{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:15:03Z","timestamp":1792826103646,"version":"4.5.0"},"reference-count":271,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vibrant America"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Purpose of review: This review investigates the oral microbiome\u2019s composition, functions, influencing factors, connections to oral and systemic diseases, and personalized oral care strategies. Recent findings: The oral microbiome is a complex ecosystem consisting of bacteria, fungi, archaea, and viruses that contribute to oral health. Various factors, such as diet, smoking, alcohol consumption, lifestyle choices, and medical conditions, can affect the balance of the oral microbiome and lead to dysbiosis, which can result in oral health issues like dental caries, gingivitis, periodontitis, oral candidiasis, and halitosis. Importantly, our review explores novel associations between the oral microbiome and systemic diseases including gastrointestinal, cardiovascular, endocrinal, and neurological conditions, autoimmune diseases, and cancer. We comprehensively review the efficacy of interventions like dental probiotics, xylitol, oral rinses, fluoride, essential oils, oil pulling, and peptides in promoting oral health by modulating the oral microbiome. Summary: This review emphasizes the critical functions of the oral microbiota in dental and overall health, providing insights into the effects of microbial imbalances on various diseases. It underlines the significant connection between the oral microbiota and general health. Furthermore, it explores the advantages of probiotics and other dental care ingredients in promoting oral health and addressing common oral issues, offering a comprehensive strategy for personalized oral care.<\/jats:p>","DOI":"10.3390\/microorganisms12091797","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T11:33:37Z","timestamp":1724931217000},"page":"1797","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":264,"title":["Oral Microbiome: A Review of Its Impact on Oral and Systemic Health"],"prefix":"10.3390","volume":"12","author":[{"given":"John J.","family":"Rajasekaran","sequence":"first","affiliation":[{"name":"Vibrant Sciences LLC, Santa Clara, CA 95054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-8423","authenticated-orcid":false,"given":"Hari Krishnan","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Vibrant Sciences LLC, Santa Clara, CA 95054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jophi","family":"Bosco","sequence":"additional","affiliation":[{"name":"Vibrant America LLC, Santa Clara, CA 95054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanth","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Vibrant Sciences LLC, Santa Clara, CA 95054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Krishna","sequence":"additional","affiliation":[{"name":"Vibrant Sciences LLC, Santa Clara, CA 95054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Vibrant Sciences LLC, Santa Clara, CA 95054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Bei","sequence":"additional","affiliation":[{"name":"Vibrant Sciences LLC, Santa Clara, CA 95054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","article-title":"Oral microbiome: Unveiling the fundamentals","volume":"23","author":"Deo","year":"2019","journal-title":"J. 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