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So far, classical antifungal agents have been efficient against S. brasiliensis, but here we describe the first case of therapeutic failure and a high minimum inhibitory concentration (MIC) in relation to itraconazole.<\/jats:p>","DOI":"10.3390\/microorganisms12112132","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T05:47:33Z","timestamp":1729748853000},"page":"2132","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evidence of Clinical and Laboratory Correlation of Itraconazole Resistance in Sporothrix\u00a0brasiliensis Infection: Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"John Verrinder","family":"Veasey","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Santa Casa de Sao Paulo, S\u00e3o Paulo 01221010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8962-2532","authenticated-orcid":false,"given":"Ana Paula Carvalho","family":"Reis","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Cl\u00ednicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-1537","authenticated-orcid":false,"given":"Giovanna Azevedo","family":"Celestrino","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Cl\u00ednicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Estacia","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Cl\u00ednicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Cl\u00ednicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Polizel","family":"Mendes","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Cl\u00ednicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-6462","authenticated-orcid":false,"given":"Tania Sueli","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Culture Collection, Adolfo Lutz Institute, Secretary of Health, Sao Paulo 01246000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2554-1853","authenticated-orcid":false,"given":"Lucas Xavier","family":"Bonfietti","sequence":"additional","affiliation":[{"name":"Health Department, Mycology Nucleus of Instituto Adolfo Lutz, S\u00e3o Paulo 01246000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5469-3602","authenticated-orcid":false,"given":"Gil","family":"Benard","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Cl\u00ednicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-1945","authenticated-orcid":false,"given":"Maria Gl\u00f3ria Texeira","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Cl\u00ednicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.abd.2020.11.014","article-title":"Epidemiological and geographical distribution profile of urban sporotrichosis in the city of S\u00e3o Paulo","volume":"97","author":"Veasey","year":"2022","journal-title":"An. 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