoside receptor triggers structural changes in the B19 virus capsid that facilitate virus internalization","volume":"84","author":"Bonsch","year":"2010","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"eade0869","DOI":"10.1126\/sciadv.ade0869","article-title":"Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors","volume":"9","author":"Ning","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/viro.2000.0673","article-title":"Different patterns of restriction to B19 parvovirus replication in human blast cell lines","volume":"278","author":"Gallinella","year":"2000","journal-title":"Virology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9951","DOI":"10.1128\/JVI.01162-08","article-title":"Block to the production of full-length B19 virus transcripts by internal polyadenylation is overcome by replication of the viral genome","volume":"82","author":"Guan","year":"2008","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e01881-17","DOI":"10.1128\/JVI.01881-17","article-title":"Human Parvovirus B19 Utilizes Cellular DNA Replication Machinery for Viral DNA Replication","volume":"92","author":"Zou","year":"2018","journal-title":"J. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.virol.2013.11.031","article-title":"The human parvovirus B19 non-structural protein 1 N-terminal domain specifically binds to the origin of replication in the viral DNA","volume":"449","author":"Tewary","year":"2014","journal-title":"Virology"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ganaie, S.S., Zou, W., Xu, P., Deng, X., Kleiboeker, S., and Qiu, J. (2017). Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006370"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e02050-17","DOI":"10.1128\/JVI.02050-17","article-title":"RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication","volume":"92","author":"Ganaie","year":"2018","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e00192-20","DOI":"10.1128\/mBio.00192-20","article-title":"RNA Binding Motif Protein RBM45 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19 through Binding to Novel Intron Splicing Enhancers","volume":"11","author":"Wang","year":"2020","journal-title":"mBio"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.virol.2005.12.014","article-title":"Parvovirus B19 genome as a single, two-state replicative and transcriptional unit","volume":"347","author":"Bonvicini","year":"2006","journal-title":"Virology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.virol.2008.09.002","article-title":"Functional analysis and quantitative determination of the expression profile of human parvovirus B19","volume":"381","author":"Bonvicini","year":"2008","journal-title":"Virology"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Xu, P., Zhou, Z., Xiong, M., Zou, W., Deng, X., Ganaie, S.S., Kleiboeker, S., Peng, J., Liu, K., and Wang, S. (2017). Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006266"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1172\/JCI41805","article-title":"Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors","volume":"120","author":"Wan","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00281-002-0099-6","article-title":"Human parvovirus B19-induced cell cycle arrest and apoptosis","volume":"24","author":"Morita","year":"2002","journal-title":"Semin. Immunopathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood-2009-04-215756","article-title":"The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells","volume":"115","author":"Chen","year":"2010","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.blre.2013.12.002","article-title":"Bone marrow necrosis and fat embolism syndrome in sickle cell disease: Increased susceptibility of patients with non-SS genotypes and a possible association with human parvovirus B19 infection","volume":"28","author":"Tsitsikas","year":"2014","journal-title":"Blood Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2217\/fvl-2017-0079","article-title":"How does parvovirus B19 DNA achieve lifelong persistence in human cells?","volume":"12","author":"Bua","year":"2017","journal-title":"Future Virol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bua, G., Marrazzo, P., Manaresi, E., Gamberini, C., Bonsi, L., Alviano, F., and Gallinella, G. (2023). Non-Permissive Parvovirus B19 Infection: A Reservoir and Questionable Safety Concern in Mesenchymal Stem Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098204"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7942","DOI":"10.1128\/JVI.00891-08","article-title":"Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3\/PIAS3 in human endothelial cells","volume":"82","author":"Duechting","year":"2008","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2005.05.003","article-title":"Human parvovirus B19 experimental infection in human fibroblasts and endothelial cells cultures","volume":"114","author":"Zakrzewska","year":"2005","journal-title":"Virus Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/art.10346","article-title":"Parvovirus B19 infection of cultured skin fibroblasts from systemic sclerosis patients: Comment on the article by Ray et al","volume":"46","author":"Ferri","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"14930","DOI":"10.1038\/ncomms14930","article-title":"Extinct type of human parvovirus B19 persists in tonsillar B cells","volume":"8","author":"Pyoria","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1128\/JVI.00649-14","article-title":"Antibody-mediated enhancement of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q","volume":"88","author":"Pozzuto","year":"2014","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.virol.2005.09.040","article-title":"Human parvovirus B19 infection of monocytic cell line U937 and antibody-dependent enhancement","volume":"345","author":"Munakata","year":"2006","journal-title":"Virology"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bonvicini, F., Manaresi, E., Di Furio, F., De Falco, L., and Gallinella, G. (2012). Parvovirus b19 DNA CpG dinucleotide methylation and epigenetic regulation of viral expression. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033316"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/ejhf.665","article-title":"Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: Review of the literature","volume":"18","author":"Verdonschot","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2249.2006.03286.x","article-title":"Cytokine responses in acute and persistent human parvovirus B19 infection","volume":"147","author":"Isa","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1086\/382963","article-title":"B cell memory is directed toward conformational epitopes of parvovirus B19 capsid proteins and the unique region of VP1","volume":"189","author":"Corcoran","year":"2004","journal-title":"J. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0264-410X(00)00258-9","article-title":"Mapping of B-cell epitopes on human parvovirus B19 non-structural and structural proteins","volume":"19","author":"Tolfvenstam","year":"2000","journal-title":"Vaccine"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/(SICI)1096-9071(200003)60:3<347::AID-JMV15>3.0.CO;2-T","article-title":"Immunoreactivity against linear epitopes of parvovirus B19 structural proteins. Immunodominance of the amino-terminal half of the unique region of VP1","volume":"60","author":"Musiani","year":"2000","journal-title":"J. Med. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0163-4453(96)80008-9","article-title":"Autoantibodies following parvovirus B19 infection","volume":"32","author":"Kerr","year":"1996","journal-title":"J. Infect."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/(SICI)1521-4141(199803)28:03<936::AID-IMMU936>3.0.CO;2-X","article-title":"Chronic parvovirus B19 infection induces the production of anti-virus antibodies with autoantigen binding properties","volume":"28","author":"Lunardi","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0140-6736(85)91145-6","article-title":"Human parvovirus arthropathy","volume":"1","author":"White","year":"1985","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0140-6736(85)91146-8","article-title":"Human parvovirus-associated arthritis: A clinical and laboratory description","volume":"1","author":"Reid","year":"1985","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1099\/0022-1317-73-6-1559","article-title":"Non-permissiveness of synovial membrane cells to human parvovirus B19 in vitro","volume":"73","author":"Miki","year":"1992","journal-title":"J. Gen. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10067-003-0800-8","article-title":"Parvovirus B19-related chronic monoarthritis: Immunohistochemical detection of virus-positive lymphocytes within the synovial tissue compartment: Two reported cases","volume":"23","author":"Lennerz","year":"2004","journal-title":"Clin. Rheumatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/01.MP.0000083145.68333.9B","article-title":"Detection of parvovirus B19 capsid proteins in lymphocytic cells in synovial tissue of autoimmune chronic arthritis","volume":"16","author":"Mehraein","year":"2003","journal-title":"Mod. Pathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/1529-0131(200107)44:7<1582::AID-ART281>3.0.CO;2-E","article-title":"Induction of an invasive phenotype by human parvovirus B19 in normal human synovial fibroblasts","volume":"44","author":"Ray","year":"2001","journal-title":"Arthritis Rheum."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1086\/499599","article-title":"Activation of synoviocytes by the secreted phospholipase A2 motif in the VP1-unique region of parvovirus B19 minor capsid protein","volume":"193","author":"Lu","year":"2006","journal-title":"J. Infect. Dis."},{"key":"ref_67","first-page":"595","article-title":"Chronic fatigue syndrome and arthralgia following parvovirus B19 infection","volume":"29","author":"Kerr","year":"2002","journal-title":"J. Rheumatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1086\/374666","article-title":"Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome","volume":"36","author":"Kerr","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcv.2014.11.021","article-title":"Paradoxical response to intravenous immunoglobulin in a case of Parvovirus B19-associated chronic fatigue syndrome","volume":"62","author":"Attard","year":"2015","journal-title":"J. Clin. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/jclinpath-2015-203455","article-title":"The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease","volume":"69","author":"Kerr","year":"2016","journal-title":"J. Clin. Pathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/092986606775101715","article-title":"Autoantibody reaction to myelin basic protein by plasma parvovirus B19 IgG in MS patients","volume":"13","author":"Thomas","year":"2006","journal-title":"Protein Pept. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/exmp.1999.2243","article-title":"Apoptotic cells as immunogen and antigen in the antiphospholipid syndrome","volume":"66","author":"Levine","year":"1999","journal-title":"Exp. Mol. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Thammasri, K., Rauhamaki, S., Wang, L., Filippou, A., Kivovich, V., Marjomaki, V., Naides, S.J., and Gilbert, L. (2013). Human parvovirus B19 induced apoptotic bodies contain altered self-antigens that are phagocytosed by antigen presenting cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0067179"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1534-5807(01)00031-4","article-title":"A viral phospholipase A2 is required for parvovirus infectivity","volume":"1","author":"Zadori","year":"2001","journal-title":"Dev. Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1002\/art.11038","article-title":"Antiphospholipid antibodies in pediatric and adult patients with rheumatic disease are associated with parvovirus B19 infection","volume":"48","author":"Lehmann","year":"2003","journal-title":"Arthritis Rheum."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1568-9972(03)00014-4","article-title":"Parvovirus B19 infection and autoimmune disease","volume":"2","author":"Lehmann","year":"2003","journal-title":"Autoimmun. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cca.2006.10.016","article-title":"The association of VP1 unique region protein in acute parvovirus B19 infection and anti-phospholipid antibody production","volume":"378","author":"Tzang","year":"2007","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cca.2010.04.004","article-title":"The association of anti-parvovirus B19-VP1 unique region antibodies with antiphospholipid antibodies in patients with antiphospholipid syndrome","volume":"411","author":"Chen","year":"2010","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02686079","article-title":"Auto-antibodies and autoreactive T-cells in rheumatoid arthritis: Pathogenetic players and diagnostic tools","volume":"32","author":"Steiner","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/art.1780330901","article-title":"Rheumatologic manifestations of human parvovirus B19 infection in adults. Initial two-year clinical experience","volume":"33","author":"Naides","year":"1990","journal-title":"Arthritis Rheum."},{"key":"ref_81","first-page":"147","article-title":"Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis","volume":"12","author":"Saal","year":"1992","journal-title":"Rheumatology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/rheumatology\/34.9.809","article-title":"A study of the role of parvovirus B19 in rheumatoid arthritis","volume":"34","author":"Kerr","year":"1995","journal-title":"Br. J. Rheumatol."},{"key":"ref_83","first-page":"1","article-title":"Human Parvovirus B19 Infection in Rheumatoid Arthritis Patients: Screening and Clinical Significance","volume":"25","author":"Aboelazm","year":"2018","journal-title":"Egypt. J. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1073\/pnas.95.14.8227","article-title":"Human parvovirus B19 as a causative agent for rheumatoid arthritis","volume":"95","author":"Takahashi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.4049\/jimmunol.173.7.4675","article-title":"Human parvovirus B19 transgenic mice become susceptible to polyarthritis","volume":"173","author":"Takasawa","year":"2004","journal-title":"J. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/infdis\/172.5.1356","article-title":"Antibodies to the nonstructural protein of parvovirus B19 in persistently infected patients: Implications for pathogenesis","volume":"172","author":"Hemauer","year":"1995","journal-title":"J. Infect. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/rheumatology\/39.8.903","article-title":"Antibodies to parvovirus B19 non-structural protein are associated with chronic but not acute arthritis following B19 infection","volume":"39","author":"Kerr","year":"2000","journal-title":"Rheumatology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.medici.2015.01.004","article-title":"Use of exploratory factor analysis to ascertain the correlation between the activities of rheumatoid arthritis and infection by human parvovirus B19","volume":"51","author":"Kakurina","year":"2015","journal-title":"Medicina"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1099\/jgv.0.000621","article-title":"Frequency and significance of parvovirus B19 infection in patients with rheumatoid arthritis","volume":"97","author":"Naciute","year":"2016","journal-title":"J. Gen. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1546-0096-12-22","article-title":"Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after onset of juvenile idiopathic arthritis (JIA)","volume":"12","author":"Berntson","year":"2014","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/0140-6736(93)91184-N","article-title":"Adult Still\u2019s disease associated with acute human parvovirus B19 infection","volume":"341","author":"Pouchot","year":"1993","journal-title":"Lancet"},{"key":"ref_92","first-page":"1336","article-title":"Parvovirus B19 may have a role in the pathogenesis of juvenile idiopathic arthritis","volume":"34","author":"Gonzalez","year":"2007","journal-title":"J. Rheumatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10067-007-0718-7","article-title":"Different patterns of disease manifestations of parvovirus B19-associated reactive juvenile arthritis and the induction of antiphospholipid-antibodies","volume":"27","author":"Lehmann","year":"2008","journal-title":"Clin. Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Benfaremo, D., Svegliati, S., Paolini, C., Agarbati, S., and Moroncini, G. (2022). Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010163"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00281-015-0551-z","article-title":"Systemic sclerosis and localized scleroderma--current concepts and novel targets for therapy","volume":"38","author":"Distler","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11926-015-0552-x","article-title":"Fresh Insights into Disease Etiology and the Role of Microbial Pathogens","volume":"18","author":"Farina","year":"2016","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_97","first-page":"267","article-title":"Parvovirus B19 and systemic sclerosis","volume":"17","author":"Ferri","year":"1999","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_98","first-page":"718","article-title":"Parvovirus B19 infection of bone marrow in systemic sclerosis patients","volume":"17","author":"Ferri","year":"1999","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/j.0007-0963.2004.05930.x","article-title":"Increased prevalence of human parvovirus B19 DNA in systemic sclerosis skin","volume":"150","author":"Ohtsuka","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000232945","article-title":"Human parvovirus B19 (B19V) infection in systemic sclerosis patients","volume":"52","author":"Zakrzewska","year":"2009","journal-title":"Intervirology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.0303-6987.2003.0143.x","article-title":"Parvoviral infection of endothelial cells and stromal fibroblasts: A possible pathogenetic role in scleroderma","volume":"31","author":"Magro","year":"2004","journal-title":"J. Cutan. Pathol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1093\/rheumatology\/keaa230","article-title":"Parvovirus B19 activates in vitro normal human dermal fibroblasts: A possible implication in skin fibrosis and systemic sclerosis","volume":"59","author":"Arvia","year":"2020","journal-title":"Rheumatology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/infdis\/jiv178","article-title":"Impaired Endothelial Regeneration through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients with Cardiomyopathy","volume":"212","author":"Zobel","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1002\/art.20562","article-title":"Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis","volume":"50","author":"Fibbi","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/path.2048","article-title":"Systemic sclerosis fibroblasts inhibit in vitro angiogenesis by MMP-12-dependent cleavage of the endothelial cell urokinase receptor","volume":"210","author":"Serrati","year":"2006","journal-title":"J. Pathol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1093\/rheumatology\/keab904","article-title":"Parvovirus B19 (B19V) induces cellular senescence in human dermal fibroblasts: Putative role in SSc-associated fibrosis","volume":"61","author":"Arvia","year":"2021","journal-title":"Rheumatology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11926-018-0712-x","article-title":"Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations","volume":"20","author":"Schafer","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/art.38702","article-title":"Review: Interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: How similar and distinct?","volume":"66","author":"Herzog","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s10067-013-2289-0","article-title":"Mortality in systemic sclerosis-a single centre study from the UK","volume":"32","author":"Strickland","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1038\/jid.2014.69","article-title":"Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts","volume":"134","author":"Dumit","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1128\/JVI.76.11.5395-5403.2002","article-title":"Regulation of tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2","volume":"76","author":"Fu","year":"2002","journal-title":"J. Virol."},{"key":"ref_112","first-page":"3364","article-title":"Human parvovirus B19 nonstructural protein NS1 activates NLRP3 inflammasome signaling in adult-onset Still\u2019s disease","volume":"17","author":"Chen","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Reggiani, A., Avati, A., Valenti, F., Fasano, E., Bua, G., Manaresi, E., and Gallinella, G. (2022). A Functional Minigenome of Parvovirus B19. Viruses, 14.","DOI":"10.3390\/v14010084"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/infdis\/jix309","article-title":"Human Parvovirus B19 (B19V) Up-regulates CXCR4 Surface Expression of Circulating Angiogenic Cells: Implications for Cardiac Ischemia in B19V Cardiomyopathy","volume":"217","author":"Zobel","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Zobel, T., Bock, C.T., Kuhl, U., Rohde, M., Lassner, D., Schultheiss, H.P., and Schmidt-Lucke, C. (2019). Telbivudine Reduces Parvovirus B19-Induced Apoptosis in Circulating Angiogenic Cells. Viruses, 11.","DOI":"10.3390\/v11030227"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.imlet.2017.09.001","article-title":"Toll Like Receptors in systemic sclerosis: An emerging target","volume":"195","year":"2018","journal-title":"Immunol. Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/art.23451","article-title":"Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma","volume":"58","author":"Duan","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.imlet.2018.03.011","article-title":"Different profile of cytokine production in patients with systemic sclerosis and association with clinical manifestations","volume":"198","author":"Dantas","year":"2018","journal-title":"Immunol. Lett."},{"key":"ref_119","first-page":"3786","article-title":"IL-1R1\/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice","volume":"117","author":"Gasse","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13071-018-3223-8","article-title":"NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-kappaB","volume":"12","author":"Zhang","year":"2019","journal-title":"Parasit Vectors"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1002\/art.30568","article-title":"The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis","volume":"63","author":"Artlett","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Delaloye, J., Roger, T., Steiner-Tardivel, Q.G., Le Roy, D., Knaup Reymond, M., Akira, S., Petrilli, V., Gomez, C.E., Perdiguero, B., and Tschopp, J. (2009). Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000480"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ni.1861","article-title":"Influenza virus activates inflammasomes via its intracellular M2 ion channel","volume":"11","author":"Ichinohe","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.jid.2019.03.1144","article-title":"Effects of Parvovirus B19 In Vitro Infection on Monocytes from Patients with Systemic Sclerosis: Enhanced Inflammatory Pathways by Caspase-1 Activation and Cytokine Production","volume":"139","author":"Zakrzewska","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.virol.2010.12.019","article-title":"Transactivation of human parvovirus B19 gene expression in endothelial cells by adenoviral helper functions","volume":"411","author":"Pozzuto","year":"2011","journal-title":"Virology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4330\/wjc.v6.i4.183","article-title":"Molecular phenotypes of human parvovirus B19 in patients with myocarditis","volume":"6","author":"Bock","year":"2014","journal-title":"World J. Cardiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Pan, Q., Liu, Z., Liao, S., Ye, L., Lu, X., Chen, X., Li, Z., Li, X., Xu, Y.Z., and Liu, H. (2019). Current mechanistic insights into the role of infection in systemic lupus erythematosus. Biomed. Pharmacother., 117.","DOI":"10.1016\/j.biopha.2019.109122"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0049-0172(99)80016-X","article-title":"Human parvovirus B19 infection: Its relationship with systemic lupus erythematosus","volume":"28","author":"Trapani","year":"1999","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/rheumatology\/32.2.158","article-title":"Exacerbation of systemic lupus erythematosus during human parvovirus B19 infection","volume":"32","author":"Chassagne","year":"1993","journal-title":"Br. J. Rheumatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1386-6532(99)00038-4","article-title":"Acute parvovirus B19 infection in connection with a flare of systemic lupus erythematodes in a female patient","volume":"14","author":"Hemauer","year":"1999","journal-title":"J. Clin. Virol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1385\/CRIAI:25:1:41","article-title":"Systemic lupus erythematosus and parvovirus B19: Casual coincidence or causative culprit?","volume":"25","author":"Severin","year":"2003","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejim.2007.09.013","article-title":"Parvovirus B19 infection and systemic lupus erythematosus: Activation of an aberrant pathway?","volume":"19","author":"Aslanidis","year":"2008","journal-title":"Eur. J. Intern. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcv.2015.09.007","article-title":"Human parvovirus B19 and autoimmune diseases. Review of the literature and pathophysiological hypotheses","volume":"72","author":"Page","year":"2015","journal-title":"J. Clin. Virol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/path.1711690207","article-title":"Ultrastructural features of fetal erythroid precursors infected with parvovirus B19 in vitro: Evidence of cell death by apoptosis","volume":"169","author":"Morey","year":"1993","journal-title":"J. Pathol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1099\/0022-1317-82-12-3011","article-title":"Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue","volume":"82","author":"Kerr","year":"2001","journal-title":"J. Gen. Virol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.trsl.2020.04.006","article-title":"Antiphospholipid syndrome","volume":"225","author":"Petri","year":"2020","journal-title":"Transl. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12026-017-8896-0","article-title":"Does parvovirus infection have a role in systemic lupus erythematosus?","volume":"65","author":"Hod","year":"2017","journal-title":"Immunol. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/21505594.2017.1385691","article-title":"Antigenicity analysis of human parvovirus B19-VP1u protein in the induction of anti-phospholipid syndrome","volume":"9","author":"Lin","year":"2018","journal-title":"Virulence"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Chen, D.Y., Chen, Y.M., Tzang, B.S., Lan, J.L., and Hsu, T.C. (2014). Th17-related cytokines in systemic lupus erythematosus patients with dilated cardiomyopathies: A possible linkage to parvovirus B19 infection. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113889"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/ar758","article-title":"Autoantibodies in vasculitis","volume":"5","author":"Wiik","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(94)92154-7","article-title":"Active or recent parvovirus B19 infection in children with Kawasaki disease","volume":"343","author":"Nigro","year":"1994","journal-title":"Lancet"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0140-6736(94)91080-4","article-title":"Human parvovirus B19 infection in Kawasaki disease","volume":"344","author":"Yoto","year":"1994","journal-title":"Lancet"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00006454-200005000-00019","article-title":"Lack of association between Kawasaki syndrome and infection with parvovirus B19, human herpesvirus 8, TT virus, GB virus C\/hepatitis G virus or Chlamydia pneumoniae","volume":"19","author":"Chua","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/INF.0b013e318199302b","article-title":"Absence of parvoviral genomes in endothelial cells of Kawasaki disease patients with coronary artery lesions","volume":"28","author":"Bowles","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1034\/j.1600-0560.2002.291006.x","article-title":"Parvovirus B19 associated adult Henoch Sch\u00f6nlein purpura","volume":"29","author":"Cioc","year":"2002","journal-title":"J. Cutan. Pathol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00006454-200201000-00007","article-title":"Parvovirus B19 and parvovirus V9 are not associated with Henoch-Schonlein purpura in children","volume":"21","author":"Heegaard","year":"2002","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1056\/NEJM200105103441919","article-title":"Treatment of parvovirus-associated polyarteritis nodosa with intravenous immune globulin","volume":"344","author":"Viguier","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/ard.2005.040113","article-title":"No evidence of parvovirus B19 in tissue samples from patients with polyarteritis nodosa and microscopic polyangiitis as assessed by the polymerase chain reaction","volume":"65","author":"Sachetto","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2230.2006.02330.x","article-title":"Detection of parvovirus B19 DNA in the lesional skin of patients with Behcet\u2019s disease","volume":"32","author":"Baskan","year":"2007","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_152","first-page":"493","article-title":"No Definite Association between Human Parvovirus B19 Infection and Behcet Disease","volume":"40","author":"Habibagahi","year":"2015","journal-title":"Iran J Med Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/art.1780371122","article-title":"Wegener\u2019s granulomatosis and parvovirus B19 infection","volume":"37","author":"Nikkari","year":"1994","journal-title":"Arthritis Rheum."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/rheumatology\/keg206","article-title":"Lack of association between B19 or V9 erythrovirus infection and ANCA-positive vasculitides: A case-control study","volume":"42","author":"Eden","year":"2003","journal-title":"Rheumatology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/14737159.2018.1503537","article-title":"The clinical use of parvovirus B19 assays: Recent advances","volume":"18","author":"Gallinella","year":"2018","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Manaresi, E., and Gallinella, G. (2019). Advances in the Development of Antiviral Strategies against Parvovirus B19. Viruses, 11.","DOI":"10.3390\/v11070659"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Hu, X., Jia, C., Wu, J., Zhang, J., Jiang, Z., and Ma, K. (2022). Towards the Antiviral Agents and Nanotechnology-Enabled Approaches Against Parvovirus B19. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.916012"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/8\/1708\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:38:50Z","timestamp":1760110730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/8\/1708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":157,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["microorganisms12081708"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms12081708","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]}}}