{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:40:33Z","timestamp":1788025233137,"version":"build-2784847793"},"reference-count":127,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Robert J. Sirny Memorial Endowed Professorship Fund (YC), Oklahoma Center for Respiratory and Infectious Diseases","award":["P30GM149368"],"award-info":[{"award-number":["P30GM149368"]}]},{"name":"Robert J. Sirny Memorial Endowed Professorship Fund (YC), Oklahoma Center for Respiratory and Infectious Diseases","award":["R21AI166118"],"award-info":[{"award-number":["R21AI166118"]}]},{"name":"Robert J. Sirny Memorial Endowed Professorship Fund (YC), Oklahoma Center for Respiratory and Infectious Diseases","award":["R01AI173180"],"award-info":[{"award-number":["R01AI173180"]}]},{"name":"Robert J. Sirny Memorial Endowed Professorship Fund (YC), Oklahoma Center for Respiratory and Infectious Diseases","award":["HR21-050"],"award-info":[{"award-number":["HR21-050"]}]},{"name":"National Institutes of Health","award":["P30GM149368"],"award-info":[{"award-number":["P30GM149368"]}]},{"name":"National Institutes of Health","award":["R21AI166118"],"award-info":[{"award-number":["R21AI166118"]}]},{"name":"National Institutes of Health","award":["R01AI173180"],"award-info":[{"award-number":["R01AI173180"]}]},{"name":"National Institutes of Health","award":["HR21-050"],"award-info":[{"award-number":["HR21-050"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["P30GM149368"],"award-info":[{"award-number":["P30GM149368"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["R21AI166118"],"award-info":[{"award-number":["R21AI166118"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["R01AI173180"],"award-info":[{"award-number":["R01AI173180"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["HR21-050"],"award-info":[{"award-number":["HR21-050"]}]},{"name":"Oklahoma Center for the Advancement of Science &amp; Technology","award":["P30GM149368"],"award-info":[{"award-number":["P30GM149368"]}]},{"name":"Oklahoma Center for the Advancement of Science &amp; Technology","award":["R21AI166118"],"award-info":[{"award-number":["R21AI166118"]}]},{"name":"Oklahoma Center for the Advancement of Science &amp; Technology","award":["R01AI173180"],"award-info":[{"award-number":["R01AI173180"]}]},{"name":"Oklahoma Center for the Advancement of Science &amp; Technology","award":["HR21-050"],"award-info":[{"award-number":["HR21-050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Mycobacterial infections, caused by various species within the Mycobacterium genus, remain one of the main challenges to global health across the world. Understanding the complex interplay between the host and mycobacterial pathogens is essential for developing effective diagnostic and therapeutic strategies. Host long noncoding RNAs (lncRNAs) have emerged as key regulators in cellular response to bacterial infections within host cells. This review provides an overview of the intricate relationship between mycobacterial infections and host lncRNAs in the context of Mycobacterium tuberculosis and non-tuberculous mycobacterium (NTM) infections. Accumulation of evidence indicates that host lncRNAs play a critical role in regulating cellular response to mycobacterial infection within host cells, such as macrophages, the primary host cells for mycobacterial intracellular survival. The expression of specific host lncRNAs has been implicated in the pathogenesis of mycobacterial infections, providing potential targets for the development of novel host-directed therapies and biomarkers for TB diagnosis. In summary, this review aims to highlight the current state of knowledge regarding the involvement of host lncRNAs in mycobacterial infections. It also emphasizes their potential application as novel diagnostic biomarkers and therapeutic targets.<\/jats:p>","DOI":"10.3390\/microorganisms12122656","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:58:27Z","timestamp":1734933507000},"page":"2656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Host Long Noncoding RNAs as Key Players in Mycobacteria\u2013Host Interactions"],"prefix":"10.3390","volume":"12","author":[{"given":"Stephen K.","family":"Kotey","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA"},{"name":"Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejuan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA"},{"name":"Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey L.","family":"Kinser","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA"},{"name":"Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4811-4897","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK 74078, USA"},{"name":"Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA"},{"name":"Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e01289-15","DOI":"10.1128\/mBio.01289-15","article-title":"Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development","volume":"6","author":"Broset","year":"2015","journal-title":"mBio"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/ciaa1125","article-title":"Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS\/ERS\/ESCMID\/IDSA Clinical Practice Guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin. 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