{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T02:48:11Z","timestamp":1786762091327,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Livestock Mission","award":["R-300121112022-DADF"],"award-info":[{"award-number":["R-300121112022-DADF"]}]},{"name":"National Livestock Mission","award":["ANSCNIVEDISIL202100900123"],"award-info":[{"award-number":["ANSCNIVEDISIL202100900123"]}]},{"name":"ICAR-NIVEDI","award":["R-300121112022-DADF"],"award-info":[{"award-number":["R-300121112022-DADF"]}]},{"name":"ICAR-NIVEDI","award":["ANSCNIVEDISIL202100900123"],"award-info":[{"award-number":["ANSCNIVEDISIL202100900123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Lumpy skin disease (LSD) is a re-emerging viral transboundary disease affecting cattle and buffaloes, resulting in a significant socio-economic impact on the affected regions. LSD is primarily transmitted among susceptible livestock through hematophagous vectors, including ticks and flies. Ticks also function as reservoirs for various haemoprotozoan parasites, increasing the likelihood of coinfections in affected animals. This study investigates the comorbidity of LSD and associated risk factors using diverse datasets. A total of 414 samples from LSD-suspected animals were screened for LSD, infectious bovine rhinotracheitis (IBR), malignant catarrhal fever (MCF), babesiosis, and theileriosis (Theileria annulata and Theileria orientalis), as well as anaplasmosis. Among these, 214 (51.6%) tested positive for LSD. A strong correlation was identified between LSD and oriental theileriosis caused by Theileria orientalis (50.9%). Other significant associations were observed with IBR (34.1%), anaplasmosis (24.7%), tropical theileriosis (15.4%), babesiosis (12.6%), and MCF (12.1%). The transmission dynamics of LSD revealed that hematophagous vectors, particularly Stomoxys, Haematobia, and Rhipicephalus, play a crucial role in its spread, especially in unorganised farming systems. Additionally, Haematobia and Stomoxys flies were implicated in the high transmission rate of oriental theileriosis (39%) in conjunction with LSD. Notably, ticks (Rhipicephalus) facilitated the concurrent transmission of one, two, or three infections alongside LSD. While Musca, a non-hematophagous fly, was found to carry LSD virus (LSDV), it did not test positive for other pathogens. This study highlights the potential for cattle to harbour multiple diseases simultaneously with LSD, emphasising the necessity for integrated transmission studies and comprehensive disease screening in affected livestock. These findings underscore the importance of implementing targeted prevention and control strategies to mitigate disease impact in livestock populations.<\/jats:p>","DOI":"10.3390\/microorganisms13030472","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T06:10:21Z","timestamp":1740031821000},"page":"472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Investigation of Comorbidity and Risk Factors Analysis During Lumpy Skin Disease Outbreaks in India"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-7823","authenticated-orcid":false,"given":"Gundallahalli Bayyappa","family":"Manjunatha Reddy","sequence":"first","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-0940","authenticated-orcid":false,"given":"Shraddha","family":"Bijalwan","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siju Susan","family":"Jacob","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Tadakod","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2856-3300","authenticated-orcid":false,"given":"Snigdha Madhaba","family":"Maharana","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-6710","authenticated-orcid":false,"given":"Sudeep","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4359-0401","authenticated-orcid":false,"given":"Sai Mounica","family":"Pabbineedi","sequence":"additional","affiliation":[{"name":"Veterinary Pathobiology, Oklahoma Center for Respiratory and Infectious Diseases (OCRID), Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6942-2924","authenticated-orcid":false,"given":"Chandana Ramesh","family":"Uma","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viveka Prabhu","family":"Balappa","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethan Kumar","family":"Harlipura Basavarajappa","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinaki Prasad","family":"Sengupta","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-7513","authenticated-orcid":false,"given":"Sharanagouda Shiddanagouda","family":"Patil","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4338-7941","authenticated-orcid":false,"given":"Baldev Raj","family":"Gulati","sequence":"additional","affiliation":[{"name":"ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), P.O. Box 6450, Yelahanka, Bengaluru 560119, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gongal, G., Rahman, H., Thakuri, K.C., and Vijayalakshmy, K. (2022). An overview of transboundary animal diseases of viral origin in South Asia: What needs to be done?. Vet. Sci., 9.","DOI":"10.3390\/vetsci9110586"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00705-024-05996-7","article-title":"First evidence of lumpy skin disease in mithun (Bos frontalis) in India","volume":"169","author":"Reddy","year":"2024","journal-title":"Arch. Virol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Manjunatha Reddy, G.B., Pabbineedi, S.M., Nagaraj, S., Bijalwan, S., Tadakod, S., Bhutia, Z., Palmu, D., Rai, S., Bhutia, P.D., and Bhutia, P.T. (2023). 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