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Understanding the intracellular transport and genome repair mechanisms of HBV is crucial for developing new drugs, which\u2014in combination with immune modulators\u2014may contribute to potential cures. This review will explore the current knowledge of HBV intracytoplasmic and nuclear transport, as well as genome repair processes, while drawing comparisons to other viruses with nuclear replication.<\/jats:p>","DOI":"10.3390\/microorganisms13010157","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:13:07Z","timestamp":1736835187000},"page":"157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From the Cytoplasm into the Nucleus\u2014Hepatitis B Virus Travel and Genome Repair"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8483-6504","authenticated-orcid":false,"given":"Johan","family":"Ringlander","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden"},{"name":"Department of Clinical Microbiology, Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital, 41346 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-2251","authenticated-orcid":false,"given":"Gustaf E.","family":"Rydell","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kann","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden"},{"name":"Department of Clinical Microbiology, Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital, 41346 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a021352","DOI":"10.1101\/cshperspect.a021352","article-title":"Animal models and the molecular biology of hepadnavirus infection","volume":"5","author":"Mason","year":"2015","journal-title":"Cold Spring Harb. 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