{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:58:41Z","timestamp":1773183521027,"version":"3.50.1"},"reference-count":8,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, Bucharest"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Leuconostoc pseudomesenteroides is a rare pathogen that can cause bacteremia in immunocompromised patients, particularly those with hematological conditions like acute myeloid leukemia. In this case, a 56-year-old woman developed Leuconostoc bacteremia following chemotherapy and multiple infections, including invasive aspergillosis. Despite broad-spectrum antibiotic treatments, her fever persisted until the blood cultures identified Leuconostoc pseudomesenteroides. Switching to intravenous ampicillin led to the resolution of symptoms. This case highlights the challenges in diagnosing and treating rare, glycopeptide-resistant bacteria in immunosuppressed patients and underscores the importance of repeated blood cultures and automated diagnostic systems. It also highlights the need for more rapid ways of diagnosing and treating such rare infections.<\/jats:p>","DOI":"10.3390\/microorganisms12112215","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T12:31:32Z","timestamp":1730377892000},"page":"2215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leuconostoc pseudomesenteroides Bacteremia in an Immunocompromised Patient with Hematological Comorbidities\u2014Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Madalina","family":"Simoiu","sequence":"first","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cMatei Bals\u201d, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai-Cezar","family":"Filipescu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cMatei Bals\u201d, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilin","family":"Omer","sequence":"additional","affiliation":[{"name":"Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Maria","family":"Borcan","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cMatei Bals\u201d, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3442-2338","authenticated-orcid":false,"given":"Mihaela-Cristina","family":"Olariu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cMatei Bals\u201d, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref_1","first-page":"e38312","article-title":"Rare Case of Leuconostoc pseudomesenteroides Bacteremia and Refractory Septic Shock","volume":"15","author":"Ghobrial","year":"2023","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kim, E., Yang, S.M., Kim, I.S., Lee, S.Y., and Kim, H.Y. (2022). Identification of Leuconostoc species based on novel marker genes identified using real-time PCR via computational pangenome analysis. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1014872"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.3201\/eid2609.191123","article-title":"Leuconostoc lactis and Staphylococcus nepalensis Bacteremia, Japan","volume":"26","author":"Hosoya","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Azghar, A., Azizi, M., Lahmer, M., Benaissa, E., Ben Lahlou, Y., Benajiba, N., Elouennass, M., and Maleb, A. (2023). A very rare case of bacteraemia in a 4-year-old girl with osteopetrosis with probable Leuconostoc lactis infection. Access Microbiol., 5.","DOI":"10.1099\/acmi.0.000439"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1128\/JCM.37.12.4124-4126.1999","article-title":"Leuconostoc pseudomesenteroides as a cause of nosocomial urinary tract infections","volume":"37","author":"Cappelli","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"ref_6","first-page":"7648628","article-title":"Bacteremia Due to Leuconostoc pseudomesenteroides in a Patient with Acute Lymphoblastic Leukemia: Case Report and Review of the Literature","volume":"2016","author":"Ino","year":"2016","journal-title":"Case Rep. Hematol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wiggers, J.B., Xiong, W., and Daneman, N. (2016). Sending Repeat Cultures: Is There a Role in the Management of Bacteremic Episodes? (Scribe Study). BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1622-z"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1128\/JCM.40.5.1681-1686.2002","article-title":"Evaluation of the vitek 2 system for identification and antimicrobial susceptibility testing of medically relevant gram-positive cocci","volume":"40","author":"Ligozzi","year":"2002","journal-title":"J. Clin. Microbiol."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/11\/2215\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:26:08Z","timestamp":1760113568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/11\/2215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["microorganisms12112215"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms12112215","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]}}}