{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:39:47Z","timestamp":1759970387344,"version":"build-2065373602"},"reference-count":83,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"],"award-info":[{"award-number":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"],"award-info":[{"award-number":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Talent Special Fund of the First Affiliated Hospital of Nanjing Medical University","award":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"],"award-info":[{"award-number":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"]}]},{"name":"China Postdoctoral Science Foundation","award":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"],"award-info":[{"award-number":["82102831","82403422","BK20241127","YNRCQN0302","2024M761480"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Radiation-induced skin toxicity, resulting from ionizing or nonionizing radiation, is a common skin disorder. However, the underlying relationship between skin microbiota and radiation-induced skin toxicity remains largely unexplored. Herein, we uncover the microbiota\u2013skin interaction based on a genome-wide association study (GWAS) featuring 150 skin microbiota and three types of skin microenvironment. Summary datasets of human skin microbiota were extracted from the GWAS catalog database, and summary datasets of radiation-induced skin toxicity from the FinnGen biobank. Mendelian Randomization (MR) analysis was leveraged to sort out the causal link between skin microbiota and radiation-induced skin toxicity. We identified 33 causal connections between human skin microbiota and radiation-induced skin toxicity, including 19 positive and 14 negative causative directions. Among these potential associations, the genus Staphylococcus could serve as a common risk factor for radiation-induced skin toxicity, especially for radiodermatitis. And Streptococcus salivarius was identified as a potential protective factor against radiation-induced skin toxicity. Additional analysis indicated no pleiotropy, heterogeneity, or reverse causal relationship in the results. We comprehensively assessed potential associations of skin microbiota with radiation-induced skin toxicity and identified several suggestive links. Our results provide promising targets for the prevention and treatment of radiation-induced skin toxicity.<\/jats:p>","DOI":"10.3390\/microorganisms13010194","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T10:27:58Z","timestamp":1737109678000},"page":"194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bidirectional Mendelian Randomization Analysis to Study the Relationship Between Human Skin Microbiota and Radiation-Induced Skin Toxicity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-7626","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kexin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Kenneth P. Dietrich School of Arts & Science, University of Pittsburgh, Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-2077","authenticated-orcid":false,"given":"Zhipeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1080\/19490976.2020.1745044","article-title":"Skin Exposure to Sunlight: A Factor Modulating the Human Gut Microbiome Composition","volume":"11","author":"Conteville","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0118744710285874240326041025","article-title":"Response of Male Reproductive System against Ionizing Radiation and Available Radio-Protective Agents: Cellular and Molecular Insight","volume":"18","author":"Parashar","year":"2024","journal-title":"CRP"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tuieng, R.J., Cartmell, S.H., Kirwan, C.C., and Sherratt, M.J. 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