{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:25:53Z","timestamp":1791656753773,"version":"4.3.4"},"reference-count":26,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Vector-borne infections (Arbovirosis) represent a significant threat to public health worldwide. Climate change, currently a global problem, seems to contribute to the incidence and prevalence of autochthonous and imported cases of arbovirosis in Europe. The aim of this work is to evaluate the impact of climate change on the occurrence and spread of arbovirosis in order to offer concrete ideas to the competent authorities and modulate surveillance plans on the basis of risk assessment. The results of official controls carried out from 2018 to 2023 on animals subjected to the Surveillance Plans for Blue Tongue, West Nile and Usutu viruses in the Campania Region were analyzed. Statistical analyses were performed using R software (version 4.5.0). The possible correlation between the prevalence of infections and climate parameters was evaluated with the \u201ccross-correlation time series\u201d (p-value &lt; 0.05). The generalized linear mixed model showed that for each unit increase in humidity and temperature, the probability of disease spread increased by 4.56% and 7.84%, respectively. The univariate logistic regression model and the odds ratio were necessary to evaluate the possible risk related to the proximity to wetlands or to bodies of water: in the past few years, these have represented a risk for the persistence and spread of arbovirosis in the Campania region.<\/jats:p>","DOI":"10.3390\/microorganisms13020449","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T06:41:12Z","timestamp":1739860872000},"page":"449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Temporal Analysis of Climate Change Impact on the Spread and Prevalence of Vector-Borne Diseases in Campania (2018\u20132023)"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6064-8764","authenticated-orcid":false,"given":"Federica","family":"Gargano","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Regional Observatory (OREB), Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1597-9322","authenticated-orcid":false,"given":"Roberta","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Regional Observatory (OREB), Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Buonanno","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Regional Observatory (OREB), Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0948-5513","authenticated-orcid":false,"given":"Claudio","family":"De Martinis","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3050-1095","authenticated-orcid":false,"given":"Lorena","family":"Cardillo","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellegrino","family":"Fenizia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Regional Observatory (OREB), Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9839-5705","authenticated-orcid":false,"given":"Antonietta","family":"Anatriello","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"},{"name":"Regional Center of Pharmacovigilance and Pharmacoepidemiology of Campania Region, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5848-2060","authenticated-orcid":false,"given":"Giuseppe","family":"Rofrano","sequence":"additional","affiliation":[{"name":"National Reference Center for the Analysis and Study of Correlation between Environment, Animal and Man, Istituto Zooprofilattico Sperimentale del Mezzogiorno, IZS Mezzogiorno, Via Salute 2, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-5735","authenticated-orcid":false,"given":"Luigi Jacopo","family":"D\u2019Auria","sequence":"additional","affiliation":[{"name":"National Reference Center for the Analysis and Study of Correlation between Environment, Animal and Man, Istituto Zooprofilattico Sperimentale del Mezzogiorno, IZS Mezzogiorno, Via Salute 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Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs387\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ryan, S.J., Carlson, C.J., Mordecai, E.A., and Johnson, L.R. (2019). Global expansion and redistribution of Aedes-borne virus transmission risk with climate change. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007213"},{"key":"ref_3","unstructured":"Estrada-Pe\u00f1a, A., Ortega, C.N., Peterson, A.T., and Tsuji, N. (2020). Climate change and the transmission potential of vector-borne diseases: An overview. Front. Public Health, 8."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature04188","article-title":"Impact of regional climate change on human health","volume":"438","author":"Patz","year":"2005","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4081\/gh.2014.29","article-title":"Climate change and the potential global distribution of Aedes aegypti: Spatial modelling using geographical information system and CLIMEX","volume":"8","author":"Khormi","year":"2014","journal-title":"Geospat. Health"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Semenza, J.C., and Suk, J.E. (2018). Vector-borne diseases and climate change: A European perspective. FEMS Microbiol. Lett., 365.","DOI":"10.1093\/femsle\/fnx244"},{"key":"ref_7","first-page":"2282","article-title":"Air travel and the global spread of infectious diseases: A simulation study","volume":"367","author":"Tatem","year":"2006","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ippoliti, C., Candeloro, L., Gilbert, M., Goffredo, M., Mancini, G., Curci, G., Falasca, S., Tora, S., Di Lorenzo, A., and Quaglia, M. (2019). Defining ecological regions in Italy based on a multivariate clustering approach: A first step towards a targeted vector borne disease surveillance. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0219072"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.20506\/rst.34.1.2349","article-title":"Mosquitoes and Culicoides biting midges: Vector range and the influence of climate change","volume":"34","author":"Elbers","year":"2015","journal-title":"Rev. Sci. Tech. Off. Int. Epiz."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Musto, C., Tamba, M., Calzolari, M., Rossi, A., Grisendi, A., Marzani, K., Bonilauri, P., and Delogu, M. (2023). Detection of West Nile and Usutu virus RNA in autumn season in wild avian hosts in Northern Italy. Viruses, 15.","DOI":"10.3390\/v15081771"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s11259-023-10215-w","article-title":"Bluetongue virus seroprevalence and risk factor analysis in cattle and water buffalo in southern Italy (Campania region)","volume":"48","author":"Ferrara","year":"2023","journal-title":"Vet. Res. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Alkhamis, M.A., Aguilar-Vega, C., Fountain-Jones, N.M., Lin, K., P\u00e9rez, A.M., and S\u00e1nchez-Vizca\u00edno, J.M. (2020). Global emergence and evolutionary dynamics of bluetongue virus. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-78673-9"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Paz, S. (2015). Climate change: Impacts on West Nile virus transmission in a global context. Philos. Trans. R. Soc. B Biol. Sci., 370.","DOI":"10.1098\/rstb.2013.0561"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Socha, W., Kwasnik, M., Larska, M., Rola, J., and Rozek, W. (2022). Vector-borne viral diseases as a current threat for human and animal health\u2014One health perspective. J. Clin. Med., 11.","DOI":"10.3390\/jcm11113026"},{"key":"ref_15","unstructured":"Box, G.E.P., Jenkins, G.M., Reinsel, G.C., and Ljung, G.M. (2015). Time Series Analysis: Forecasting and Control, Wiley. [5th ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Shumway, R.H., and Stoffer, D.S. (2017). Time Series Analysis and Its Applications: With R Examples, Springer.","DOI":"10.1007\/978-3-319-52452-8"},{"key":"ref_17","unstructured":"(2024, May 10). Available online: https:\/\/otexts.com\/fppit\/acf.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.limno.2013.11.002","article-title":"Flight distance of mosquitoes (Culicidae): A metadata analysis to support the management of barrier zones around rewetted and newly constructed wetlands","volume":"45","author":"Verdonschot","year":"2014","journal-title":"Limnologica"},{"key":"ref_19","unstructured":"Col\u00f3n-Gonz\u00e1lez, F.J., Harris, I., Osborn, T.J., and Jones, A.E. (2021). Climate variability and the transmission of vector-borne diseases: A review. Philos. Trans. R. Soc. B Biol. Sci., 376."},{"key":"ref_20","first-page":"509","article-title":"Detecting the impact of climate change on infectious diseases: Climate warming increases the transmission of vector-borne diseases","volume":"50","author":"Mordecai","year":"2019","journal-title":"Annu. Rev. Ecol. Evol. Syst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40249-024-01207-2","article-title":"Impact of climate change on the global circulation of West Nile virus and adaptation responses: A scoping review","volume":"13","author":"Wang","year":"2024","journal-title":"Infect. Dis. Poverty"},{"key":"ref_22","first-page":"79","article-title":"West Nile virus and climate change","volume":"114","author":"Fay","year":"2022","journal-title":"Adv. Virus Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jcv.2018.08.007","article-title":"Ongoing and emerging arbovirus threats in Europe","volume":"107","author":"Barzon","year":"2018","journal-title":"J. Clin. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/nyas.13950","article-title":"Impact of recent and future climate change on vector\u2013borne diseases","volume":"1436","author":"Caminade","year":"2019","journal-title":"Ann. New York Acad. Sci."},{"key":"ref_25","unstructured":"(2024, April 03). Available online: https:\/\/www.salute.gov.it\/imgs\/C_17_pubblicazioni_2947_allegato.pdf."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/S1473-3099(16)30518-7","article-title":"Epidemic arboviral diseases","volume":"17","author":"Gubler","year":"2017","journal-title":"Lancet Infect. 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