{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:47:53Z","timestamp":1792212473195,"version":"4.4.0"},"reference-count":97,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["SIP 20220742"],"award-info":[{"award-number":["SIP 20220742"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["20220795"],"award-info":[{"award-number":["20220795"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["20231480"],"award-info":[{"award-number":["20231480"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["20231481"],"award-info":[{"award-number":["20231481"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["20240945"],"award-info":[{"award-number":["20240945"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["20240946"],"award-info":[{"award-number":["20240946"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado-IPN","award":["CB 283225"],"award-info":[{"award-number":["CB 283225"]}]},{"name":"CONACYT","award":["SIP 20220742"],"award-info":[{"award-number":["SIP 20220742"]}]},{"name":"CONACYT","award":["20220795"],"award-info":[{"award-number":["20220795"]}]},{"name":"CONACYT","award":["20231480"],"award-info":[{"award-number":["20231480"]}]},{"name":"CONACYT","award":["20231481"],"award-info":[{"award-number":["20231481"]}]},{"name":"CONACYT","award":["20240945"],"award-info":[{"award-number":["20240945"]}]},{"name":"CONACYT","award":["20240946"],"award-info":[{"award-number":["20240946"]}]},{"name":"CONACYT","award":["CB 283225"],"award-info":[{"award-number":["CB 283225"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Streptomyces is a genus of Gram-positive bacteria with high GC content. It remains attractive for studying and discovering new antibiotics, antifungals, and chemotherapeutics. Streptomyces genomes can contain more than 30 cryptic and expressed biosynthetic gene clusters (BGC) encoding secondary metabolites. In this study, three Streptomyces strains isolated from jungle rhizospheric soil exhibited supernatants that can inhibit sensitive and fluconazole-resistant Candida spp. The genomes of the strains Streptomyces sp. A1, J25, J29 ori2 were sequenced, assembled de novo, and analyzed. The genome assemblies revealed that the size of the genomes was 6.9 Mb, with linear topology and 73.5% GC. A phylogenomic approach identified the strains with high similitudes between 98.5 and 98.7% with Streptomyces albidoflavus SM254 and R-53649 strains, respectively. Pangenomic analysis of eight genomes of S. albidoflavus strains deposited in the Genomes database recognized 4707 core protein orthogroups and 745 abundant accessory and exclusive protein orthogroups, suggesting an open pangenome in this species. The antiSMASH software detected candicidin and surugamide BGC-encoding polyene and octapeptide antifungal secondary metabolites in other S. albidoflavus. CORASON software was used to compare the synteny, and the abundance of genes harbored in the clusters was used. In conclusion, although the three strains belong to the same species, each possesses a distinct genome, as evidenced by the different phenotypes, including antifungal and extracellular enzymatic activities.<\/jats:p>","DOI":"10.3390\/microorganisms12122637","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:50:44Z","timestamp":1734591044000},"page":"2637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparative Genomics and Biosynthetic Cluster Analysis of Antifungal Secondary Metabolites of Three Strains of Streptomyces albidoflavus Isolated from Rhizospheric Soils"],"prefix":"10.3390","volume":"12","author":[{"given":"Adilene","family":"Gonzalez-Silva","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. Carpio y Plan de Ayala S\/N, Mexico City CP 11430, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"San Juan-Mendo","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. Carpio y Plan de Ayala S\/N, Mexico City CP 11430, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-9269","authenticated-orcid":false,"given":"Gustavo","family":"Delgado-Prudencio","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca CP 62210, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Alfredo","family":"Hern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. Carpio y Plan de Ayala S\/N, Mexico City CP 11430, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Larios-Serrato","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. Carpio y Plan de Ayala S\/N, Mexico City CP 11430, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 575 Stadium Mall Dr. West Lafayette, Indiana, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-2991","authenticated-orcid":false,"given":"Lourdes","family":"Villa-Tanaca","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. Carpio y Plan de Ayala S\/N, Mexico City CP 11430, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-9789","authenticated-orcid":false,"given":"C\u00e9sar","family":"Hern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. Carpio y Plan de Ayala S\/N, Mexico City CP 11430, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Youseif, S.H., Abd El-Megeed, F.H., Humm, E.A., Maymon, M., Mohamed, A.H., Saleh, S.A., and Hirsch, A.M. (2021). Comparative Analysis of the Cultured and Total Bacterial Community in the Wheat Rhizosphere Microbiome Using Culture-Dependent and Culture-Independent Approaches. Microbiol. 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