{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:04:15Z","timestamp":1788494655399,"version":"build-2803163510"},"reference-count":159,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Science and Innovation"},{"name":"CSIR\u2019s Special Initiatives Parliamentary Grant Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The use of probiotics has been gaining popularity in terms of inclusion into human diets over recent years. Based on properties exerted by these organisms, several benefits have been elucidated and conferred to the host. Bacteria have been more commonly used in probiotic preparations compared to yeast candidates; however, yeast exhibit several beneficial properties, such as the prevention and treatment of diarrhea, the production of antimicrobial agents, the prevention of pathogen adherence to intestinal sites, the maintenance of microbial balance, the modulation of the immune system, antibiotic resistance, amongst others. Saccharomyces boulardii is by far the most studied strain; however, the potential for the use of other yeast candidates, such as Kluyveromyces lactis and Debaryomyces hansenii, amongst others, have also been evaluated in this review. Furthermore, a special focus has been made regarding the production considerations for yeast-based probiotics and their formulation into different delivery formats. When drafting this review, evidence suggests that the use of yeasts, both wild-type and genetically modified candidates, can extend beyond gut health to support skin, the respiratory system, and overall immune health. Hence, this review explores the potential of yeast probiotics as a safe, effective strategy for preventative health in humans, highlighting their mechanisms of action, clinical applications, and production considerations.<\/jats:p>","DOI":"10.3390\/microorganisms12112233","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T10:57:20Z","timestamp":1730717840000},"page":"2233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Advances in Yeast Probiotic Production and Formulation for Preventative Health"],"prefix":"10.3390","volume":"12","author":[{"given":"Ghaneshree","family":"Moonsamy","sequence":"first","affiliation":[{"name":"Council for Scientific and Industrial Research (CSIR) Future Production Chemicals, Meiring Naude Drive, Pretoria 0081, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yrielle","family":"Roets-Dlamini","sequence":"additional","affiliation":[{"name":"Council for Scientific and Industrial Research (CSIR) Future Production Chemicals, Meiring Naude Drive, Pretoria 0081, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cebeni Nkosihawukile","family":"Langa","sequence":"additional","affiliation":[{"name":"Council for Scientific and Industrial Research (CSIR) Future Production Chemicals, Meiring Naude Drive, Pretoria 0081, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Omrajah","family":"Ramchuran","sequence":"additional","affiliation":[{"name":"Council for Scientific and Industrial Research (CSIR) Future Production Chemicals, Meiring Naude Drive, Pretoria 0081, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Altieri, C. (2016). Dairy propionibacteria as probiotics: Recent evidences. World J. Microbiol. Biotechnol., 32.","DOI":"10.1007\/s11274-016-2118-0"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ma, J., Lyu, Y., Liu, X., Jia, X., Cui, F., Wu, X., Deng, S., and Yue, C. (2022). Engineered probiotics. Microb. Cell Factories, 21.","DOI":"10.1186\/s12934-022-01799-0"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sen, S., and Mansell, T.J. (2020). Yeasts as probiotics: Mechanisms, outcomes, and future potential. Fungal Genet. Biol., 137.","DOI":"10.1016\/j.fgb.2020.103333"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/1040841X.2016.1179622","article-title":"Cellular and molecular effects of yeast probiotics on cancer","volume":"43","author":"Saber","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/jam.13548","article-title":"Biotechnological application of yeasts in food science: Starter cultures, probiotics and enzyme production","volume":"123","author":"Corbo","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1365-2036.2007.03442.x","article-title":"Review article: Yeast as probiotics\u2014Saccharomyces boulardii","volume":"26","author":"Czerucka","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_8","first-page":"63","article-title":"Assimilation of cholesterol and probiotic characterisation of yeast strains isolated from raw milk and fermented foods","volume":"69","year":"2015","journal-title":"Int. J. Dairy Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12602-015-9201-y","article-title":"Characterization of Candida famata Isolated from Poultry Feces for Possible Probiotic Applications","volume":"7","author":"Flahaut","year":"2015","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/jam.12875","article-title":"Probiotic potentials of yeasts isolated from some cereal-based Nigerian traditional fermented food products","volume":"119","author":"Ogunremi","year":"2015","journal-title":"J. Appl. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ochangco, H.S., Gamero, A., Smith, I.M., Christensen, J.E., Jespersen, L., and Arneborg, N. (2016). In vitro investigation of Debaryomyces hansenii strains for potential probiotic properties. World J. Microbiol. Biotechnol., 32.","DOI":"10.1007\/s11274-016-2109-1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/jam.12228","article-title":"Yeasts from autochthonal cheese starters: Technological and functional properties","volume":"115","author":"Binetti","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/lam.12481","article-title":"Non-Saccharomyces yeasts protect against epithelial cell barrier disruption induced by Salmonella enterica subsp. enterica serovar Typhimurium","volume":"61","author":"Smith","year":"2015","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11274-013-1419-9","article-title":"Yeasts from kefir grains: Isolation, identification, and probiotic characterization","volume":"30","author":"Diosma","year":"2014","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1007\/s00253-015-6696-9","article-title":"Pichia pastoris X-33 has probiotic properties with remarkable antibacterial activity against Salmonella Typhimurium","volume":"99","author":"Haubert","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fm.2014.07.011","article-title":"Selection of yeasts with multifunctional features for application as starters in natural black table olive processing","volume":"46","author":"Bonatsou","year":"2015","journal-title":"Food Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1678-4324-75years-2021200658","article-title":"Selenium-Enriched Probiotic Saccharomyces boulardii CCT 4308 Biomass Production Using Low-Cost Sugarcane Molasses Medium","volume":"64","author":"Kitamura","year":"2021","journal-title":"Braz. Arch. Biol. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.3748\/wjg.v25.i18.2188","article-title":"Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections","volume":"25","author":"Czerucka","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_19","first-page":"1131","article-title":"Brewer\u2019s Yeast Improves Glycemic Indices in Type 2 Diabetes Mellitus","volume":"4","author":"Hosseinzadeh","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fakruddin, M., Hossain, M.N., and Ahmed, M. (2017). M Antimicrobial and antioxidant activities of Saccharomyces cerevisiae IFST062013, a potential probiotic. BMC Complement. Altern. Med., 17.","DOI":"10.1186\/s12906-017-1591-9"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Staniszewski, A., and Kordowska-Wiater, M. (2021). Probiotic and Potentially Probiotic Yeasts\u2014Characteristics and Food Application. Foods, 10.","DOI":"10.3390\/foods10061306"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s10068-018-0310-8","article-title":"Potential probiotic characterization and effect of encapsulation of probiotic yeast strains on survival in simulated gastrointestinal tract condition","volume":"27","author":"Suvarna","year":"2018","journal-title":"Food Sci. Biotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Jiang, J., Yue, Y., Feng, Z., Chen, J., and Ye, X. (2020). Influence of mixed probiotics on the the bioactive composition, antioxidant activity and appearance of fermented red bayberry pomace. LWT, 133.","DOI":"10.1016\/j.lwt.2020.110076"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.foodres.2018.02.054","article-title":"Probiotic potential of yeasts isolated from pineapple and their use in the elaboration of potentially functional fermented beverages","volume":"107","author":"Amorim","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Patil, A., and Singh, N. (2023). Probiotics in the Treatment of Gastrointestinal Disorders and What We Know About Their Effect on Microbiota. Preprints.","DOI":"10.20944\/preprints202308.1394.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1021\/acsabm.8b00102","article-title":"Transdermal Delivery of Living and Biofunctional Probiotics through Dissolvable Microneedle Patches","volume":"1","author":"Chen","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Patarroyo, J.L., Florez-Rojas, J.S., Pradilla, D., Valderrama-Rinc\u00f3n, J.D., Cruz, J.C., and Reyes, L.H. (2020). Formulation and Characterization of Gelatin-Based Hydrogels for the Encapsulation of Kluyveromyces lactis\u2014Applications in Packed-Bed Reactors and Probiotics Delivery in Humans. Polymers, 12.","DOI":"10.3390\/polym12061287"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.lwt.2017.03.060","article-title":"Single and double layered microencapsulation of probiotics by spray drying and spray chilling","volume":"81","author":"Erbas","year":"2017","journal-title":"LWT"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1007\/s11095-007-9528-5","article-title":"Increased Intestinal Delivery of Viable Saccharomyces boulardii by Encapsulation in Microspheres","volume":"25","author":"Graff","year":"2008","journal-title":"Pharm. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yang, A.-M., Lin, C.-Y., Liu, S.-H., Syu, G.-D., Sun, H.-J., Lee, K.-C., Lin, H.-C., and Hou, M.-C. (2022). Saccharomyces boulardii Ameliorates Non-alcoholic Steatohepatitis in Mice Induced by a Methionine-Choline-Deficient Diet Through Gut-Liver Axis. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.887728"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3920\/BM2020.0180","article-title":"Lacticaseibacillus rhamnosus GG and Saccharomyces cerevisiae boulardii supplementation exert protective effects on human gut microbiome following antibiotic administration in vitro","volume":"12","author":"Duysburgh","year":"2021","journal-title":"Benef. Microbes"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"Sperandio","year":"2016","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.aad9378","article-title":"How colonization by microbiota in early life shapes the immune system","volume":"352","author":"Gensollen","year":"2016","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bloemendaal, M., Szopinska-Tokov, J., Belzer, C., Boverhoff, D., Papalini, S., Michels, F., van Hemert, S., Vasquez, A.A., and Aarts, E. (2021). Probiotics-induced changes in gut microbial composition and its effects on cognitive performance after stress: Exploratory analyses. Transl. Psychiatry, 11.","DOI":"10.1038\/s41398-021-01404-9"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.tim.2016.06.008","article-title":"Emerging Technologies for Gut Microbiome Research","volume":"24","author":"Arnold","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Papadimitriou, K., Zoumpopoulou, G., Folign\u00e3, B., Alexandraki, V., Kazou, M., Pot, B., and Tsakalidou, E. (2015). Discovering probiotic microorganisms: In vitro, in vivo, genetic and omics approaches. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.00058"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3934\/microbiol.2018.1.140","article-title":"Bacterial autoaggregation","volume":"4","author":"Trunk","year":"2018","journal-title":"AIMS Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Javed, K., Gul, F., Abbasi, R., Batool, S., Noreen, Z., Bokhari, H., and Javed, S. (2022). In Silico and In Vitro Analysis of Helicobacter pullorum Type Six Secretory Protein Hcp and Its Role in Bacterial Invasion and Pathogenesis. Curr. Microbiol., 79.","DOI":"10.1007\/s00284-022-02892-8"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Pillinger, M., Weber, B., Standen, B., Schmid, M.C., and Kesselring, J.C. (2022). Multi-strain probiotics show increased protection of intestinal epithelial cells against pathogens in rainbow trout (Oncorhynchus mykiss). Aquaculture, 560.","DOI":"10.1016\/j.aquaculture.2022.738487"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ziar, H., and Riazi, A. (2022). Polysorbate 80 improves the adhesion and survival of yogurt starters with cholesterol uptake abilities. Saudi J. Biol. Sci., 29.","DOI":"10.1016\/j.sjbs.2022.103367"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Barzoki, M.G., Malekshahi, S.S., and Shayestehpour, M. (2022). In vitro evaluation of antiviral activity of Shouchella clausii probiotic strain and bacterial supernatant against herpes simplex virus type 1. Arch. Microbiol., 204.","DOI":"10.1007\/s00203-022-03137-9"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Hal\u00e1sz, A., and L\u00e1sztity, R. (2017). Use of yeast biomass in food production. Use of Yeast Biomass in Food Production, CRC Press.","DOI":"10.1201\/9780203734551"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1071\/AN21342","article-title":"Platforms to accelerate biomanufacturing of enzyme and probiotic animal feed supplements: Discovery considerations and manufacturing implications","volume":"62","author":"Speight","year":"2022","journal-title":"Anim. Prod. Sci."},{"key":"ref_45","first-page":"2","article-title":"Development of bioprocess for high density cultivation yield the probiotic Bacillus coagulans and its spores","volume":"5","author":"Pandey","year":"2016","journal-title":"J. Biocience Biotechnol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.17113\/ftb.56.01.18.5491","article-title":"Applications of Microbial Enzymes in Food Industry","volume":"56","author":"Raveendran","year":"2018","journal-title":"Food Technol. Biotechnol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0922-338X(98)80087-1","article-title":"Improvement of filtration performance of stirred ceramic membrane reactor and its application to rapid fermentation of lactic acid by dense cell culture of Lactococcus lactis","volume":"85","author":"Kamoshita","year":"1998","journal-title":"J. Ferment. Bioeng."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1021\/bp050062z","article-title":"A Procedure for High-Yield Spore Production by Bacillus subtilis","volume":"21","author":"Monteiro","year":"2008","journal-title":"Biotechnol. Prog."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ramlucken, U., Lalloo, R., Roets, Y., Moonsamy, G., van Rensburg, C.J., and Thantsha, M. (2020). Advantages of Bacillus-based probiotics in poultry production. Livest. Sci., 241.","DOI":"10.1016\/j.livsci.2020.104215"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/j.biortech.2009.10.047","article-title":"Production of probiotic biomass (Lactobacillus casei) in goat milk whey: Comparison of batch, continuous and fed-batch cultures","volume":"101","author":"Alvarez","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Sieck, J.B., Schild, C., and von Hagen, J. (2017). Perfusion Formats and Their Specific Medium Requirements. Continuous Biomanufacturing\u2014Innovative Technologies and Methods, Wiley.","DOI":"10.1002\/9783527699902.ch7"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Moonsamy, G., Zulu, N.N., Lalloo, R., Ramchuran, S., and Singh, S. (2020). Large-scale production of an abalone probiotic, Vibrio midae, isolated from a South African abalone, Halitotis midae for use in aquaculture. Biocatal. Agric. Biotechnol., 29.","DOI":"10.1016\/j.bcab.2020.101794"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Misra, S., and Raghuwanshi, S. (2022). Safety Concerns, Regulatory Guidelines, Current Market Trends, and Future Directions toward the Use of Probiotics in Gut-Brain-Skin Axis. Probiotic Research in Therapeutics, Springer.","DOI":"10.1007\/978-981-16-5628-6_10"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Hahn-H\u00e4gerdal, B., Karhumaa, K., Larsson, C.U., Gorwa-Grauslund, M., G\u00f6rgens, J., and van Zyl, W.H. (2005). Role of cultivation media in the development of yeast strains for large scale industrial use. Microb. Cell Factories, 4.","DOI":"10.1186\/1475-2859-4-31"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11055","DOI":"10.1080\/21655979.2021.2005992","article-title":"Functional foods as a formulation ingredients in beverages: Technological advancements and constraints","volume":"12","author":"Sharma","year":"2021","journal-title":"Bioengineered"},{"key":"ref_56","unstructured":"BBC Market Research (2023, October 31). Probiotics in Food, Beverages, Dietary Supplements and Animal Feed. Boston, August 2022. Available online: https:\/\/www.researchandmarkets.com\/reports\/4895936\/probiotics-in-food-beverages-dietary?srsltid=AfmBOoq6McteWvnGYxcktND41GYNMt_Q-boHfIuF8xK-tmHL0ZoPWlMj."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"O\u2019Toole, P.W., Marchesi, J.R., and Hill, C. (2017). Next-generation probiotics: The spectrum from probiotics to live biotherapeutics. Nat. Microbiol., 2.","DOI":"10.1038\/nmicrobiol.2017.57"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cgh.2018.01.018","article-title":"The Unregulated Probiotic Market","volume":"17","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3201\/eid1611.100574","article-title":"Regulatory Oversight and Safety of Probiotic Use","volume":"16","author":"Venugopalan","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_60","first-page":"1487","article-title":"New Concepts in Nutraceuticals as Alternative for Pharmaceuticals","volume":"5","author":"Nasri","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.3748\/wjg.v26.i43.6706","article-title":"Gastric acid level of humans must decrease in the future","volume":"26","author":"Fujimori","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1128\/AEM.00695-16","article-title":"Oral administration of probiotics inhibits absorption of the heavy metal cadmium by protecting the intestinal barrier","volume":"82","author":"Zhai","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Cazorla, S.I., Maldonado-Galdeano, C., Weill, R., De Paula, J., and Perdig\u00f3n, G.D.V. (2018). Oral Administration of Probiotics Increases Paneth Cells and Intestinal Antimicrobial Activity. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.00736"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.clnu.2017.02.015","article-title":"Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: A systematic review and meta-analysis","volume":"37","author":"Hendijani","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Cifuentes, S.G., Prado, M.B., Fornasini, M., Cohen, H., Balde\u00f3n, M.E., and C\u00e1rdenas, P.A. (2022). Saccharomyces boulardii CNCM I-745 supplementation modifies the fecal resistome during Helicobacter pylori eradication therapy. Helicobacter, 27.","DOI":"10.1111\/hel.12870"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/ijfs.13745","article-title":"Neutralisation of toxins by probiotics during the transit into the gut: Challenges and perspectives","volume":"53","author":"Corbo","year":"2018","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.lwt.2018.10.082","article-title":"Probiotic alcohol-free beer made with Saccharomyces cerevisiae var. boulardii","volume":"100","author":"Senkarcinova","year":"2019","journal-title":"LWT"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1208\/s12249-013-0027-1","article-title":"A Review of the Advancements in Probiotic Delivery: Conventional vs. Non-conventional Formulations for Intestinal Flora Supplementation","volume":"15","author":"Govender","year":"2014","journal-title":"AAPS PharmSciTech"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4103\/japtr.japtr_116_21","article-title":"Fermented Foods as Probiotics","volume":"12","author":"Soemarie","year":"2021","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_70","first-page":"943","article-title":"Application of Saccharomyces cerevisiae var. boulardii in food processing: A review","volume":"125","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1111\/j.1365-2621.2012.03127.x","article-title":"Antioxidant properties of different milk fermented with lactic acid bacteria and yeast","volume":"47","author":"Parrella","year":"2012","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.copbio.2007.01.010","article-title":"Yeasts in foods and beverages: Impact on product quality and safety","volume":"18","author":"Fleet","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0168-1605(01)00569-4","article-title":"The growth, properties and interactions of yeasts and bacteria associated with the maturation of Camembert and blue-veined cheeses","volume":"69","author":"Addis","year":"2001","journal-title":"Int. J. Food Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3109\/09637486.2012.687364","article-title":"Effect of incorporating prebiotics in coating materials for the microencapsulation of Sacharomyces boulardii","volume":"63","author":"Ortega","year":"2012","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1111\/jam.15467","article-title":"Probiotic properties of yeasts in traditional fermented foods and beverages","volume":"132","author":"Tamang","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1111\/jam.15065","article-title":"Probiotic properties of yeasts isolated from Brazilian fermented table olives","volume":"131","author":"Ferreira","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Merch\u00e1n, A.V., Benito, M.J., Galv\u00e1n, A.I., and de Herrera, S.R.-M.S. (2020). Identification and selection of yeast with functional properties for future application in soft paste cheese. LWT, 124.","DOI":"10.1016\/j.lwt.2020.109173"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s12602-019-9518-z","article-title":"Probiotic Potential, Antioxidant Activity, and Phytase Production of Indigenous Yeasts Isolated from Indigenous Fermented Foods","volume":"12","author":"Menezes","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12602-020-09661-8","article-title":"In Vitro Properties of Potential Probiotic Indigenous Yeasts Originating from Fermented Food and Beverages in Taiwan","volume":"13","author":"Hsiung","year":"2021","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Fu, W., Xue, W., Liu, C., Tian, Y., Zhang, K., and Zhu, Z. (2020). Screening of Lactic Acid Bacteria and Yeasts from Sourdough as Starter Cultures for Reduced Allergenicity Wheat Products. Foods, 9.","DOI":"10.3390\/foods9060751"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1631\/jzus.B0710640","article-title":"Phytate: Impact on environment and human nutrition. A challenge for molecular breeding","volume":"9","author":"Bohn","year":"2008","journal-title":"J. Zhejiang Univ. B"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"K\u00fc\u00e7\u00fckg\u00f6z, K., and Trz\u0105skowska, M. (2022). Nondairy Probiotic Products: Functional Foods That Require More Attention. Nutrients, 14.","DOI":"10.3390\/nu14040753"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"de Paula, B.P., Ch\u00e1vez, D.W.H., Junior, W.J.F.L., Guerra, A.F., Corr\u00eaa, M.F.D., Pereira, K.S., and Coelho, M.A.Z. (2019). Growth Parameters and Survivability of Saccharomyces boulardii for Probiotic Alcoholic Beverages Development. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02092"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tifs.2015.09.004","article-title":"Application of probiotic delivery systems in meat products","volume":"46","author":"Cavalheiro","year":"2015","journal-title":"Trends Food Sci. Technol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Han, S., Lu, Y., Xie, J., Fei, Y., Zheng, G., Wang, Z., Liu, J., Lv, L., Ling, Z., and Berglund, B. (2021). Probiotic Gastrointestinal Transit and Colonization After Oral Administration: A Long Journey. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.609722"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1080\/07373937.2022.2044844","article-title":"Role of drying technology in probiotic encapsulation and impact on food safety","volume":"40","author":"Sehrawat","year":"2022","journal-title":"Dry. Technol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Palanivelu, J., Thanigaivel, S., Vickram, S., Dey, N., Mihaylova, D., and Desseva, I. (2022). Probiotics in Functional Foods: Survival Assessment and Approaches for Improved Viability. Appl. Sci., 12.","DOI":"10.3390\/app12010455"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1111\/ijfs.14829","article-title":"Coated alginate\u2013chitosan particles to improve the stability of probiotic yeast","volume":"56","author":"Santos","year":"2021","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Rajam, R., and Subramanian, P. (2022). Encapsulation of probiotics: Past, present and future. Beni-Suef Univ. J. Basic Appl. Sci., 11.","DOI":"10.1186\/s43088-022-00228-w"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1080\/10408398.2020.1854169","article-title":"Co-encapsulation of probiotics with prebiotics and their application in functional\/synbiotic dairy products","volume":"62","author":"Rashidinejad","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12602-021-09791-7","article-title":"Targeted Delivery of Probiotics: Perspectives on Research and Commercialization","volume":"14","author":"Yoha","year":"2022","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejbt.2020.09.005","article-title":"Survival of commercial probiotic strains and their effect on dark chocolate synbiotic snack with raspberry content during the storage and after simulated digestion","volume":"48","author":"Szczepaniak","year":"2020","journal-title":"Electron. J. Biotechnol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Chan, M.Z.A., Toh, M., and Liu, S.-Q. (2021). Growth, survival, and metabolic activities of probiotics Lactobacillus rhamnosus GG and Saccharomyces cerevisiae var. boulardii CNCM-I745 in fermented coffee brews. Int. J. Food Microbiol., 350.","DOI":"10.1016\/j.ijfoodmicro.2021.109229"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1080\/10408398.2020.1761773","article-title":"A review of the microencapsulation techniques for the incorporation of probiotic bacteria in functional foods","volume":"61","author":"Frakolaki","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kvakova, M., Bertkova, I., Stofilova, J., and Savidge, T.C. (2021). Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation. Foods, 10.","DOI":"10.3390\/foods10061297"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ohlmaier-Delgadillo, F., Carvajal-Millan, E., L\u00f3pez-Franco, Y.L., Islas-Osuna, M.A., Micard, V., Antoine-Assor, C., and Rasc\u00f3n-Chu, A. (2021). Ferulated Pectins and Ferulated Arabinoxylans Mixed Gel for Saccharomyces boulardii Entrapment in Electrosprayed Microbeads. Molecules, 26.","DOI":"10.3390\/molecules26092478"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Chavarri, M., Maranon, I., and Carmen, M. (2012). Encapsulation Technology to Protect Probiotic Bacteria. Probiotics, InTech.","DOI":"10.5772\/50046"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Terpou, A., Papadaki, A., Lappa, I.K., Kachrimanidou, V., Bosnea, L.A., and Kopsahelis, N. (2019). Probiotics in Food Systems: Significance and Emerging Strategies Towards Improved Viability and Delivery of Enhanced Beneficial Value. Nutrients, 11.","DOI":"10.3390\/nu11071591"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tifs.2021.05.022","article-title":"Encapsulation of probiotics and nutraceuticals: Applications in functional food industry","volume":"114","author":"Reque","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Rodrigues, F., Cedran, M., Bicas, J., and Sato, H. (2020). Encapsulated probiotic cells: Relevant techniques, natural sources as encapsulating materials and food applications\u2014A narrative review. Food Res. Int., 137.","DOI":"10.1016\/j.foodres.2020.109682"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Pech-Canul, A.d.l.C., Ortega, D., Garc\u00eda-Triana, A., Gonz\u00e1lez-Silva, N., and Solis-Oviedo, R.L. (2020). A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics. Coatings, 10.","DOI":"10.3390\/coatings10030197"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"C\u0103linoiu, L.-F., \u015etef\u0103nescu, B.E., Pop, I.D., Muntean, L., and Vodnar, D.C. (2019). Chitosan Coating Applications in Probiotic Microencapsulation. Coatings, 9.","DOI":"10.3390\/coatings9030194"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Muhammad, Z., Ramzan, R., Zhang, R., and Zhang, M. (2021). Resistant Starch-Based Edible Coating Composites for Spray-Dried Microencapsulation of Lactobacillus acidophilus, Comparative Assessment of Thermal Protection, In Vitro Digestion and Physicochemical Characteristics. Coatings, 11.","DOI":"10.3390\/coatings11050587"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Dadkhodazade, E., Khanniri, E., Khorshidian, N., Hosseini, S.M., Mortazavian, A.M., and Kia, E.M. (2021). Yeast cells for encapsulation of bioactive compounds in food products: A review. Biotechnol. Prog., 37.","DOI":"10.1002\/btpr.3138"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1007\/s00253-013-5044-1","article-title":"Encapsulation in a natural, preformed, multi-component and complex capsule: Yeast cells","volume":"97","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Poddar, D., Palmer, J., Das, S., Gaare, M., Nag, A., and Singh, H. (2021). Effect of Fluidized Bed Drying, Matrix Constituents and Structure on the Viability of Probiotic Lactobacillus paracasei ATCC 55544 during Storage at 4 \u00b0C, 25 \u00b0C and 37 \u00b0C. Microorganisms, 10.","DOI":"10.3390\/microorganisms10010074"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1080\/10408398.2017.1377684","article-title":"Protective approaches and mechanisms of microencapsulation to the survival of probiotic bacteria during processing, storage and gastrointestinal digestion: A review","volume":"59","author":"Liu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Lim, D.-H., Letona, A., Lee, M., Lim, D., Han, N.-S., and Chung, D. (2021). Fluidized-Bed Granulation of Probiotics-Encapsulated Spray-Dried Skim Milk Powder: Effects of a Fluidizing Aid, Moisture-Activation and Dehydration. Foods, 10.","DOI":"10.3390\/foods10071600"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Dhakal, S.P., and He, J. (2020). Microencapsulation of vitamins in food applications to prevent losses in processing and storage: A review. Food Res. Int., 137.","DOI":"10.1016\/j.foodres.2020.109326"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s11947-022-02796-2","article-title":"A Review on Probiotic Microencapsulation and Recent Advances of their Application in Bakery Products","volume":"15","author":"Arepally","year":"2022","journal-title":"Food Bioprocess Technol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Chen, B., Liang, Z., Lin, X., Li, W., Lin, X., and He, Z. (2022). Enhanced survival of fluidized bed-dried microencapsulated Saccharomyces cerevisiae cells in the presence of Hongqu rice distiller\u2019s grain peptides. LWT, 163.","DOI":"10.1016\/j.lwt.2022.113511"},{"key":"ref_112","first-page":"347","article-title":"Fluidized Bed Drying of A Granulated Prototype Based on A Potential Probiotic Yeast Meyerozyma guilliermondii: Selection of Process Parameters and Drying Protectant","volume":"16","author":"Chaparro","year":"2017","journal-title":"Rev. Mex. Ing. Quim."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1080\/09168451.2020.1756213","article-title":"Enhanced lactic acid bacteria viability with yeast coincubation under acidic conditions","volume":"84","author":"Hirai","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Zahoor, F., Sooklim, C., Songdech, P., Duangpakdee, O., and Soontorngun, N. (2021). Selection of Potential Yeast Probiotics and a Cell Factory for Xylitol or Acid Production from Honeybee Samples. Metabolites, 11.","DOI":"10.3390\/metabo11050312"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-020-01490-2","article-title":"Whole genome sequencing and metabolomics analyses reveal the biosynthesis of nerol in a multi-stress-tolerant Meyerozyma guilliermondii GXDK6","volume":"20","author":"Mo","year":"2021","journal-title":"Microb. Cell Factories"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.lwt.2013.03.004","article-title":"The utilization of oat polar lipids produced by supercritical fluid technologies in the encapsulation of probiotics","volume":"53","author":"Aro","year":"2013","journal-title":"LWT"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11274-013-1465-3","article-title":"Supercritical CO2 interpolymer complex encapsulation improves heat stability of probiotic bifidobacteria","volume":"30","author":"Thantsha","year":"2014","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijpharm.2015.12.021","article-title":"Micronization, characterization and in-vitro dissolution of shellac from PGSS supercritical CO2 technique","volume":"499","author":"Labuschagne","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/07373937.2019.1581797","article-title":"Effect of skimmed milk powder concentrations on the biological characteristics of microencapsulated Saccharomyces cerevisiae by vacuum-spray-freeze-drying","volume":"38","author":"Cao","year":"2020","journal-title":"Dry. Technol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfoodeng.2014.03.015","article-title":"Enhanced viability of probiotic Saccharomyces boulardii encapsulated by layer-by-layer approach in pH responsive chitosan\u2013dextran sulfate polyelectrolytes","volume":"136","author":"Vaidyanathan","year":"2014","journal-title":"J. Food Eng."},{"key":"ref_121","unstructured":"Choi, Y. (2014). Analysis of Technology and Market trend analysis of Probiotics. The Korea Contents Association, Proceedings of the Korea Contents Association Conference, The Korea Contents Association."},{"key":"ref_122","first-page":"450","article-title":"Current Trends in Non-Dairy Probiotics and Their Acceptance among Consumers: A Review","volume":"43","author":"Natt","year":"2021","journal-title":"Agric. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Grover, S., Rashmi, H.M., Srivastava, A.K., and Batish, V.K. (2012). Probiotics for human health\u2014new innovations and emerging trends. Gut Pathog., 4.","DOI":"10.1186\/1757-4749-4-15"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41569-022-00771-0","article-title":"The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease","volume":"20","author":"Chakaroun","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"McCoubrey, L.E., Seegobin, N., Elbadawi, M., Hu, Y., Orlu, M., Gaisford, S., and Basit, A.W. (2022). Active Machine learning for formulation of precision probiotics. Int. J. Pharm., 616.","DOI":"10.1016\/j.ijpharm.2022.121568"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Berm\u00fadez-Humar\u00e1n, L.G., Salinas, E., Ortiz, G.G., Ram\u00edrez-Jirano, L.J., Morales, J.A., and Bitzer-Quintero, O.K. (2019). From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis. Nutrients, 11.","DOI":"10.3390\/nu11040890"},{"key":"ref_127","first-page":"688","article-title":"The Use of \u201cIntermediary Language\u201d in Teaching Turkish as A Foreign Language","volume":"7","year":"2022","journal-title":"Int. J. Educ. Technol. Sci. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4093\/dmj.2015.39.4.291","article-title":"Probiotics as Complementary Treatment for Metabolic Disorders","volume":"39","author":"Varin","year":"2015","journal-title":"Diabetes Metab. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.maturitas.2018.11.002","article-title":"Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?","volume":"119","author":"Dargahi","year":"2019","journal-title":"Maturitas"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/1751-7915.13685","article-title":"Defining how microorganisms benefit human health","volume":"14","author":"Marco","year":"2020","journal-title":"Microb. Biotechnol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Khan, R., Petersen, F.C., and Shekhar, S. (2019). Commensal bacteria: An emerging player in defense against respiratory pathogens. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01203"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1101\/gr.191320.115","article-title":"The intersection of microbiome and host at the skin interface: Genomic- and metagenomic-based insights","volume":"25","author":"Grice","year":"2015","journal-title":"Genome Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"De Pessemier, B., Grine, L., Debaere, M., Maes, A., Paetzold, B., and Callewaert, C. (2021). Gut\u2013Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms, 9.","DOI":"10.3390\/microorganisms9020353"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/bies.201600008","article-title":"The gut-skin axis in health and disease: A paradigm with therapeutic implications","volume":"38","author":"Monteleone","year":"2016","journal-title":"BioEssays"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0207096","article-title":"Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis","volume":"82","author":"Shaykhiev","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Cresci, G.A., and Izzo, K. (2019). Gut microbiome. Adult Short Bowel Syndrome: Nutritional, Medical, and Surgical Management, Academic Press.","DOI":"10.1016\/B978-0-12-814330-8.00004-4"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"Groen","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phrs.2012.10.007","article-title":"Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications","volume":"69","author":"Natividad","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrgastro.2010.117","article-title":"Probiotics and the gut microbiota in intestinal health and disease","volume":"7","author":"Gareau","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_141","first-page":"115","article-title":"Gut Microbiota and Metabolism","volume":"1","year":"2018","journal-title":"Int. J. Med. Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., and Tuohy, K. (2018). Gut microbiota functions: Metabolism of nutrients and other food components. Eur. J. Nutr., 57.","DOI":"10.1007\/s00394-017-1445-8"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cmi.2021.07.034","article-title":"The human gut mycobiome and the specific role of Candida albicans: Where do we stand, as clinicians?","volume":"28","author":"Musumeci","year":"2022","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Dollive, S., Peterfreund, G.L., Sherrill-Mix, S., Bittinger, K., Sinha, R., Hoffmann, C., Nabel, C.S., A Hill, D., Artis, D., and A Bachman, M. (2012). A tool kit for quantifying eukaryotic rRNA gene sequences from human microbiome samples. Genome Biol., 13.","DOI":"10.1186\/gb-2012-13-7-r60"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Nash, A.K., Auchtung, T.A., Wong, M.C., Smith, D.P., Gesell, J.R., Ross, M.C., Stewart, C.J., Metcalf, G.A., Muzny, D.M., and Gibbs, R.A. (2017). The gut mycobiome of the Human Microbiome Project healthy cohort. Microbiome, 5.","DOI":"10.1186\/s40168-017-0373-4"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Boxberger, M., Cenizo, V., Cassir, N., and La Scola, B. (2021). Challenges in exploring and manipulating the human skin microbiome. Microbiome, 9.","DOI":"10.1186\/s40168-021-01062-5"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature25177","article-title":"Skin microbiota\u2013host interactions","volume":"553","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Zhou, H., Shi, L., Ren, Y., Tan, X., Liu, W., and Liu, Z. (2020). Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.570261"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1126\/science.1254229","article-title":"The gentle touch receptors of mammalian skin","volume":"346","author":"Zimmerman","year":"2014","journal-title":"Science"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","article-title":"The human skin microbiome","volume":"16","author":"Byrd","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15698\/mic2020.06.718","article-title":"Fungal infections in humans: The silent crisis","volume":"7","author":"Kainz","year":"2020","journal-title":"Microb. Cell"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4236\/aim.2020.109037","article-title":"Probiotics Potential of Yeast and Lactic Acid Bacteria Fermented Foods and the Impact of Processing: A Review of Indigenous and Continental Food Products","volume":"10","author":"Kwofie","year":"2020","journal-title":"Adv. Microbiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00284-020-02053-9","article-title":"Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases","volume":"77","author":"Ruszkowski","year":"2020","journal-title":"Curr. Microbiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrgastro.2014.188","article-title":"Mycobiota in gastrointestinal diseases","volume":"12","author":"Mukherjee","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Abid, R., Waseem, H., Ali, J., Ghazanfar, S., Ali, G.M., Elasbali, A.M., and Alharethi, S.H. (2022). Probiotic Yeast Saccharomyces: Back to Nature to Improve Human Health. J. Fungi, 8.","DOI":"10.3390\/jof8050444"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.anaerobe.2008.04.003","article-title":"Molecular analysis of the digestive microbiota in a gnotobiotic mouse model during antibiotic treatment: Influence of Saccharomyces boulardii","volume":"14","author":"Barc","year":"2008","journal-title":"Anaerobe"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/S0399-8320(10)70024-5","article-title":"Saccharomyces boulardii modulates dendritic cell properties and intestinal microbiota disruption after antibiotic treatment","volume":"34","author":"Collignon","year":"2010","journal-title":"Gastroenterol. Clin. Biol."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Mor\u00e9, M.I., and Swidsinski, A. (2015). Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis\u2014A review. Clin. Exp. Gastroenterol., 8.","DOI":"10.2147\/CEG.S85574"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Wu, X., Xia, Y., He, F., Zhu, C., and Ren, W. (2021). Intestinal mycobiota in health and diseases: From a disrupted equilibrium to clinical opportunities. Microbiome, 9.","DOI":"10.1186\/s40168-021-01024-x"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/11\/2233\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:26:16Z","timestamp":1760113576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/12\/11\/2233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":159,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["microorganisms12112233"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms12112233","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]}}}